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- W3100122905 abstract "Abstract Purpose NODDI is widely used in parameterizing microstructural brain properties. The model includes three signal compartments: intracellular, extracellular, and free water. The neurite compartment intrinsic parallel diffusivity ( d ‖ ) is set to 1.7 µ m 2 ⋅ms −1 , though the effects of this assumption have not been extensively explored. This work seeks to optimize d ‖ by minimizing the model residuals. Methods The model residuals were evaluated in function of d ‖ over the range from 0.5 to 3.0 µ m 2 ⋅ms −1 . This was done with respect to tissue type (i.e., white matter versus gray matter), sex, age (infancy to late adulthood), and diffusion-weighting protocol (maximum b-value). Variation in the estimated parameters with respect to d ‖ was also explored. Results Results show the optimum d ‖ is significantly lower for gray matter relative to 1.7 µ m 2 ⋅ms −1 and to white matter. Infants showed significantly decreased optimum d ‖ in gray and white matter. Minor optimum d ‖ differences were observed versus diffusion protocol. No significant sex effects were observed. Additionally, changes in d ‖ resulted in significant changes to the estimated NODDI parameters. Conclusion Future implementations of NODDI would benefit from d ‖ optimization, particularly when investigating young populations and/or gray matter." @default.
- W3100122905 created "2020-11-23" @default.
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- W3100122905 date "2019-05-08" @default.
- W3100122905 modified "2023-10-16" @default.
- W3100122905 title "Optimizing the fitting initial condition for the parallel intrinsic diffusivity in NODDI: An extensive empirical evaluation" @default.
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- W3100122905 doi "https://doi.org/10.1101/630541" @default.
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