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- W3100309104 abstract "Abstract Background : High antibiotic consumption in pyogenic liver abscess (PLA) is unnecessary. Using the databases of two centers, we retrospectively evaluated the effects of blood culture on the exposure to carbapenems in patients with PLA. Methods : All patients diagnosed with PLA at two comprehensive tertiary care centers from 2014 to 2020 were assessed. Demographics and clinical data were analyzed, and multiple regression analysis was performed to investigate the association between blood culture and exposure to carbapenems after controlling for potential confounders. Results : Blood culture results were available in 110 (46.0%) patients, of whom 44 (40.0%) patients were tested positive on bacterial culture. The blood culture positivity rate was significantly higher in the sepsis subgroup than in the non-sepsis subgroup (58.1% vs. 32.9%, P = 0.015). The number of patients receiving carbapenems in the blood culture cohort was significantly lower than that in the other cohort (19.1% vs. 31.8%, P = 0.026). Multivariate analysis showed that patients in the blood culture group were less likely to be treated with carbapenems for >5 days than those in the unavailable blood culture group (adjusted OR = 0.33, 95% CI: 0.16–0.68, P=0.003), especially those in the sepsis subgroup (adjusted OR = 0.17, 95% CI: 0.05–0.53, P = 0.002). Conclusion : Blood culture might be associated with less carbapenem exposure, particularly in PLA complicated with sepsis. More attention should be paid to early blood cultures in the emergency setting." @default.
- W3100309104 created "2020-11-23" @default.
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- W3100309104 date "2020-11-09" @default.
- W3100309104 modified "2023-09-26" @default.
- W3100309104 title "Blood Culture Evaluation for Carbapenem Exposure in Pyogenic Liver Abscess: A Two-Center Retrospective Study" @default.
- W3100309104 doi "https://doi.org/10.21203/rs.3.rs-102320/v1" @default.
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