Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100121210> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3100121210 startingPage "548511" @default.
- W3100121210 abstract "Summary The establishment of separated pulmonary and systemic circulations in vertebrates, via the cardiac outflow tract (OFT) septation, stands as a sensitive developmental process accounting for 10% of all congenital anomalies. It relies on the Neural Crest Cells (NCC) colonization of the heart, whose condensation along the endocardial wall forces its scission into two tubes. Here, we show that NCC aggregation starts more pronounced at distal OFT areas than at proximal sites. This spatial organisation correlates with a decreasing distal-proximal gradient of BMP signalling. Dullard, a nuclear phosphatase, sets the BMP gradient amplitude and prevents NCC premature condensation. Dullard is required for maintaining transcriptional programmes providing NCC with mesenchymal traits. It attenuates the adhesive cue Sema3c levels and conversely promotes the epithelial-mesenchymal transition driver Twist1 expression. Altogether, Dullard mediated fine-tuning of BMP signalling ensures the timed and progressive condensation of NCC and rules a zipper-like closure of the OFT." @default.
- W3100121210 created "2020-11-23" @default.
- W3100121210 creator A5021884279 @default.
- W3100121210 creator A5024146511 @default.
- W3100121210 creator A5027541838 @default.
- W3100121210 creator A5034323474 @default.
- W3100121210 creator A5041097015 @default.
- W3100121210 creator A5074144867 @default.
- W3100121210 creator A5086529456 @default.
- W3100121210 creator A5088823199 @default.
- W3100121210 creator A5089542187 @default.
- W3100121210 date "2019-08-08" @default.
- W3100121210 modified "2023-10-01" @default.
- W3100121210 title "Transcriptional control of cardiac neural crest cells condensation and outflow tract septation by the Smad1/5/8 inhibitor Dullard" @default.
- W3100121210 cites W1598019255 @default.
- W3100121210 hasPublicationYear "2019" @default.
- W3100121210 type Work @default.
- W3100121210 sameAs 3100121210 @default.
- W3100121210 citedByCount "0" @default.
- W3100121210 crossrefType "posted-content" @default.
- W3100121210 hasAuthorship W3100121210A5021884279 @default.
- W3100121210 hasAuthorship W3100121210A5024146511 @default.
- W3100121210 hasAuthorship W3100121210A5027541838 @default.
- W3100121210 hasAuthorship W3100121210A5034323474 @default.
- W3100121210 hasAuthorship W3100121210A5041097015 @default.
- W3100121210 hasAuthorship W3100121210A5074144867 @default.
- W3100121210 hasAuthorship W3100121210A5086529456 @default.
- W3100121210 hasAuthorship W3100121210A5088823199 @default.
- W3100121210 hasAuthorship W3100121210A5089542187 @default.
- W3100121210 hasConcept C105702510 @default.
- W3100121210 hasConcept C126322002 @default.
- W3100121210 hasConcept C126749454 @default.
- W3100121210 hasConcept C185592680 @default.
- W3100121210 hasConcept C196843134 @default.
- W3100121210 hasConcept C198826908 @default.
- W3100121210 hasConcept C71924100 @default.
- W3100121210 hasConcept C86803240 @default.
- W3100121210 hasConcept C95444343 @default.
- W3100121210 hasConceptScore W3100121210C105702510 @default.
- W3100121210 hasConceptScore W3100121210C126322002 @default.
- W3100121210 hasConceptScore W3100121210C126749454 @default.
- W3100121210 hasConceptScore W3100121210C185592680 @default.
- W3100121210 hasConceptScore W3100121210C196843134 @default.
- W3100121210 hasConceptScore W3100121210C198826908 @default.
- W3100121210 hasConceptScore W3100121210C71924100 @default.
- W3100121210 hasConceptScore W3100121210C86803240 @default.
- W3100121210 hasConceptScore W3100121210C95444343 @default.
- W3100121210 hasOpenAccess W3100121210 @default.
- W3100121210 hasRelatedWork W1121334130 @default.
- W3100121210 hasRelatedWork W1906437714 @default.
- W3100121210 hasRelatedWork W1976009723 @default.
- W3100121210 hasRelatedWork W2012040988 @default.
- W3100121210 hasRelatedWork W2072486463 @default.
- W3100121210 hasRelatedWork W2083399350 @default.
- W3100121210 hasRelatedWork W2101541364 @default.
- W3100121210 hasRelatedWork W2111761019 @default.
- W3100121210 hasRelatedWork W2164637607 @default.
- W3100121210 hasRelatedWork W2188518125 @default.
- W3100121210 hasRelatedWork W2276924976 @default.
- W3100121210 hasRelatedWork W2346623631 @default.
- W3100121210 hasRelatedWork W2737180196 @default.
- W3100121210 hasRelatedWork W2783745606 @default.
- W3100121210 hasRelatedWork W2886736764 @default.
- W3100121210 hasRelatedWork W2903596361 @default.
- W3100121210 hasRelatedWork W2947424782 @default.
- W3100121210 hasRelatedWork W2963158864 @default.
- W3100121210 hasRelatedWork W3113795691 @default.
- W3100121210 hasRelatedWork W3175906981 @default.
- W3100121210 isParatext "false" @default.
- W3100121210 isRetracted "false" @default.
- W3100121210 magId "3100121210" @default.
- W3100121210 workType "article" @default.