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• W3100242671 abstract "Cytosine methylation has been found to play a crucial role in various biological processes, including a number of human diseases. The detection of this small modification remains challenging. In this work, we computationally explore the possibility of detecting methylated DNA strands through direct electrical conductance measurements. Using density functional theory and the Landauer-Buttiker method, we study the electronic properties and charge transport through an eight base-pair methylated DNA strand and its native counterpart. We first analyze the effect of cytosine methylation on the tight-binding parameters of two DNA strands and then model the transmission of the electrons and conductance through the strands both with and without decoherence. We find that the main difference of the tight-binding parameters between the native DNA and the methylated DNA lies in the on-site energies of (methylated) cytosine bases. The intra- and inter- strand hopping integrals between two nearest neighboring guanine base and (methylated) cytosine base also change with the addition of the methyl groups. Our calculations show that in the phase-coherent limit, the transmission of the methylated strand is close to the native strand when the energy is nearby the highest occupied molecular orbital level and larger than the native strand by 5 times in the bandgap. The trend in transmission also holds in the presence of the decoherence with the same rate. The lower conductance for the methylated strand in the experiment is suggested to be caused by the more stable structure due to the introduction of the methyl groups. We also study the role of the exchangecorrelation functional and the effect of contact coupling by choosing coupling strengths ranging from weak to strong coupling limit." @default.
• W3100242671 created "2020-11-23" @default.
• W3100242671 creator A5016460436 @default.
• W3100242671 creator A5042193329 @default.
• W3100242671 creator A5057917557 @default.
• W3100242671 date "2015-09-04" @default.
• W3100242671 modified "2023-10-14" @default.
• W3100242671 title "The role of cytosine methylation on charge transport through a DNA strand" @default.
• W3100242671 cites W1965970372 @default.
• W3100242671 cites W1966497102 @default.
• W3100242671 cites W1968263601 @default.
• W3100242671 cites W1972334400 @default.
• W3100242671 cites W1975511585 @default.
• W3100242671 cites W1976344782 @default.
• W3100242671 cites W1980454662 @default.
• W3100242671 cites W1981197560 @default.
• W3100242671 cites W1982010612 @default.
• W3100242671 cites W1984807040 @default.
• W3100242671 cites W1986046657 @default.
• W3100242671 cites W1986698926 @default.
• W3100242671 cites W1988550390 @default.
• W3100242671 cites W1993527536 @default.
• W3100242671 cites W1995910989 @default.
• W3100242671 cites W1996472831 @default.
• W3100242671 cites W2002439327 @default.
• W3100242671 cites W2004024292 @default.
• W3100242671 cites W2004078197 @default.
• W3100242671 cites W2006418071 @default.
• W3100242671 cites W2010660548 @default.
• W3100242671 cites W2013730238 @default.
• W3100242671 cites W2015347426 @default.
• W3100242671 cites W2017515560 @default.
• W3100242671 cites W2017629110 @default.
• W3100242671 cites W2020141291 @default.
• W3100242671 cites W2022985780 @default.
• W3100242671 cites W2023271753 @default.
• W3100242671 cites W2024241029 @default.
• W3100242671 cites W2025299424 @default.
• W3100242671 cites W2026150972 @default.
• W3100242671 cites W2026625428 @default.
• W3100242671 cites W2028396653 @default.
• W3100242671 cites W2028463335 @default.
• W3100242671 cites W2030262793 @default.
• W3100242671 cites W2030734005 @default.
• W3100242671 cites W2031343372 @default.
• W3100242671 cites W2034057013 @default.
• W3100242671 cites W2035375497 @default.
• W3100242671 cites W2036193631 @default.
• W3100242671 cites W2036730221 @default.
• W3100242671 cites W2037955711 @default.
• W3100242671 cites W2041948595 @default.
• W3100242671 cites W2042404608 @default.
• W3100242671 cites W2046241907 @default.
• W3100242671 cites W2046387526 @default.
• W3100242671 cites W2046412723 @default.
• W3100242671 cites W2048576571 @default.
• W3100242671 cites W2056360984 @default.
• W3100242671 cites W2061322497 @default.
• W3100242671 cites W2062089430 @default.
• W3100242671 cites W2062852634 @default.
• W3100242671 cites W2064364774 @default.
• W3100242671 cites W2068382425 @default.
• W3100242671 cites W2072910328 @default.
• W3100242671 cites W2073105380 @default.
• W3100242671 cites W2079101324 @default.
• W3100242671 cites W2084053963 @default.
• W3100242671 cites W2084149232 @default.
• W3100242671 cites W2086782735 @default.
• W3100242671 cites W2088657506 @default.
• W3100242671 cites W2090796152 @default.
• W3100242671 cites W2090885442 @default.
• W3100242671 cites W2091802514 @default.
• W3100242671 cites W2094346973 @default.
• W3100242671 cites W2095211795 @default.
• W3100242671 cites W2098658310 @default.
• W3100242671 cites W2105564187 @default.
• W3100242671 cites W2107202213 @default.
• W3100242671 cites W2108058966 @default.
• W3100242671 cites W2111024822 @default.
• W3100242671 cites W2119715145 @default.
• W3100242671 cites W2129304503 @default.
• W3100242671 cites W2129754994 @default.
• W3100242671 cites W2143981217 @default.
• W3100242671 cites W2148284063 @default.
• W3100242671 cites W2153928007 @default.
• W3100242671 cites W2156165856 @default.
• W3100242671 cites W2157896232 @default.
• W3100242671 cites W2163128951 @default.
• W3100242671 cites W2165056748 @default.
• W3100242671 cites W2170183499 @default.
• W3100242671 cites W2319107093 @default.
• W3100242671 cites W2323921122 @default.
• W3100242671 cites W2333335030 @default.
• W3100242671 cites W3103648928 @default.
• W3100242671 cites W4254122861 @default.
• W3100242671 doi "https://doi.org/10.1063/1.4929909" @default.
• W3100242671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26342369" @default.
• W3100242671 hasPublicationYear "2015" @default.
• W3100242671 type Work @default.
• W3100242671 sameAs 3100242671 @default.

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