Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100166572> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3100166572 endingPage "105764" @default.
- W3100166572 startingPage "105764" @default.
- W3100166572 abstract "Abstract Detection of well-studied cancer biomarkers of microRNAs (miRNAs) is very valuable for early cancer diagnosis and therapy in clinical medicine. Herein, we designed a binary C-rich functionalized palindromic hairpin probe (BC-FPHP) and employed it as the only species to amplify the common ovarian cancer biomarker of miRNA-21. The BC-FPHP is concurrently proposed with a miRNA-21 recognition loop region, a self-complementary stem region, a binary C-rich fragment at its 5′ end, and a palindromic sequence at its 3′ end. The presence of target miRNA-21 induces the configuration change of BC-FPHP. It makes the amplification event on BC-FPHP occurred without the aid of any other probes, leading to a substantial collection of binary G-quadruplex DNA motifs that can be inserted with thioflavin T (ThT) for remarkable fluorescence emission. In this system, the BC-FPHP is smartly designed with the capabilities to be self-primered, self-templated, and self-amplified, ensuring the isothermal amplification system a simple, low cost, and user-friendly detection platform for sensitive and specific detection of miRNA-21. In addition, the BC-FPHP based amplification system has been successfully used for the detection of miRNA-21 in diluted human serum samples. We envision that this work holds great potential in the early assisting screening of ovarian cancer." @default.
- W3100166572 created "2020-11-23" @default.
- W3100166572 creator A5058620628 @default.
- W3100166572 creator A5068476595 @default.
- W3100166572 creator A5075877965 @default.
- W3100166572 creator A5077224546 @default.
- W3100166572 creator A5078824152 @default.
- W3100166572 date "2021-03-01" @default.
- W3100166572 modified "2023-10-15" @default.
- W3100166572 title "Amplified collection of binary G-quadruplex on a binary C-rich functionalized palindromic hairpin probe for label-free detection of a molecular cancer biomarker of microRNA" @default.
- W3100166572 cites W2002917664 @default.
- W3100166572 cites W2042633087 @default.
- W3100166572 cites W2047535851 @default.
- W3100166572 cites W2052278446 @default.
- W3100166572 cites W2066081299 @default.
- W3100166572 cites W2079286828 @default.
- W3100166572 cites W2084689961 @default.
- W3100166572 cites W2145303234 @default.
- W3100166572 cites W2423718667 @default.
- W3100166572 cites W2462661954 @default.
- W3100166572 cites W2501013057 @default.
- W3100166572 cites W2601637906 @default.
- W3100166572 cites W2738876690 @default.
- W3100166572 cites W2907578216 @default.
- W3100166572 cites W2938518143 @default.
- W3100166572 cites W2942952423 @default.
- W3100166572 cites W2967251316 @default.
- W3100166572 cites W2986406562 @default.
- W3100166572 cites W2996513751 @default.
- W3100166572 cites W2998191723 @default.
- W3100166572 cites W4210987384 @default.
- W3100166572 cites W4237473415 @default.
- W3100166572 doi "https://doi.org/10.1016/j.microc.2020.105764" @default.
- W3100166572 hasPublicationYear "2021" @default.
- W3100166572 type Work @default.
- W3100166572 sameAs 3100166572 @default.
- W3100166572 citedByCount "1" @default.
- W3100166572 countsByYear W31001665722022 @default.
- W3100166572 crossrefType "journal-article" @default.
- W3100166572 hasAuthorship W3100166572A5058620628 @default.
- W3100166572 hasAuthorship W3100166572A5068476595 @default.
- W3100166572 hasAuthorship W3100166572A5075877965 @default.
- W3100166572 hasAuthorship W3100166572A5077224546 @default.
- W3100166572 hasAuthorship W3100166572A5078824152 @default.
- W3100166572 hasConcept C153911025 @default.
- W3100166572 hasConcept C185592680 @default.
- W3100166572 hasConcept C2781197716 @default.
- W3100166572 hasConcept C33923547 @default.
- W3100166572 hasConcept C48372109 @default.
- W3100166572 hasConcept C552990157 @default.
- W3100166572 hasConcept C55493867 @default.
- W3100166572 hasConcept C83762044 @default.
- W3100166572 hasConcept C86803240 @default.
- W3100166572 hasConcept C94375191 @default.
- W3100166572 hasConceptScore W3100166572C153911025 @default.
- W3100166572 hasConceptScore W3100166572C185592680 @default.
- W3100166572 hasConceptScore W3100166572C2781197716 @default.
- W3100166572 hasConceptScore W3100166572C33923547 @default.
- W3100166572 hasConceptScore W3100166572C48372109 @default.
- W3100166572 hasConceptScore W3100166572C552990157 @default.
- W3100166572 hasConceptScore W3100166572C55493867 @default.
- W3100166572 hasConceptScore W3100166572C83762044 @default.
- W3100166572 hasConceptScore W3100166572C86803240 @default.
- W3100166572 hasConceptScore W3100166572C94375191 @default.
- W3100166572 hasLocation W31001665721 @default.
- W3100166572 hasOpenAccess W3100166572 @default.
- W3100166572 hasPrimaryLocation W31001665721 @default.
- W3100166572 hasRelatedWork W1531601525 @default.
- W3100166572 hasRelatedWork W1990781990 @default.
- W3100166572 hasRelatedWork W2606768298 @default.
- W3100166572 hasRelatedWork W2606769243 @default.
- W3100166572 hasRelatedWork W2748952813 @default.
- W3100166572 hasRelatedWork W2899084033 @default.
- W3100166572 hasRelatedWork W2948807893 @default.
- W3100166572 hasRelatedWork W3107215456 @default.
- W3100166572 hasRelatedWork W4306660135 @default.
- W3100166572 hasRelatedWork W2778153218 @default.
- W3100166572 hasVolume "162" @default.
- W3100166572 isParatext "false" @default.
- W3100166572 isRetracted "false" @default.
- W3100166572 magId "3100166572" @default.
- W3100166572 workType "article" @default.