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- W3100232192 abstract "A tandem cell is proposed for DNA sequencing in which an exonuclease enzyme cleaves bases (mononucleotides) from a strand of DNA for identification inside a nanopore. It has two nanopores and three compartments with the structure [cis1, upstream nanopore (UNP), trans1=cis2, downstream nanopore (DNP), trans2]. The exonuclease is attached to the exit side of UNP in trans1/cis2. A cleaved base cannot regress into cis1 because of the remaining DNA strand in UNP. A profiled electric field over DNP with positive and negative components slows down base translocation through DNP. The proposed structure is modeled with a Fokker-Planck equation and a piecewise solution presented. Results from the model indicate that with probability approaching 1 bases enter DNP in their natural order, are detected without any loss, and do not regress into DNP after progressing into trans2. Sequencing efficiency with a tandem cell would then be determined solely by the level of discrimination among the base types inside DNP." @default.
- W3100232192 created "2020-11-23" @default.
- W3100232192 creator A5086096412 @default.
- W3100232192 date "2014-06-04" @default.
- W3100232192 modified "2023-09-25" @default.
- W3100232192 title "A Tandem Cell for Nanopore-based DNA Sequencing with Exonuclease" @default.
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- W3100232192 doi "https://doi.org/10.1101/005934" @default.
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