FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100155593> ?p ?o ?g. }

• W3100155593 endingPage "1344" @default.
• W3100155593 startingPage "1344" @default.
• W3100155593 abstract "Transfer-RNA-derived fragments (tRFs) are a class of small non-coding RNAs that are functionally different from their parental transfer RNAs (tRNAs). tRFs can regulate gene expression by several mechanisms, and are involved in a variety of pathological processes. Here, we aimed at understanding the composition and abundance of tRFs in squamous cell carcinoma of the head and neck (SCCHN), and evaluated the potential of tRFs as prognostic markers in this cancer type. We obtained tRF expression data from The Cancer Genome Atlas (TCGA) HNSC cohort (523 patients) using MINTbase v2.0, and correlated to available TCGA clinical data. RNA-binding proteins were predicted according to the calculated Position Weight Matrix (PWM) score from the RNA-Binding Protein DataBase (RBPDB). A total of 10,158 tRFs were retrieved and a high diversity in expression levels was seen. Fifteen tRFs were found to be significantly associated with overall survival (Kaplan-Meier survival analysis, log rank test p-value < 0.01). The top prognostic marker, tRF-20-S998LO9D (p < 0.001), was further measured in tumor and tumor-free samples from 16 patients with squamous cell carcinoma of the oral tongue and 12 healthy controls, and was significantly upregulated in tumor compared to matched tumor-free tongue (p < 0.001). Results suggest that tRFs are useful prognostic markers in SCCHN." @default.
• W3100155593 created "2020-11-23" @default.
• W3100155593 creator A5013133434 @default.
• W3100155593 creator A5059110216 @default.
• W3100155593 creator A5062638897 @default.
• W3100155593 creator A5066829958 @default.
• W3100155593 creator A5073708412 @default.
• W3100155593 creator A5079134978 @default.
• W3100155593 creator A5084812538 @default.
• W3100155593 creator A5091125815 @default.
• W3100155593 date "2020-11-13" @default.
• W3100155593 modified "2023-10-01" @default.
• W3100155593 title "Transfer-RNA-Derived Fragments Are Potential Prognostic Factors in Patients with Squamous Cell Carcinoma of the Head and Neck" @default.
• W3100155593 cites W1513539546 @default.
• W3100155593 cites W1810708914 @default.
• W3100155593 cites W1832399013 @default.
• W3100155593 cites W1986241711 @default.
• W3100155593 cites W1995224771 @default.
• W3100155593 cites W2022862766 @default.
• W3100155593 cites W2023910395 @default.
• W3100155593 cites W2056831129 @default.
• W3100155593 cites W2068332602 @default.
• W3100155593 cites W2078807471 @default.
• W3100155593 cites W2087921665 @default.
• W3100155593 cites W2109140791 @default.
• W3100155593 cites W2110664940 @default.
• W3100155593 cites W2117147211 @default.
• W3100155593 cites W2148224382 @default.
• W3100155593 cites W2160046825 @default.
• W3100155593 cites W2210080033 @default.
• W3100155593 cites W2303912045 @default.
• W3100155593 cites W2338525238 @default.
• W3100155593 cites W2341142076 @default.
• W3100155593 cites W2509166389 @default.
• W3100155593 cites W2557484630 @default.
• W3100155593 cites W2560885890 @default.
• W3100155593 cites W2608110242 @default.
• W3100155593 cites W2734686459 @default.
• W3100155593 cites W2765605277 @default.
• W3100155593 cites W2769036773 @default.
• W3100155593 cites W2769912973 @default.
• W3100155593 cites W2781945186 @default.
• W3100155593 cites W2782718131 @default.
• W3100155593 cites W2793226176 @default.
• W3100155593 cites W2799721388 @default.
• W3100155593 cites W2806435205 @default.
• W3100155593 cites W2924349232 @default.
• W3100155593 cites W2937316677 @default.
• W3100155593 cites W2947477242 @default.
• W3100155593 cites W2953132931 @default.
• W3100155593 cites W2953439387 @default.
• W3100155593 cites W2975832453 @default.
• W3100155593 cites W2976080196 @default.
• W3100155593 cites W2978527819 @default.
• W3100155593 cites W2995403614 @default.
• W3100155593 cites W2997271239 @default.
• W3100155593 cites W3008912231 @default.
• W3100155593 cites W3040197336 @default.
• W3100155593 cites W4293241248 @default.
• W3100155593 doi "https://doi.org/10.3390/genes11111344" @default.
• W3100155593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7698123" @default.
• W3100155593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33202812" @default.
• W3100155593 hasPublicationYear "2020" @default.
• W3100155593 type Work @default.
• W3100155593 sameAs 3100155593 @default.
• W3100155593 citedByCount "14" @default.
• W3100155593 countsByYear W31001555932021 @default.
• W3100155593 countsByYear W31001555932022 @default.
• W3100155593 countsByYear W31001555932023 @default.
• W3100155593 crossrefType "journal-article" @default.
• W3100155593 hasAuthorship W3100155593A5013133434 @default.
• W3100155593 hasAuthorship W3100155593A5059110216 @default.
• W3100155593 hasAuthorship W3100155593A5062638897 @default.
• W3100155593 hasAuthorship W3100155593A5066829958 @default.
• W3100155593 hasAuthorship W3100155593A5073708412 @default.
• W3100155593 hasAuthorship W3100155593A5079134978 @default.
• W3100155593 hasAuthorship W3100155593A5084812538 @default.
• W3100155593 hasAuthorship W3100155593A5091125815 @default.
• W3100155593 hasBestOaLocation W31001555931 @default.
• W3100155593 hasConcept C104317684 @default.
• W3100155593 hasConcept C121608353 @default.
• W3100155593 hasConcept C126322002 @default.
• W3100155593 hasConcept C142724271 @default.
• W3100155593 hasConcept C143998085 @default.
• W3100155593 hasConcept C2776530083 @default.
• W3100155593 hasConcept C2776833033 @default.
• W3100155593 hasConcept C2777546739 @default.
• W3100155593 hasConcept C2779744641 @default.
• W3100155593 hasConcept C502942594 @default.
• W3100155593 hasConcept C54355233 @default.
• W3100155593 hasConcept C67705224 @default.
• W3100155593 hasConcept C71924100 @default.
• W3100155593 hasConcept C86803240 @default.
• W3100155593 hasConceptScore W3100155593C104317684 @default.
• W3100155593 hasConceptScore W3100155593C121608353 @default.
• W3100155593 hasConceptScore W3100155593C126322002 @default.
• W3100155593 hasConceptScore W3100155593C142724271 @default.
• W3100155593 hasConceptScore W3100155593C143998085 @default.

• next