Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100242308> ?p ?o ?g. }
- W3100242308 abstract "Abstract The proton-gated acid-sensing ion channel 1a (ASIC1a) is implicated in the injury response to cerebral ischemia but little is known about its role in cardiac ischemia. We provide genetic evidence that ASIC1a is involved in myocardial ischemia-reperfusion injury (IRI) and show that pharmacological inhibition of ASIC1a yields robust cardioprotection in rodent and human models of cardiac ischemia, resulting in improved post-IRI cardiac viability and function. Consistent with a key role for ASIC1a in cardiac ischemia, we show that polymorphisms in the ASIC1 genetic locus are strongly associated with myocardial infarction. Collectively, our data provide compelling evidence that ASIC1a is a key target for cardioprotective drugs to reduce the burden of disease associated with myocardial ischemia." @default.
- W3100242308 created "2020-11-23" @default.
- W3100242308 creator A5000570545 @default.
- W3100242308 creator A5001603007 @default.
- W3100242308 creator A5003199987 @default.
- W3100242308 creator A5004008884 @default.
- W3100242308 creator A5005645647 @default.
- W3100242308 creator A5007592145 @default.
- W3100242308 creator A5012200757 @default.
- W3100242308 creator A5023041111 @default.
- W3100242308 creator A5031451463 @default.
- W3100242308 creator A5031468937 @default.
- W3100242308 creator A5039138781 @default.
- W3100242308 creator A5042785839 @default.
- W3100242308 creator A5044523050 @default.
- W3100242308 creator A5046991564 @default.
- W3100242308 creator A5047695092 @default.
- W3100242308 creator A5048600861 @default.
- W3100242308 creator A5049624485 @default.
- W3100242308 creator A5050265631 @default.
- W3100242308 creator A5061787466 @default.
- W3100242308 creator A5065322681 @default.
- W3100242308 creator A5066568424 @default.
- W3100242308 creator A5069339861 @default.
- W3100242308 creator A5070595631 @default.
- W3100242308 creator A5074219458 @default.
- W3100242308 creator A5074282536 @default.
- W3100242308 creator A5075877219 @default.
- W3100242308 creator A5079972725 @default.
- W3100242308 creator A5082078926 @default.
- W3100242308 creator A5083830380 @default.
- W3100242308 creator A5087836581 @default.
- W3100242308 date "2019-12-10" @default.
- W3100242308 modified "2023-09-26" @default.
- W3100242308 title "Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injury" @default.
- W3100242308 cites W1535877177 @default.
- W3100242308 cites W1857861827 @default.
- W3100242308 cites W1901178709 @default.
- W3100242308 cites W1974338675 @default.
- W3100242308 cites W1982715383 @default.
- W3100242308 cites W1991997670 @default.
- W3100242308 cites W1994636585 @default.
- W3100242308 cites W2003077765 @default.
- W3100242308 cites W2003418092 @default.
- W3100242308 cites W2005960433 @default.
- W3100242308 cites W2006307209 @default.
- W3100242308 cites W2011240126 @default.
- W3100242308 cites W2015725815 @default.
- W3100242308 cites W2016450828 @default.
- W3100242308 cites W2031600355 @default.
- W3100242308 cites W2034194515 @default.
- W3100242308 cites W2042367273 @default.
- W3100242308 cites W2049778688 @default.
- W3100242308 cites W2066690328 @default.
- W3100242308 cites W2068354689 @default.
- W3100242308 cites W2069990315 @default.
- W3100242308 cites W2071518542 @default.
- W3100242308 cites W2074147910 @default.
- W3100242308 cites W2075127809 @default.
- W3100242308 cites W2085805107 @default.
- W3100242308 cites W2086688096 @default.
- W3100242308 cites W2090630995 @default.
- W3100242308 cites W2097620703 @default.
- W3100242308 cites W2098635886 @default.
- W3100242308 cites W2102522097 @default.
- W3100242308 cites W2108367699 @default.
- W3100242308 cites W2120312774 @default.
- W3100242308 cites W2142210445 @default.
- W3100242308 cites W2156077380 @default.
- W3100242308 cites W2159499909 @default.
- W3100242308 cites W2166990751 @default.
- W3100242308 cites W2167279371 @default.
- W3100242308 cites W2168048360 @default.
- W3100242308 cites W2176145961 @default.
- W3100242308 cites W2179438025 @default.
- W3100242308 cites W2200357463 @default.
- W3100242308 cites W2224985455 @default.
- W3100242308 cites W2228774679 @default.
- W3100242308 cites W2281735941 @default.
- W3100242308 cites W2339831398 @default.
- W3100242308 cites W2514447495 @default.
- W3100242308 cites W2521467817 @default.
- W3100242308 cites W2536647245 @default.
- W3100242308 cites W2582863433 @default.
- W3100242308 cites W2599431463 @default.
- W3100242308 cites W2603933399 @default.
- W3100242308 cites W2610602137 @default.
- W3100242308 cites W2615566308 @default.
- W3100242308 cites W2738643992 @default.
- W3100242308 cites W2742818597 @default.
- W3100242308 cites W2791863121 @default.
- W3100242308 cites W2792078643 @default.
- W3100242308 cites W2803848956 @default.
- W3100242308 cites W2885606882 @default.
- W3100242308 cites W2895606183 @default.
- W3100242308 cites W2900374160 @default.
- W3100242308 cites W2908414850 @default.
- W3100242308 cites W2908691941 @default.
- W3100242308 cites W2909233955 @default.
- W3100242308 cites W2911881079 @default.