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• W3100220025 abstract "Axonal dystrophy, indicative of perturbed axonal transport, occurs early during Alzheimer's disease (AD) pathogenesis. Little is known about the mechanisms underlying this initial sign of the pathology. This study proves that Golgi-localized γ-ear-containing ARF binding protein 3 (GGA3) loss of function, due to Gga3 genetic deletion or a GGA3 rare variant that cosegregates with late-onset AD, disrupts the axonal trafficking of the β-site APP-cleaving enzyme 1 (BACE1) resulting in its accumulation in axonal swellings in cultured neurons and in vivo. We show that BACE pharmacological inhibition ameliorates BACE1 axonal trafficking and diminishes axonal dystrophies in Gga3 null neurons in vitro and in vivo. These data indicate that axonal accumulation of BACE1 engendered by GGA3 loss of function results in local toxicity leading to axonopathy. Gga3 deletion exacerbates axonal dystrophies in a mouse model of AD before β-amyloid (Aβ) deposition. Our study strongly supports a role for GGA3 in AD pathogenesis, where GGA3 loss of function triggers BACE1 axonal accumulation independently of extracellular Aβ, and initiates a cascade of events leading to the axonal damage distinctive of the early stage of AD." @default.
• W3100220025 created "2020-11-23" @default.
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• W3100220025 date "2020-11-18" @default.
• W3100220025 modified "2023-09-24" @default.
• W3100220025 title "<i>Gga3</i> deletion and a <i>GGA3</i> rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings" @default.
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• W3100220025 doi "https://doi.org/10.1126/scitranslmed.aba1871" @default.
• W3100220025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8612295" @default.
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