Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100130106> ?p ?o ?g. }
- W3100130106 endingPage "1306" @default.
- W3100130106 startingPage "1306" @default.
- W3100130106 abstract "We investigated temporal trends of codon usage changes for different host species to determine their importance in Zika virus (ZIKV) evolution. Viral spillover resulting from the potential of codon adaptation to host genome was also assessed for the African genotype ZIKV in comparison to the Asian genotype. To improve our understanding on its zoonotic maintenance, we evaluated in vitro the biological properties of the African genotype ZIKV in vertebrate and mosquito cell lines. Analyses were performed in comparison to Yellow fever virus (YFV). Despite significantly lower codon adaptation index trends than YFV, ZIKV showed evident codon adaptation to vertebrate hosts, particularly for the green African monkey Chlorocebus aethiops. PCA and CAI analyses at the individual ZIKV gene level for both human and Aedes aegypti indicated a clear distinction between the two genotypes. African ZIKV isolates showed higher virulence in mosquito cells than in vertebrate cells. Their higher replication in mosquito cells than African YFV confirmed the role of mosquitoes in the natural maintenance of the African genotype ZIKV. An analysis of individual strain growth characteristics indicated that the widely used reference strain MR766 replicates poorly in comparison to African ZIKV isolates. The recombinant African Zika virus strain ArD128000*E/NS5 may be a good model to include in studies on the mechanism of host tropism, as it cannot replicate in the tested vertebrate cell line." @default.
- W3100130106 created "2020-11-23" @default.
- W3100130106 creator A5021200960 @default.
- W3100130106 creator A5022439391 @default.
- W3100130106 creator A5031547375 @default.
- W3100130106 creator A5067866057 @default.
- W3100130106 creator A5074825308 @default.
- W3100130106 creator A5080293807 @default.
- W3100130106 creator A5082053897 @default.
- W3100130106 creator A5086153781 @default.
- W3100130106 date "2020-11-14" @default.
- W3100130106 modified "2023-09-24" @default.
- W3100130106 title "Biological Characteristics and Patterns of Codon Usage Evolution for the African Genotype Zika Virus" @default.
- W3100130106 cites W1558143285 @default.
- W3100130106 cites W1567194265 @default.
- W3100130106 cites W1957261497 @default.
- W3100130106 cites W1964006208 @default.
- W3100130106 cites W1973619678 @default.
- W3100130106 cites W1975120587 @default.
- W3100130106 cites W1979001015 @default.
- W3100130106 cites W1985048046 @default.
- W3100130106 cites W1987858500 @default.
- W3100130106 cites W1999291173 @default.
- W3100130106 cites W1999927176 @default.
- W3100130106 cites W2012210128 @default.
- W3100130106 cites W2018330825 @default.
- W3100130106 cites W2018590530 @default.
- W3100130106 cites W2023100352 @default.
- W3100130106 cites W2030178550 @default.
- W3100130106 cites W2042530028 @default.
- W3100130106 cites W2046998617 @default.
- W3100130106 cites W2051043527 @default.
- W3100130106 cites W2052056237 @default.
- W3100130106 cites W2052893935 @default.
- W3100130106 cites W2063140977 @default.
- W3100130106 cites W2065276673 @default.
- W3100130106 cites W2073049582 @default.
- W3100130106 cites W2077753994 @default.
- W3100130106 cites W2085335543 @default.
- W3100130106 cites W2098466396 @default.
- W3100130106 cites W2098902465 @default.
- W3100130106 cites W2117649585 @default.
- W3100130106 cites W2120455580 @default.
- W3100130106 cites W2122349387 @default.
- W3100130106 cites W2137005573 @default.
- W3100130106 cites W2138527314 @default.
- W3100130106 cites W2140870757 @default.
- W3100130106 cites W2142371145 @default.
- W3100130106 cites W2144870003 @default.
- W3100130106 cites W2152546486 @default.
- W3100130106 cites W2162209992 @default.
- W3100130106 cites W2163412375 @default.
- W3100130106 cites W2168518217 @default.
- W3100130106 cites W2177763207 @default.
- W3100130106 cites W2288668982 @default.
- W3100130106 cites W2290442748 @default.
- W3100130106 cites W2295378318 @default.
- W3100130106 cites W2299248163 @default.
- W3100130106 cites W2311770845 @default.
- W3100130106 cites W2322448249 @default.
- W3100130106 cites W2327959547 @default.
- W3100130106 cites W2339105112 @default.
- W3100130106 cites W2341041396 @default.
- W3100130106 cites W2341113276 @default.
- W3100130106 cites W2342621906 @default.
- W3100130106 cites W2342878920 @default.
- W3100130106 cites W2343586641 @default.
- W3100130106 cites W2395441100 @default.
- W3100130106 cites W2413814731 @default.
- W3100130106 cites W2489804474 @default.
- W3100130106 cites W2508596867 @default.
- W3100130106 cites W2513559175 @default.
- W3100130106 cites W2516492056 @default.
- W3100130106 cites W2521079522 @default.
- W3100130106 cites W2528556825 @default.
- W3100130106 cites W2530729015 @default.
- W3100130106 cites W2584547672 @default.
- W3100130106 cites W2592705911 @default.
- W3100130106 cites W2601439197 @default.
- W3100130106 cites W2603997592 @default.
- W3100130106 cites W2614980328 @default.
- W3100130106 cites W2622455794 @default.
- W3100130106 cites W2739240461 @default.
- W3100130106 cites W2750878604 @default.
- W3100130106 cites W2752631734 @default.
- W3100130106 cites W2755103072 @default.
- W3100130106 cites W2755187147 @default.
- W3100130106 cites W2760793316 @default.
- W3100130106 cites W2767681390 @default.
- W3100130106 cites W2800611010 @default.
- W3100130106 cites W2804563308 @default.
- W3100130106 cites W2805286501 @default.
- W3100130106 cites W2941046412 @default.
- W3100130106 cites W2949655112 @default.
- W3100130106 cites W2952744826 @default.
- W3100130106 doi "https://doi.org/10.3390/v12111306" @default.
- W3100130106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7696518" @default.
- W3100130106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33202554" @default.