FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100148908> ?p ?o ?g. }

• W3100148908 endingPage "222" @default.
• W3100148908 startingPage "212" @default.
• W3100148908 abstract "In thyroid carcinomas, telomerase reverse transcriptase (TERT) promoter mutations C228T and C250T predict an unfavorable clinical outcome. The analysis is particularly valuable when assessing histologically equivocal follicular thyroid tumors of uncertain malignant potential (FT-UMPs). Given recent findings of TERT promoter mutational heterogeneity in thyroid cancer, we determined the frequency of this phenomenon in FT-UMPs and minimally invasive follicular thyroid carcinomas. DNA was extracted from several tissue blocks from 16 FT-UMPs as well as 10 minimally invasive follicular thyroid carcinomas, and interrogated using Sanger sequencing as well as digital droplet PCR (ddPCR). Mutational heterogeneity was observed by Sanger sequencing in four of seven (57%) FT-UMPs. In two FT-UMPs with C228T mutations, analyses of additional blocks gave wild-type results using Sanger sequencing in one or several blocks interrogated, whereas ddPCR found low-frequency C228T mutations in one of these fractions. In two additional FT-UMPs with the C228T and C250T mutation, respectively, sequencing of additional blocks revealed the opposite mutation. Moreover, in the C250T mutated area in one of these tumors, the ddPCR displayed a co-occurring C228T mutation that failed detection through Sanger sequencing. To conclude, most TERT promoter mutated FT-UMPs display mutational heterogeneity when analyzed by Sanger sequencing, thereby emphasizing the importance of the tissue sampling process. The ddPCR technique might overcome this phenomenon because of increased sensitivity and should be considered for clinical screening purposes." @default.
• W3100148908 created "2020-11-23" @default.
• W3100148908 creator A5018678611 @default.
• W3100148908 creator A5043745738 @default.
• W3100148908 creator A5049703961 @default.
• W3100148908 creator A5050618133 @default.
• W3100148908 creator A5060264240 @default.
• W3100148908 creator A5067258931 @default.
• W3100148908 creator A5090330886 @default.
• W3100148908 date "2021-02-01" @default.
• W3100148908 modified "2023-10-14" @default.
• W3100148908 title "Spatial Distribution Patterns of Clinically Relevant TERT Promoter Mutations in Follicular Thyroid Tumors of Uncertain Malignant Potential" @default.
• W3100148908 cites W1556214569 @default.
• W3100148908 cites W2031978342 @default.
• W3100148908 cites W2034002680 @default.
• W3100148908 cites W2039059303 @default.
• W3100148908 cites W2042720550 @default.
• W3100148908 cites W2057613360 @default.
• W3100148908 cites W2102146456 @default.
• W3100148908 cites W2128759079 @default.
• W3100148908 cites W2128839883 @default.
• W3100148908 cites W2138713106 @default.
• W3100148908 cites W2143670514 @default.
• W3100148908 cites W2225849677 @default.
• W3100148908 cites W2279570938 @default.
• W3100148908 cites W2332388546 @default.
• W3100148908 cites W2621007532 @default.
• W3100148908 cites W2737662446 @default.
• W3100148908 cites W2766244926 @default.
• W3100148908 cites W2768507008 @default.
• W3100148908 cites W2792088630 @default.
• W3100148908 cites W2800718041 @default.
• W3100148908 cites W2801328969 @default.
• W3100148908 cites W2802545098 @default.
• W3100148908 cites W2803928935 @default.
• W3100148908 cites W2805669612 @default.
• W3100148908 cites W2884169307 @default.
• W3100148908 cites W2888285899 @default.
• W3100148908 cites W2900078105 @default.
• W3100148908 cites W2910707753 @default.
• W3100148908 cites W2915242132 @default.
• W3100148908 cites W2946979733 @default.
• W3100148908 cites W2947860943 @default.
• W3100148908 cites W2947962595 @default.
• W3100148908 cites W2971151221 @default.
• W3100148908 cites W2976335008 @default.
• W3100148908 cites W2980686639 @default.
• W3100148908 cites W2982062234 @default.
• W3100148908 cites W2998775080 @default.
• W3100148908 cites W2999767923 @default.
• W3100148908 cites W3004727409 @default.
• W3100148908 cites W3015742956 @default.
• W3100148908 doi "https://doi.org/10.1016/j.jmoldx.2020.10.016" @default.
• W3100148908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33197629" @default.
• W3100148908 hasPublicationYear "2021" @default.
• W3100148908 type Work @default.
• W3100148908 sameAs 3100148908 @default.
• W3100148908 citedByCount "12" @default.
• W3100148908 countsByYear W31001489082021 @default.
• W3100148908 countsByYear W31001489082022 @default.
• W3100148908 countsByYear W31001489082023 @default.
• W3100148908 crossrefType "journal-article" @default.
• W3100148908 hasAuthorship W3100148908A5018678611 @default.
• W3100148908 hasAuthorship W3100148908A5043745738 @default.
• W3100148908 hasAuthorship W3100148908A5049703961 @default.
• W3100148908 hasAuthorship W3100148908A5050618133 @default.
• W3100148908 hasAuthorship W3100148908A5060264240 @default.
• W3100148908 hasAuthorship W3100148908A5067258931 @default.
• W3100148908 hasAuthorship W3100148908A5090330886 @default.
• W3100148908 hasBestOaLocation W31001489081 @default.
• W3100148908 hasConcept C104317684 @default.
• W3100148908 hasConcept C125593758 @default.
• W3100148908 hasConcept C2779761222 @default.
• W3100148908 hasConcept C2993294228 @default.
• W3100148908 hasConcept C501734568 @default.
• W3100148908 hasConcept C502942594 @default.
• W3100148908 hasConcept C526584372 @default.
• W3100148908 hasConcept C54355233 @default.
• W3100148908 hasConcept C76818968 @default.
• W3100148908 hasConcept C86803240 @default.
• W3100148908 hasConcept C94581717 @default.
• W3100148908 hasConceptScore W3100148908C104317684 @default.
• W3100148908 hasConceptScore W3100148908C125593758 @default.
• W3100148908 hasConceptScore W3100148908C2779761222 @default.
• W3100148908 hasConceptScore W3100148908C2993294228 @default.
• W3100148908 hasConceptScore W3100148908C501734568 @default.
• W3100148908 hasConceptScore W3100148908C502942594 @default.
• W3100148908 hasConceptScore W3100148908C526584372 @default.
• W3100148908 hasConceptScore W3100148908C54355233 @default.
• W3100148908 hasConceptScore W3100148908C76818968 @default.
• W3100148908 hasConceptScore W3100148908C86803240 @default.
• W3100148908 hasConceptScore W3100148908C94581717 @default.
• W3100148908 hasFunder F4320321491 @default.
• W3100148908 hasFunder F4320321980 @default.
• W3100148908 hasFunder F4320322128 @default.
• W3100148908 hasFunder F4320322315 @default.
• W3100148908 hasFunder F4320322570 @default.
• W3100148908 hasFunder F4320324251 @default.

• next