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- W3100164122 abstract "Abstract Pediatric cancer treatment often involves chemotherapy and radiation, where off-target effects can include skeletal muscle decline. The effect of such treatments on juvenile skeletal muscle growth has yet to be investigated. We employed a small animal irradiator to administer fractionated hindlimb irradiation to juvenile mice bearing implanted rhabdomyosarcoma (RMS) tumors. Hindlimb-targeted irradiation (3 × 8.2 Gy) of 4-week-old mice successfully eliminated RMS tumors implanted one week prior. After establishment of this preclinical model, a cohort of tumor-bearing mice were injected with the chemotherapeutic drug, vincristine, alone or in combination with fractionated irradiation (5 × 4.8 Gy). Single myofiber analysis of fast-contracting extensor digitorum longus (EDL) and slow-contracting soleus (SOL) muscles was conducted 3 weeks post-treatment. Although a reduction in myofiber size was apparent, EDL and SOL myonuclear number were differentially affected by juvenile irradiation and/or vincristine treatment. In contrast, a decrease in myonuclear domain (myofiber volume/myonucleus) was observed regardless of muscle or treatment. Thus, inhibition of myofiber hypertrophic growth is a consistent feature of pediatric cancer treatment." @default.
- W3100164122 created "2020-11-23" @default.
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- W3100164122 date "2020-11-11" @default.
- W3100164122 modified "2023-10-10" @default.
- W3100164122 title "Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model" @default.
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- W3100164122 doi "https://doi.org/10.1038/s41598-020-75913-w" @default.
- W3100164122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7659015" @default.
- W3100164122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33177579" @default.
- W3100164122 hasPublicationYear "2020" @default.
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