Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100137725> ?p ?o ?g. }
- W3100137725 endingPage "3266" @default.
- W3100137725 startingPage "3249" @default.
- W3100137725 abstract "Reaction of PdCl2 with 1-methyl-1H-1,2,3,4-tetrazole-5-thiol (Hmtzt) in the presence of 5,5′-dimethyl-2,2′-bipyridine (5,5′-dmbipy) and 4,4′-dimethyl-2,2′-bipyridine ligands (4,4′-dmbipy) afforded two new Pd(II) complexes, [Pd(5,5′-dmbipy)(mtzt)2] (1) and [Pd(4,4′-dmbipy)(mtzt)2] (2), respectively. The two complexes were thoroughly characterized by elemental analysis, UV-vis, 1H NMR, IR, luminescence spectroscopy as well as single-crystal X-ray diffraction. Single-crystal X-ray diffraction revealed that central Pd(II) ions in 1 and 2 are tetra-coordinated, presenting distorted and slightly distorted square planar geometry around Pd atom for 1 and 2, respectively. The luminescence properties of free ligands and complexes 1 and 2, in solution, were investigated. The biological evaluation of the Pd(II) complexes showed that they exhibited anticancer activities in a dose-dependent manner against human breast cancer cell lines. Also, their in vitro interaction with DNA were analyzed through spectrophotometric, spectrofluorometric, and gel-electrophoresis which shows the intercalation mode of binding. In conclusion, these palladium complexes represent novel anticancer drug molecules for further study." @default.
- W3100137725 created "2020-11-23" @default.
- W3100137725 creator A5000147870 @default.
- W3100137725 creator A5021178777 @default.
- W3100137725 creator A5036295389 @default.
- W3100137725 creator A5053831758 @default.
- W3100137725 creator A5069247220 @default.
- W3100137725 creator A5074722370 @default.
- W3100137725 date "2020-11-10" @default.
- W3100137725 modified "2023-10-13" @default.
- W3100137725 title "Synthesis, crystal structures and biological activity of palladium(II) complexes with 1-methyl-1H-1,2,3,4-tetrazole-5-thiol and substituted 2,2′-bipyridines" @default.
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- W3100137725 doi "https://doi.org/10.1080/00958972.2020.1844883" @default.