FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100186578> ?p ?o ?g. }

• W3100186578 endingPage "634" @default.
• W3100186578 startingPage "625" @default.
• W3100186578 abstract "Gastrointestinal (GI) motility disorders are common, decreases quality of life, and imposes a substantial economic burden. YH12852 is a novel agonist of 5-hydroxytryptamine for the treatment of GI motility disorders. This phase I/IIa study assessed the tolerability, pharmacodynamic (PD) and pharmacokinetic (PK) profiles of YH12852. In the multiple dose (MD) cohort, healthy subjects and patients with functional constipation were randomized and received orally YH12852 at 0.3, 0.5, 1, 2, or 3 mg or prucalopride 2 mg or their matching placebo, once daily for 14 days after breakfast. In the multiple low-dose cohort (MLD), healthy subjects randomly received once-daily oral doses of YH12852 at 0.05 or 0.1 mg for 14 days after breakfast. Questionnaires, gastric emptying breath test for PDs, and plasma samples for PKs were collected. In the MD cohort, a total of 56 subjects (29 healthy volunteers and 27 patients with functional constipation) were randomized, of whom 48 completed the study. In the MLD cohort, a total of 16 healthy subjects were randomized, and 15 subjects completed the study. YH12852 increased the average weekly frequency of spontaneous bowel movements and loosened the stool. In addition, YH12852 increased quality of life satisfaction, and decreased severity of constipation symptom and GI symptoms. YH12852 was safe and well-tolerated up to 3 mg and showed nearly dose proportional PKs. In conclusion, YH12852 was safe and enhanced GI motility. YH12852 can be developed as an effective treatment option for GI motility disorders, including functional constipation. Further studies are warranted to confirm this possibility." @default.
• W3100186578 created "2020-11-23" @default.
• W3100186578 creator A5010136569 @default.
• W3100186578 creator A5015470229 @default.
• W3100186578 creator A5027946569 @default.
• W3100186578 creator A5043736319 @default.
• W3100186578 creator A5054399150 @default.
• W3100186578 creator A5058355869 @default.
• W3100186578 creator A5061392624 @default.
• W3100186578 creator A5063076347 @default.
• W3100186578 date "2020-11-30" @default.
• W3100186578 modified "2023-09-23" @default.
• W3100186578 title "YH12852, a Potent and Selective Receptor Agonist of 5‐hydroxytryptamine, Increased Gastrointestinal Motility in Healthy Volunteers and Patients With Functional Constipation" @default.
• W3100186578 cites W1479822772 @default.
• W3100186578 cites W1487487195 @default.
• W3100186578 cites W1501397556 @default.
• W3100186578 cites W1570135279 @default.
• W3100186578 cites W1974933124 @default.
• W3100186578 cites W1975229032 @default.
• W3100186578 cites W1984181078 @default.
• W3100186578 cites W2007666404 @default.
• W3100186578 cites W2013537099 @default.
• W3100186578 cites W2014001501 @default.
• W3100186578 cites W2023113612 @default.
• W3100186578 cites W2023618163 @default.
• W3100186578 cites W2027930413 @default.
• W3100186578 cites W2045323481 @default.
• W3100186578 cites W2052826002 @default.
• W3100186578 cites W2074190081 @default.
• W3100186578 cites W2075335843 @default.
• W3100186578 cites W2080111908 @default.
• W3100186578 cites W2100855870 @default.
• W3100186578 cites W2104057475 @default.
• W3100186578 cites W2108950000 @default.
• W3100186578 cites W2113764955 @default.
• W3100186578 cites W2118329435 @default.
• W3100186578 cites W2134032226 @default.
• W3100186578 cites W2138579314 @default.
• W3100186578 cites W2143198897 @default.
• W3100186578 cites W2154627001 @default.
• W3100186578 cites W2171748785 @default.
• W3100186578 cites W2504563199 @default.
• W3100186578 cites W2616789786 @default.
• W3100186578 cites W2768633358 @default.
• W3100186578 cites W2795923102 @default.
• W3100186578 cites W2806947584 @default.
• W3100186578 cites W3000300599 @default.
• W3100186578 doi "https://doi.org/10.1111/cts.12924" @default.
• W3100186578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7993265" @default.
• W3100186578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33202093" @default.
• W3100186578 hasPublicationYear "2020" @default.
• W3100186578 type Work @default.
• W3100186578 sameAs 3100186578 @default.
• W3100186578 citedByCount "3" @default.
• W3100186578 countsByYear W31001865782021 @default.
• W3100186578 countsByYear W31001865782022 @default.
• W3100186578 countsByYear W31001865782023 @default.
• W3100186578 crossrefType "journal-article" @default.
• W3100186578 hasAuthorship W3100186578A5010136569 @default.
• W3100186578 hasAuthorship W3100186578A5015470229 @default.
• W3100186578 hasAuthorship W3100186578A5027946569 @default.
• W3100186578 hasAuthorship W3100186578A5043736319 @default.
• W3100186578 hasAuthorship W3100186578A5054399150 @default.
• W3100186578 hasAuthorship W3100186578A5058355869 @default.
• W3100186578 hasAuthorship W3100186578A5061392624 @default.
• W3100186578 hasAuthorship W3100186578A5063076347 @default.
• W3100186578 hasBestOaLocation W31001865781 @default.
• W3100186578 hasConcept C126322002 @default.
• W3100186578 hasConcept C142724271 @default.
• W3100186578 hasConcept C197934379 @default.
• W3100186578 hasConcept C204787440 @default.
• W3100186578 hasConcept C27081682 @default.
• W3100186578 hasConcept C2778375690 @default.
• W3100186578 hasConcept C2779642851 @default.
• W3100186578 hasConcept C2781112942 @default.
• W3100186578 hasConcept C71924100 @default.
• W3100186578 hasConcept C72563966 @default.
• W3100186578 hasConcept C90924648 @default.
• W3100186578 hasConceptScore W3100186578C126322002 @default.
• W3100186578 hasConceptScore W3100186578C142724271 @default.
• W3100186578 hasConceptScore W3100186578C197934379 @default.
• W3100186578 hasConceptScore W3100186578C204787440 @default.
• W3100186578 hasConceptScore W3100186578C27081682 @default.
• W3100186578 hasConceptScore W3100186578C2778375690 @default.
• W3100186578 hasConceptScore W3100186578C2779642851 @default.
• W3100186578 hasConceptScore W3100186578C2781112942 @default.
• W3100186578 hasConceptScore W3100186578C71924100 @default.
• W3100186578 hasConceptScore W3100186578C72563966 @default.
• W3100186578 hasConceptScore W3100186578C90924648 @default.
• W3100186578 hasIssue "2" @default.
• W3100186578 hasLocation W31001865781 @default.
• W3100186578 hasLocation W31001865782 @default.
• W3100186578 hasLocation W31001865783 @default.
• W3100186578 hasLocation W31001865784 @default.
• W3100186578 hasOpenAccess W3100186578 @default.
• W3100186578 hasPrimaryLocation W31001865781 @default.
• W3100186578 hasRelatedWork W1570135279 @default.
• W3100186578 hasRelatedWork W2073032289 @default.

• next