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- W3100203077 abstract "ABSTRACT let-7 is a highly conserved microRNA with critical functions integral to cell fate specification and developmental progression in diverse animals. In Caenorhabditis elegans, let-7 is a component of the heterochronic (developmental timing) gene regulatory network, and loss-of-function mutations of let-7 result in lethality during the larval to adult transition due to misregulation of the conserved let-7 target, lin-41 . To date, no bilaterian animal lacking let-7 has been characterized. In this study, we identify a cohort of nematode species within the genus Caenorhabditis , closely related to C. elegans , that lack the let-7 microRNA, owing to absence of the let-7 gene. Using C. sulstoni as a representative let-7 -lacking species to characterize normal larval development in the absence of let-7 , we demonstrate that, except for the lack of let-7 , the heterochronic gene network is otherwise functionally conserved. We also report that species lacking let-7 contain a group of divergent let-7 orthologs -- also known as the let-7-family of microRNAs -- that have apparently assumed the role of targeting the lin-41 mRNA. Summary Statement We have identified a group of Caenorhabditis species that lack let-7a , an otherwise highly conserved and nearly ubiquitous microRNA that was previously thought to be critical to bilaterian animal development." @default.
- W3100203077 created "2020-11-23" @default.
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- W3100203077 date "2020-11-11" @default.
- W3100203077 modified "2023-10-03" @default.
- W3100203077 title "A cohort of Caenorhabditis species lacking the highly conserved let-7 microRNA" @default.
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- W3100203077 doi "https://doi.org/10.1101/2020.11.10.377101" @default.
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