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- W3100152956 abstract "Parkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and, consequently, motor control. Dopaminergic degeneration is associated with the appearance of Lewy bodies, which contain membrane structures and proteins, including α-synuclein (α-Syn), in surviving neurons. PD displays a multifactorial pathology and develops from interactions between multiple elements, such as age, environmental conditions, and genetics. Mutations in the GBA1 gene represent one of the major genetic risk factors for PD. This gene encodes an essential lysosomal enzyme called β-glucocerebrosidase (GCase), which is responsible for degrading the glycolipid glucocerebroside into glucose and ceramide. GCase can generate glucosylated cholesterol via transglucosylation and can also degrade the sterol glucoside. Although the molecular mechanisms that predispose an individual to neurodegeneration remain unknown, the role of cholesterol in PD pathology deserves consideration. Disturbed cellular cholesterol metabolism, as reflected by accumulation of lysosomal cholesterol in GBA1-associated PD cellular models, could contribute to changes in lipid rafts, which are necessary for synaptic localization and vesicle cycling and modulation of synaptic integrity. α-Syn has been implicated in the regulation of neuronal cholesterol, and cholesterol facilitates interactions between α-Syn oligomers. In this review, we integrate the results of previous studies and describe the cholesterol landscape in cellular homeostasis and neuronal function. We discuss its implication in α-Syn and Lewy body pathophysiological mechanisms underlying PD, focusing on the role of GCase and cholesterol. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society" @default.
- W3100152956 created "2020-11-23" @default.
- W3100152956 creator A5012345334 @default.
- W3100152956 creator A5013935159 @default.
- W3100152956 creator A5079544290 @default.
- W3100152956 date "2020-11-21" @default.
- W3100152956 modified "2023-10-12" @default.
- W3100152956 title "The Role of Cholesterol in <scp>α‐Synuclein</scp> and Lewy Body Pathology in <scp> <i>GBA1</i> </scp> Parkinson's Disease" @default.
- W3100152956 cites W123992860 @default.
- W3100152956 cites W1486928237 @default.
- W3100152956 cites W1496790952 @default.
- W3100152956 cites W1508817480 @default.
- W3100152956 cites W1524423542 @default.
- W3100152956 cites W1536520187 @default.
- W3100152956 cites W1558432922 @default.
- W3100152956 cites W1594813249 @default.
- W3100152956 cites W1630241876 @default.
- W3100152956 cites W1663125803 @default.
- W3100152956 cites W1702860740 @default.
- W3100152956 cites W1775418466 @default.
- W3100152956 cites W1860081569 @default.
- W3100152956 cites W1913190924 @default.
- W3100152956 cites W1930265945 @default.
- W3100152956 cites W1968362921 @default.
- W3100152956 cites W1969461041 @default.
- W3100152956 cites W1969869131 @default.
- W3100152956 cites W1971116939 @default.
- W3100152956 cites W1975932268 @default.
- W3100152956 cites W1981725999 @default.
- W3100152956 cites W1990008286 @default.
- W3100152956 cites W1990937715 @default.
- W3100152956 cites W1992969293 @default.
- W3100152956 cites W1993629125 @default.
- W3100152956 cites W1994020466 @default.
- W3100152956 cites W1994454511 @default.
- W3100152956 cites W2001065761 @default.
- W3100152956 cites W2003326996 @default.
- W3100152956 cites W2003742510 @default.
- W3100152956 cites W2006161539 @default.
- W3100152956 cites W2007960303 @default.
- W3100152956 cites W2012650310 @default.
- W3100152956 cites W2016512153 @default.
- W3100152956 cites W2019933368 @default.
- W3100152956 cites W2023356978 @default.
- W3100152956 cites W2025872849 @default.
- W3100152956 cites W2031365272 @default.
- W3100152956 cites W2031491550 @default.
- W3100152956 cites W2033615443 @default.
- W3100152956 cites W2038391346 @default.
- W3100152956 cites W2039736612 @default.
- W3100152956 cites W2041392266 @default.
- W3100152956 cites W2042344227 @default.
- W3100152956 cites W2043492026 @default.
- W3100152956 cites W2043822937 @default.
- W3100152956 cites W2050444611 @default.
- W3100152956 cites W2055488264 @default.
- W3100152956 cites W2055683577 @default.
- W3100152956 cites W2058006650 @default.
- W3100152956 cites W2063345075 @default.
- W3100152956 cites W2063754694 @default.
- W3100152956 cites W2064093603 @default.
- W3100152956 cites W2066374761 @default.
- W3100152956 cites W2068001820 @default.
- W3100152956 cites W2068712725 @default.
- W3100152956 cites W2074023323 @default.
- W3100152956 cites W2074838307 @default.
- W3100152956 cites W2077584190 @default.
- W3100152956 cites W2079378641 @default.
- W3100152956 cites W2084965902 @default.
- W3100152956 cites W2087510544 @default.
- W3100152956 cites W2089694009 @default.
- W3100152956 cites W2090243158 @default.
- W3100152956 cites W2092735428 @default.
- W3100152956 cites W2095704842 @default.
- W3100152956 cites W2099452979 @default.
- W3100152956 cites W2103790898 @default.
- W3100152956 cites W2105049405 @default.
- W3100152956 cites W2111056523 @default.
- W3100152956 cites W2111215816 @default.
- W3100152956 cites W2114350791 @default.
- W3100152956 cites W2114806174 @default.
- W3100152956 cites W2114899816 @default.
- W3100152956 cites W2115923704 @default.
- W3100152956 cites W2116223355 @default.
- W3100152956 cites W2116780642 @default.
- W3100152956 cites W2117842413 @default.
- W3100152956 cites W2126334077 @default.
- W3100152956 cites W2128990583 @default.
- W3100152956 cites W2131607023 @default.
- W3100152956 cites W2133837852 @default.
- W3100152956 cites W2136558879 @default.
- W3100152956 cites W2137300912 @default.
- W3100152956 cites W2144134512 @default.
- W3100152956 cites W2144502720 @default.
- W3100152956 cites W2145515423 @default.
- W3100152956 cites W2146219284 @default.
- W3100152956 cites W2149392345 @default.
- W3100152956 cites W2150983672 @default.