FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100176917> ?p ?o ?g. }

• W3100176917 abstract "Abstract Background The effectiveness of electrochemotherapy of tumors (ECT) and of irreversible electroporation ablation (IRE) depends on different mechanisms and delivery protocols. Both therapies exploit the phenomenon of electroporation of the cell membrane achieved by the exposure of the cells to a series of high-voltage electric pulses. Electroporation can be fine-tuned to be either reversible or irreversible, causing the cells to either survive the exposure (in ECT) or not (in IRE), respectively. For treatment of tissues located close to the heart (e.g., in the liver), the safety of electroporation-based therapies is ensured by synchronizing the electric pulses with the electrocardiogram. However, the use of ECT and IRE remains contraindicated for patients with implanted cardiac pacemakers if the treated tissues are located close to the heart or the pacemaker. In this study, two questions are addressed: can the electroporation pulses interfere with the pacemaker; and, can the metallic housing of the pacemaker modify the distribution of electric field in the tissue sufficiently to affect the effectiveness and safety of the therapy? Results The electroporation pulses induced significant changes in the pacemaker ventricular pacing pulse only for the electroporation pulses delivered during the pacing pulse itself. No residual effects were observed on the pacing pulses following the electroporation pulses for all tested experimental conditions. The results of numerical modeling indicate that the presence of metal-encased pacemaker in immediate vicinity of the treatment zone should not impair the intended effectiveness of ECT or IRE even when the casing is in direct contact with one of the active electrodes. Nevertheless, the contact between the casing and the active electrode should be avoided due to significant tissue heating at the site of the other active electrode for the IRE protocol and may cause the pulse generator to fail to deliver the pulses due to excessive current draw. Conclusions The observed effects of electroporation pulses delivered in close vicinity of the pacemaker or its electrodes do not indicate adverse consequences for either the function of the pacemaker or the treatment outcome. These findings should contribute to making electroporation-based treatments accessible also to patients with implanted cardiac pacemakers." @default.
• W3100176917 created "2020-11-23" @default.
• W3100176917 creator A5020019734 @default.
• W3100176917 creator A5041122012 @default.
• W3100176917 creator A5057572051 @default.
• W3100176917 creator A5071211846 @default.
• W3100176917 creator A5076904221 @default.
• W3100176917 creator A5080299663 @default.
• W3100176917 date "2020-11-16" @default.
• W3100176917 modified "2023-10-15" @default.
• W3100176917 title "Investigation of safety for electrochemotherapy and irreversible electroporation ablation therapies in patients with cardiac pacemakers" @default.
• W3100176917 cites W1813678236 @default.
• W3100176917 cites W1948456152 @default.
• W3100176917 cites W1950752262 @default.
• W3100176917 cites W1957986799 @default.
• W3100176917 cites W2012200162 @default.
• W3100176917 cites W2019410912 @default.
• W3100176917 cites W2021312203 @default.
• W3100176917 cites W2044542264 @default.
• W3100176917 cites W2102855395 @default.
• W3100176917 cites W2108938001 @default.
• W3100176917 cites W2119456602 @default.
• W3100176917 cites W2126573497 @default.
• W3100176917 cites W2138045682 @default.
• W3100176917 cites W2147314036 @default.
• W3100176917 cites W2150736824 @default.
• W3100176917 cites W2154290132 @default.
• W3100176917 cites W2162071711 @default.
• W3100176917 cites W2187203158 @default.
• W3100176917 cites W2284248080 @default.
• W3100176917 cites W2342828177 @default.
• W3100176917 cites W2497073806 @default.
• W3100176917 cites W2509371025 @default.
• W3100176917 cites W2783774933 @default.
• W3100176917 cites W2793453599 @default.
• W3100176917 cites W2902112552 @default.
• W3100176917 cites W2914340455 @default.
• W3100176917 cites W2914415769 @default.
• W3100176917 cites W2915524427 @default.
• W3100176917 cites W2917550741 @default.
• W3100176917 cites W2918742700 @default.
• W3100176917 cites W2966467412 @default.
• W3100176917 cites W2975261665 @default.
• W3100176917 cites W2983443348 @default.
• W3100176917 cites W2989632752 @default.
• W3100176917 cites W2994278681 @default.
• W3100176917 cites W3012839541 @default.
• W3100176917 cites W3021226970 @default.
• W3100176917 cites W3027655064 @default.
• W3100176917 doi "https://doi.org/10.1186/s12938-020-00827-7" @default.
• W3100176917 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7667796" @default.
• W3100176917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33198769" @default.
• W3100176917 hasPublicationYear "2020" @default.
• W3100176917 type Work @default.
• W3100176917 sameAs 3100176917 @default.
• W3100176917 citedByCount "7" @default.
• W3100176917 countsByYear W31001769172021 @default.
• W3100176917 countsByYear W31001769172022 @default.
• W3100176917 countsByYear W31001769172023 @default.
• W3100176917 crossrefType "journal-article" @default.
• W3100176917 hasAuthorship W3100176917A5020019734 @default.
• W3100176917 hasAuthorship W3100176917A5041122012 @default.
• W3100176917 hasAuthorship W3100176917A5057572051 @default.
• W3100176917 hasAuthorship W3100176917A5071211846 @default.
• W3100176917 hasAuthorship W3100176917A5076904221 @default.
• W3100176917 hasAuthorship W3100176917A5080299663 @default.
• W3100176917 hasBestOaLocation W31001769171 @default.
• W3100176917 hasConcept C104317684 @default.
• W3100176917 hasConcept C119599485 @default.
• W3100176917 hasConcept C127413603 @default.
• W3100176917 hasConcept C136229726 @default.
• W3100176917 hasConcept C164705383 @default.
• W3100176917 hasConcept C165801399 @default.
• W3100176917 hasConcept C185592680 @default.
• W3100176917 hasConcept C186852380 @default.
• W3100176917 hasConcept C192562407 @default.
• W3100176917 hasConcept C2777108052 @default.
• W3100176917 hasConcept C2778716261 @default.
• W3100176917 hasConcept C2778902805 @default.
• W3100176917 hasConcept C2780167933 @default.
• W3100176917 hasConcept C55493867 @default.
• W3100176917 hasConcept C71924100 @default.
• W3100176917 hasConceptScore W3100176917C104317684 @default.
• W3100176917 hasConceptScore W3100176917C119599485 @default.
• W3100176917 hasConceptScore W3100176917C127413603 @default.
• W3100176917 hasConceptScore W3100176917C136229726 @default.
• W3100176917 hasConceptScore W3100176917C164705383 @default.
• W3100176917 hasConceptScore W3100176917C165801399 @default.
• W3100176917 hasConceptScore W3100176917C185592680 @default.
• W3100176917 hasConceptScore W3100176917C186852380 @default.
• W3100176917 hasConceptScore W3100176917C192562407 @default.
• W3100176917 hasConceptScore W3100176917C2777108052 @default.
• W3100176917 hasConceptScore W3100176917C2778716261 @default.
• W3100176917 hasConceptScore W3100176917C2778902805 @default.
• W3100176917 hasConceptScore W3100176917C2780167933 @default.
• W3100176917 hasConceptScore W3100176917C55493867 @default.
• W3100176917 hasConceptScore W3100176917C71924100 @default.
• W3100176917 hasFunder F4320322554 @default.
• W3100176917 hasIssue "1" @default.
• W3100176917 hasLocation W31001769171 @default.

• next