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- W3100162883 abstract "At implantation, the mouse embryo undergoes a critical transformation which requires the precise spatiotemporal control of signalling pathways necessary for morphogenesis and developmental progression. The role played by such signalling pathways during this transition are largely unexplored, due to the inaccessibility of the embryo during the implantation when it becomes engulfed by uterine tissues. Genetic studies demonstrate that mutant embryos for BMPs die around gastrulation. Here we have aimed to dissect the role of BMPs during pre-to post-implantation transition by using a protocol permitting the development of the embryo beyond implantation stages in vitro and using stem cells to mimic post-implantation tissue organisation. By assessing both the canonical and non-canonical mechanisms of BMP, we show that the loss of canonical BMP activity compromises the extra-embryonic ectoderm development. Our analyses demonstrate that BMP signalling maintains stem cell populations within both embryonic/extra-embryonic tissues during pre-to post-implantation development. These results may provide insight into the role played by BMP signalling in controlling early embryogenesis." @default.
- W3100162883 created "2020-11-23" @default.
- W3100162883 creator A5051918738 @default.
- W3100162883 creator A5062741380 @default.
- W3100162883 creator A5077025559 @default.
- W3100162883 date "2021-02-01" @default.
- W3100162883 modified "2023-10-13" @default.
- W3100162883 title "BMP signalling is required for extra-embryonic ectoderm development during pre-to-post-implantation transition of the mouse embryo" @default.
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- W3100162883 doi "https://doi.org/10.1016/j.ydbio.2020.11.005" @default.
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