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• W3100323596 abstract "Abstract The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel regulator of γ-secretase through a specific interaction. This commentary highlights this exciting study and provides an updated link of γ-secretase activity to innate immunity through IFITM3." @default.
• W3100323596 created "2020-11-23" @default.
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• W3100323596 date "2020-11-12" @default.
• W3100323596 modified "2023-10-15" @default.
• W3100323596 title "Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity" @default.
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• W3100323596 doi "https://doi.org/10.1186/s13024-020-00417-0" @default.
• W3100323596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7661164" @default.
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