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- W3100228897 abstract "Abstract Renshaw cells (V1 R ) are excitable as soon as they reach their final location next to the spinal motoneurons and are functionally heterogeneous. Using multiple experimental approaches, in combination with biophysical modeling and dynamical systems theory, we analyzed, for the first time, the mechanisms underlying the electrophysiological properties of V1R during early embryonic development of the spinal cord locomotor networks (E11.5-E16.5). We found that these interneurons are subdivided into several functional clusters from E11.5 and then display an unexpected transitory involution process during which they lose their ability to sustain tonic firing. We demonstrated that the essential factor controlling the diversity of the discharge pattern of embryonic V1 R is the ratio of a persistent sodium conductance to a delayed rectifier potassium conductance. Taken together, our results reveal how a simple mechanism, based on the synergy of two voltage-dependent conductances that are ubiquitous in neurons, can produce functional diversity in V1 R and control their early developmental trajectory." @default.
- W3100228897 created "2020-11-23" @default.
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- W3100228897 date "2020-06-19" @default.
- W3100228897 modified "2023-10-18" @default.
- W3100228897 title "Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity" @default.
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- W3100228897 doi "https://doi.org/10.1101/2020.06.18.158931" @default.
- W3100228897 hasPublicationYear "2020" @default.
- W3100228897 type Work @default.