FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100286043> ?p ?o ?g. }

• W3100286043 endingPage "11619" @default.
• W3100286043 startingPage "11607" @default.
• W3100286043 abstract "Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed digestive cancers and the fourth leading cause of death worldwide. Long noncoding RNAs (lncRNAs) with key roles in HCC development and progression have emerged and are used in the diagnosis and prognostic prediction of HCC. The lncRNA gradually increased during hepatocarcinogenesis (GIHCG) is a novel lncRNA with aberrant expression in many tumors, but its prognostic value and biological role in HCC have not been fully studied. Thus, the aim of this study was to explore the expression pattern and potential biological role of GIHCG in HCC.The expression pattern of GIHCG in HCC was analyzed in our HCC cohort and validated in The Cancer Genome Atlas (TCGA) database. To assess the prognostic value of GIHCG, survival analyses and Cox regression analyses were carried out in two HCC cohorts. Functional enrichment analysis was used to predict the gene sets and pathways related to aberrant GIHCG expression. Furthermore, the relationship between GIHCG expression and immune infiltration in HCC was analyzed.GIHCG was highly expressed in HCC tissues compared with normal liver tissues. In addition, high GIHCG expression was significantly correlated with inferior clinicopathological characteristics and shorter survival times. High GIHCG expression was an independent prognostic factor for overall survival and disease-free survival in the HCC cohort in our center and in the TCGA-LIHC cohort. Hallmark terms such as G2M checkpoint, MYC targets and DNA repair were enriched in the GIHCG high-expression groups. High GIHCG expression negatively correlated with the infiltration of memory CD4+ and CD8+ T cells, natural killer cells, macrophages, dendritic cells, neutrophils and monocytes.The findings of our study indicate that GIHCG is a biomarker that can be used to predict the prognosis of HCC patients and is correlated with immune cell infiltration in HCC." @default.
• W3100286043 created "2020-11-23" @default.
• W3100286043 creator A5017563853 @default.
• W3100286043 creator A5036963068 @default.
• W3100286043 creator A5085936226 @default.
• W3100286043 date "2020-11-01" @default.
• W3100286043 modified "2023-10-15" @default.
• W3100286043 title "<p>Overexpression of <em>GIHCG</em> is Associated with a Poor Prognosis and Immune Infiltration in Hepatocellular Carcinoma</p>" @default.
• W3100286043 cites W1988702078 @default.
• W3100286043 cites W2032183472 @default.
• W3100286043 cites W2035618305 @default.
• W3100286043 cites W2036812273 @default.
• W3100286043 cites W2053833990 @default.
• W3100286043 cites W2068517905 @default.
• W3100286043 cites W2091161969 @default.
• W3100286043 cites W2130410032 @default.
• W3100286043 cites W2146512944 @default.
• W3100286043 cites W2230320310 @default.
• W3100286043 cites W2234453634 @default.
• W3100286043 cites W2288773605 @default.
• W3100286043 cites W2460491998 @default.
• W3100286043 cites W2461410982 @default.
• W3100286043 cites W2613842309 @default.
• W3100286043 cites W2619618599 @default.
• W3100286043 cites W2735329000 @default.
• W3100286043 cites W2781945015 @default.
• W3100286043 cites W2786099441 @default.
• W3100286043 cites W2787553551 @default.
• W3100286043 cites W2790412613 @default.
• W3100286043 cites W2802867518 @default.
• W3100286043 cites W2809844942 @default.
• W3100286043 cites W2810243214 @default.
• W3100286043 cites W2889603616 @default.
• W3100286043 cites W2889646458 @default.
• W3100286043 cites W2890715893 @default.
• W3100286043 cites W2904354433 @default.
• W3100286043 cites W2905562353 @default.
• W3100286043 cites W2910203832 @default.
• W3100286043 cites W2912541104 @default.
• W3100286043 cites W2936145997 @default.
• W3100286043 cites W2943589430 @default.
• W3100286043 cites W2949273159 @default.
• W3100286043 cites W2962785190 @default.
• W3100286043 cites W2970486139 @default.
• W3100286043 cites W2973068330 @default.
• W3100286043 cites W3000178957 @default.
• W3100286043 cites W3001898238 @default.
• W3100286043 cites W3024326007 @default.
• W3100286043 cites W3024416863 @default.
• W3100286043 cites W4210955410 @default.
• W3100286043 doi "https://doi.org/10.2147/ott.s271966" @default.
• W3100286043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7670177" @default.
• W3100286043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33209037" @default.
• W3100286043 hasPublicationYear "2020" @default.
• W3100286043 type Work @default.
• W3100286043 sameAs 3100286043 @default.
• W3100286043 citedByCount "11" @default.
• W3100286043 countsByYear W31002860432021 @default.
• W3100286043 countsByYear W31002860432022 @default.
• W3100286043 countsByYear W31002860432023 @default.
• W3100286043 crossrefType "journal-article" @default.
• W3100286043 hasAuthorship W3100286043A5017563853 @default.
• W3100286043 hasAuthorship W3100286043A5036963068 @default.
• W3100286043 hasAuthorship W3100286043A5085936226 @default.
• W3100286043 hasBestOaLocation W31002860431 @default.
• W3100286043 hasConcept C10515644 @default.
• W3100286043 hasConcept C121332964 @default.
• W3100286043 hasConcept C126322002 @default.
• W3100286043 hasConcept C143998085 @default.
• W3100286043 hasConcept C153400128 @default.
• W3100286043 hasConcept C203014093 @default.
• W3100286043 hasConcept C204232928 @default.
• W3100286043 hasConcept C2776231280 @default.
• W3100286043 hasConcept C2778019345 @default.
• W3100286043 hasConcept C3019894029 @default.
• W3100286043 hasConcept C502942594 @default.
• W3100286043 hasConcept C50382708 @default.
• W3100286043 hasConcept C71924100 @default.
• W3100286043 hasConcept C72563966 @default.
• W3100286043 hasConcept C8891405 @default.
• W3100286043 hasConcept C97355855 @default.
• W3100286043 hasConceptScore W3100286043C10515644 @default.
• W3100286043 hasConceptScore W3100286043C121332964 @default.
• W3100286043 hasConceptScore W3100286043C126322002 @default.
• W3100286043 hasConceptScore W3100286043C143998085 @default.
• W3100286043 hasConceptScore W3100286043C153400128 @default.
• W3100286043 hasConceptScore W3100286043C203014093 @default.
• W3100286043 hasConceptScore W3100286043C204232928 @default.
• W3100286043 hasConceptScore W3100286043C2776231280 @default.
• W3100286043 hasConceptScore W3100286043C2778019345 @default.
• W3100286043 hasConceptScore W3100286043C3019894029 @default.
• W3100286043 hasConceptScore W3100286043C502942594 @default.
• W3100286043 hasConceptScore W3100286043C50382708 @default.
• W3100286043 hasConceptScore W3100286043C71924100 @default.
• W3100286043 hasConceptScore W3100286043C72563966 @default.
• W3100286043 hasConceptScore W3100286043C8891405 @default.
• W3100286043 hasConceptScore W3100286043C97355855 @default.
• W3100286043 hasLocation W31002860431 @default.

• next