FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100227119> ?p ?o ?g. }

• W3100227119 abstract "Abstract Hyper-activated LRRK2 is linked to Parkinson’s disease susceptibility and progression. Quantitative measures of LRRK2 inhibition, especially in the brain, maybe critical in the development of successful LRRK2-targeting therapeutics. In this study, two different brain-penetrant and selective LRRK2 small-molecule kinase inhibitors (PFE-360 and MLi2) were orally administered to groups of cynomolgus macaques. Proposed pharmacodynamic markers in exosomes from urine and cerebrospinal fluid (CSF) were compared to established markers in peripheral blood mononuclear cells (PBMCs). LRRK2 kinase inhibition led to reductions in exosome-LRRK2 protein and the LRRK2-substrate pT73-Rab10 in urine, as well as reduced exosome-LRRK2 and autophosphorylated pS1292-LRRK2 protein in CSF. We propose orthogonal markers for LRRK2 inhibition in urine and CSF can be used in combination with blood markers to non-invasively monitor the potency of LRRK2-targeting therapeutics." @default.
• W3100227119 created "2020-11-23" @default.
• W3100227119 creator A5018228116 @default.
• W3100227119 creator A5035195373 @default.
• W3100227119 creator A5071278272 @default.
• W3100227119 creator A5075768239 @default.
• W3100227119 creator A5090488994 @default.
• W3100227119 date "2020-11-13" @default.
• W3100227119 modified "2023-10-18" @default.
• W3100227119 title "Exosome markers of LRRK2 kinase inhibition" @default.
• W3100227119 cites W1544196343 @default.
• W3100227119 cites W1977391806 @default.
• W3100227119 cites W1986961354 @default.
• W3100227119 cites W2004536040 @default.
• W3100227119 cites W2022483806 @default.
• W3100227119 cites W2056094172 @default.
• W3100227119 cites W2058298068 @default.
• W3100227119 cites W2071318427 @default.
• W3100227119 cites W2076888837 @default.
• W3100227119 cites W2085701543 @default.
• W3100227119 cites W2100867992 @default.
• W3100227119 cites W2136216054 @default.
• W3100227119 cites W2161392725 @default.
• W3100227119 cites W2272666074 @default.
• W3100227119 cites W2295939659 @default.
• W3100227119 cites W2472421578 @default.
• W3100227119 cites W2480556520 @default.
• W3100227119 cites W2593373447 @default.
• W3100227119 cites W2602156859 @default.
• W3100227119 cites W2742044901 @default.
• W3100227119 cites W2743091325 @default.
• W3100227119 cites W2749825835 @default.
• W3100227119 cites W2767503875 @default.
• W3100227119 cites W2767998367 @default.
• W3100227119 cites W2769156514 @default.
• W3100227119 cites W2770997070 @default.
• W3100227119 cites W2795590254 @default.
• W3100227119 cites W2802569747 @default.
• W3100227119 cites W2884363644 @default.
• W3100227119 cites W2949785308 @default.
• W3100227119 cites W3019998570 @default.
• W3100227119 cites W3048032056 @default.
• W3100227119 doi "https://doi.org/10.1038/s41531-020-00138-7" @default.
• W3100227119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7666125" @default.
• W3100227119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33298972" @default.
• W3100227119 hasPublicationYear "2020" @default.
• W3100227119 type Work @default.
• W3100227119 sameAs 3100227119 @default.
• W3100227119 citedByCount "13" @default.
• W3100227119 countsByYear W31002271192021 @default.
• W3100227119 countsByYear W31002271192022 @default.
• W3100227119 countsByYear W31002271192023 @default.
• W3100227119 crossrefType "journal-article" @default.
• W3100227119 hasAuthorship W3100227119A5018228116 @default.
• W3100227119 hasAuthorship W3100227119A5035195373 @default.
• W3100227119 hasAuthorship W3100227119A5071278272 @default.
• W3100227119 hasAuthorship W3100227119A5075768239 @default.
• W3100227119 hasAuthorship W3100227119A5090488994 @default.
• W3100227119 hasBestOaLocation W31002271191 @default.
• W3100227119 hasConcept C104317684 @default.
• W3100227119 hasConcept C126322002 @default.
• W3100227119 hasConcept C137061746 @default.
• W3100227119 hasConcept C145059251 @default.
• W3100227119 hasConcept C184235292 @default.
• W3100227119 hasConcept C185592680 @default.
• W3100227119 hasConcept C202751555 @default.
• W3100227119 hasConcept C20518536 @default.
• W3100227119 hasConcept C2779134260 @default.
• W3100227119 hasConcept C2779651940 @default.
• W3100227119 hasConcept C2779734285 @default.
• W3100227119 hasConcept C2780026642 @default.
• W3100227119 hasConcept C2780427247 @default.
• W3100227119 hasConcept C2781261824 @default.
• W3100227119 hasConcept C502942594 @default.
• W3100227119 hasConcept C55493867 @default.
• W3100227119 hasConcept C71924100 @default.
• W3100227119 hasConcept C86803240 @default.
• W3100227119 hasConcept C95444343 @default.
• W3100227119 hasConcept C98274493 @default.
• W3100227119 hasConceptScore W3100227119C104317684 @default.
• W3100227119 hasConceptScore W3100227119C126322002 @default.
• W3100227119 hasConceptScore W3100227119C137061746 @default.
• W3100227119 hasConceptScore W3100227119C145059251 @default.
• W3100227119 hasConceptScore W3100227119C184235292 @default.
• W3100227119 hasConceptScore W3100227119C185592680 @default.
• W3100227119 hasConceptScore W3100227119C202751555 @default.
• W3100227119 hasConceptScore W3100227119C20518536 @default.
• W3100227119 hasConceptScore W3100227119C2779134260 @default.
• W3100227119 hasConceptScore W3100227119C2779651940 @default.
• W3100227119 hasConceptScore W3100227119C2779734285 @default.
• W3100227119 hasConceptScore W3100227119C2780026642 @default.
• W3100227119 hasConceptScore W3100227119C2780427247 @default.
• W3100227119 hasConceptScore W3100227119C2781261824 @default.
• W3100227119 hasConceptScore W3100227119C502942594 @default.
• W3100227119 hasConceptScore W3100227119C55493867 @default.
• W3100227119 hasConceptScore W3100227119C71924100 @default.
• W3100227119 hasConceptScore W3100227119C86803240 @default.
• W3100227119 hasConceptScore W3100227119C95444343 @default.
• W3100227119 hasConceptScore W3100227119C98274493 @default.
• W3100227119 hasFunder F4320337359 @default.

• next