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• W3100183790 abstract "Sexual minority men (SMM) remain at high risk of HIV infection in the United States, and for those in relationships, dyadic functioning may contextualize prevention decisions. Pre-exposure prophylaxis (PrEP) for HIV prevention was previously limited to tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) until the FDA approved tenofovir alafenamide/FTC (TAF/FTC) for PrEP in 2019. Data regarding substance use, sexual behavior, holding an active PrEP prescription, and type of PrEP regimen (TDF/FTC versus TAF/FTC) were analyzed from a sample of 421 partnered SMM. The majority of the sample on PrEP reported a TDF/FTC prescription as opposed to TAF/FTC. However, SMM reported significantly better adherence to TAF/FTC than TDF/FTC in multivariable models. Novelty of TAF/FTC, treatment fatigue with TDF/FTC, and/or a belief in TAF/FTC's superior efficacy and mitigated side effects may be plausible contributing factors. More studies using objective adherence metrics and surveys are needed.Los hombres de minorías sexuales (SMM, por sus siglas en inglés) permanecen en alto riesgo de infección por VIH en los Estados Unidos y, para quienes están en una relación romántico, el funcionamiento diádico puede contextualizar las decisiones de prevención del VIH. La profilaxis previa a la exposición (PrEP) para la prevención del VIH se limitaba a tenofovir disoproxil fumarato / emtricitabina (TDF / FTC) hasta que la FDA aprobó tenofovir alafenamida / FTC (TAF / FTC) para PrEP en 2019. Datos sobre el uso de sustancias, comportamientos sexuales, teniendo una prescripción de PrEP activa, y el tipo de régimen de PrEP (TDF / FTC versus TAF / FTC) se analizaron de una muestra de 421 SMM asociados. La mayoría de la muestra que toma PrEP indicó teniendo una prescripción de TDF / FTC en lugar de TAF / FTC. Sin embargo, comparando la adherencia auto-informada, SMM indica mejor adherencia a TAF / FTC que TDF / FTC en modelos multivariables. La novedad de TAF / FTC, la fatiga del tratamiento con TDF / FTC y/o la creencia en la eficacia superior de TAF / FTC y los efectos secundarios mitigados pueden contribuir a la mejor adherencia a TAF / FTC. Se necesitan más estudios que utilicen métricas y encuestas de adherencia objetivas." @default.
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• W3100183790 date "2020-11-18" @default.
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• W3100183790 title "PrEP Demonstration Project Showed Superior Adherence with Tenofovir Alafenamide/Emtricitabine Compared to Tenofovir Disoproxil Fumarate/Emtricitabine in a Sample of Partnered Sexual Minority Men" @default.
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• W3100183790 doi "https://doi.org/10.1007/s10461-020-03095-7" @default.
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