Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100146807> ?p ?o ?g. }
- W3100146807 endingPage "30648" @default.
- W3100146807 startingPage "30639" @default.
- W3100146807 abstract "Significance Identifying signaling pathways contributing to resistance to anti-TNF therapy in rheumatoid arthritis is crucial for the development of new therapeutic strategies for refractory rheumatoid arthritis. Th17 cells, a subset of proinflammatory CD4 + T cells, are implicated in the pathogenesis of the disease. We analyzed the gene expression profiles of Th17-enriched CD4 + T cells in anti-TNF–treated patients with rheumatoid arthritis and found that the elevated expression levels of transcription factor USF2 in anti-TNF refractory patients were associated with increased proinflammatory signaling of Th17 cells. USF2-knockdown experiments in Th17 cells revealed that USF2 promotes the pathogenicity of Th17 cells. These findings have implications for the development of new therapeutic strategies for refractory rheumatoid arthritis." @default.
- W3100146807 created "2020-11-23" @default.
- W3100146807 creator A5006407011 @default.
- W3100146807 creator A5020675055 @default.
- W3100146807 creator A5040483846 @default.
- W3100146807 creator A5043858638 @default.
- W3100146807 creator A5050652958 @default.
- W3100146807 creator A5066540554 @default.
- W3100146807 creator A5066817176 @default.
- W3100146807 creator A5069092257 @default.
- W3100146807 creator A5075133384 @default.
- W3100146807 creator A5078975145 @default.
- W3100146807 creator A5081972026 @default.
- W3100146807 date "2020-11-17" @default.
- W3100146807 modified "2023-10-01" @default.
- W3100146807 title "Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells" @default.
- W3100146807 cites W1581564829 @default.
- W3100146807 cites W1594758412 @default.
- W3100146807 cites W1895297599 @default.
- W3100146807 cites W1924258068 @default.
- W3100146807 cites W1967817189 @default.
- W3100146807 cites W1973935154 @default.
- W3100146807 cites W1976173775 @default.
- W3100146807 cites W1977859620 @default.
- W3100146807 cites W1987628377 @default.
- W3100146807 cites W2003342633 @default.
- W3100146807 cites W2004855706 @default.
- W3100146807 cites W2006249161 @default.
- W3100146807 cites W2006352454 @default.
- W3100146807 cites W2009253992 @default.
- W3100146807 cites W2009675211 @default.
- W3100146807 cites W2027653403 @default.
- W3100146807 cites W2030820156 @default.
- W3100146807 cites W2038026702 @default.
- W3100146807 cites W2070050178 @default.
- W3100146807 cites W2071530841 @default.
- W3100146807 cites W2072633203 @default.
- W3100146807 cites W2073580835 @default.
- W3100146807 cites W2078429934 @default.
- W3100146807 cites W2082480800 @default.
- W3100146807 cites W2085609593 @default.
- W3100146807 cites W2087810525 @default.
- W3100146807 cites W2092975931 @default.
- W3100146807 cites W2096839909 @default.
- W3100146807 cites W2100769961 @default.
- W3100146807 cites W2103056503 @default.
- W3100146807 cites W2107665951 @default.
- W3100146807 cites W2109525559 @default.
- W3100146807 cites W2112065614 @default.
- W3100146807 cites W2113809328 @default.
- W3100146807 cites W2117340681 @default.
- W3100146807 cites W2118794770 @default.
- W3100146807 cites W2123106337 @default.
- W3100146807 cites W2130410032 @default.
- W3100146807 cites W2132784721 @default.
- W3100146807 cites W2148740102 @default.
- W3100146807 cites W2152348310 @default.
- W3100146807 cites W2170989872 @default.
- W3100146807 cites W2178538398 @default.
- W3100146807 cites W2190558971 @default.
- W3100146807 cites W2210295781 @default.
- W3100146807 cites W2283033715 @default.
- W3100146807 cites W2345356016 @default.
- W3100146807 cites W2498052270 @default.
- W3100146807 cites W2503545256 @default.
- W3100146807 cites W252162786 @default.
- W3100146807 cites W2589082990 @default.
- W3100146807 cites W2592935721 @default.
- W3100146807 cites W2600181829 @default.
- W3100146807 cites W2604153505 @default.
- W3100146807 cites W2730737591 @default.
- W3100146807 cites W2734431490 @default.
- W3100146807 cites W2753438196 @default.
- W3100146807 cites W2766083858 @default.
- W3100146807 cites W2768663525 @default.
- W3100146807 cites W2782229974 @default.
- W3100146807 cites W2790024164 @default.
- W3100146807 cites W2792867092 @default.
- W3100146807 cites W2798037083 @default.
- W3100146807 cites W2803433102 @default.
- W3100146807 cites W2890833207 @default.
- W3100146807 cites W2938129166 @default.
- W3100146807 cites W2954168359 @default.
- W3100146807 cites W4297789560 @default.
- W3100146807 doi "https://doi.org/10.1073/pnas.2007935117" @default.
- W3100146807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7720234" @default.
- W3100146807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33203678" @default.
- W3100146807 hasPublicationYear "2020" @default.
- W3100146807 type Work @default.
- W3100146807 sameAs 3100146807 @default.
- W3100146807 citedByCount "23" @default.
- W3100146807 countsByYear W31001468072021 @default.
- W3100146807 countsByYear W31001468072022 @default.
- W3100146807 countsByYear W31001468072023 @default.
- W3100146807 crossrefType "journal-article" @default.
- W3100146807 hasAuthorship W3100146807A5006407011 @default.
- W3100146807 hasAuthorship W3100146807A5020675055 @default.
- W3100146807 hasAuthorship W3100146807A5040483846 @default.