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- W3100180692 abstract "Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1-3. The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)4-7. RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19." @default.
- W3100180692 created "2020-11-23" @default.
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- W3100180692 date "2020-11-18" @default.
- W3100180692 modified "2023-10-09" @default.
- W3100180692 title "Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19" @default.
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- W3100180692 doi "https://doi.org/10.1038/s41590-020-00832-x" @default.
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- W3100180692 hasPublicationYear "2020" @default.