FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100342314> ?p ?o ?g. }

• W3100342314 abstract "An increasing body of evidence associates low vitamin D levels with increased risk of multiple sclerosis (MS), suggesting the possibility of a gene-environment interaction for this environmental factor in MS pathogenesis. Moreover, it has been shown that vitamin D downregulates major histocompatibility complex (MHC) class II expression in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. We here report about the impact of a dietary vitamin D supplementation on EAE in the rat strains having functionally relevant allelic variations in the CIITA (Mhc2ta) gene, a master regulator of MHC class II expression. Full length myelin oligodendrocyte glycoprotein (MOG)-EAE was induced in DA.PVGav1-Vra4 congenic rats harboring the Vra4 locus from PVG strain in the EAE- susceptible DA background, and compared to the parental strains. The congenic rats fed with either vitamin D supplemented, deprived or regular diet developed an intermediate clinical EAE phenotype, in contrast to DA and PVG strains. Immunopathological studies revealed vitamin D dose-dependent effect on demyelination and inflammatory infiltration of the central nervous system (CNS), expression of MHC class II and CIITA, as well as downregulation of a range of pro-inflammatory genes. Taken together, our findings demonstrate an impact of vitamin D on the target tissue pathology and peripheral immune response during EAE in DA.PVGav1-Vra4 congenic strain. Thereby, our data provide evidence of a modulatory effect of vitamin D in context of genetic variances in the Vra4 locus/Mhc2ta gene in MS-like neuroinflammation, with potential relevance for the human demyelinating disease." @default.
• W3100342314 created "2020-11-23" @default.
• W3100342314 creator A5006927570 @default.
• W3100342314 creator A5009452994 @default.
• W3100342314 creator A5013185418 @default.
• W3100342314 creator A5013215896 @default.
• W3100342314 creator A5015275115 @default.
• W3100342314 creator A5023029929 @default.
• W3100342314 creator A5038894883 @default.
• W3100342314 creator A5045148813 @default.
• W3100342314 creator A5059653212 @default.
• W3100342314 creator A5081657251 @default.
• W3100342314 creator A5082826347 @default.
• W3100342314 creator A5089309483 @default.
• W3100342314 date "2020-11-13" @default.
• W3100342314 modified "2023-10-02" @default.
• W3100342314 title "Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)" @default.
• W3100342314 cites W1785819613 @default.
• W3100342314 cites W1964890547 @default.
• W3100342314 cites W1970897847 @default.
• W3100342314 cites W1975311295 @default.
• W3100342314 cites W1976195988 @default.
• W3100342314 cites W1992695872 @default.
• W3100342314 cites W1998602982 @default.
• W3100342314 cites W1999427630 @default.
• W3100342314 cites W2013725496 @default.
• W3100342314 cites W2015865604 @default.
• W3100342314 cites W2019960970 @default.
• W3100342314 cites W2044367189 @default.
• W3100342314 cites W2049301689 @default.
• W3100342314 cites W2052910404 @default.
• W3100342314 cites W2054475366 @default.
• W3100342314 cites W2076418667 @default.
• W3100342314 cites W2091411865 @default.
• W3100342314 cites W2099126377 @default.
• W3100342314 cites W2104212738 @default.
• W3100342314 cites W2107409113 @default.
• W3100342314 cites W2109978145 @default.
• W3100342314 cites W2111480581 @default.
• W3100342314 cites W2111700032 @default.
• W3100342314 cites W2112710107 @default.
• W3100342314 cites W2116041320 @default.
• W3100342314 cites W2117784451 @default.
• W3100342314 cites W2118296597 @default.
• W3100342314 cites W2120298753 @default.
• W3100342314 cites W2134303810 @default.
• W3100342314 cites W2138258120 @default.
• W3100342314 cites W2141345239 @default.
• W3100342314 cites W2165526847 @default.
• W3100342314 cites W2166835758 @default.
• W3100342314 cites W2171457359 @default.
• W3100342314 cites W2588375385 @default.
• W3100342314 cites W2739441634 @default.
• W3100342314 cites W2944359613 @default.
• W3100342314 cites W2967188367 @default.
• W3100342314 cites W2977774617 @default.
• W3100342314 cites W2981477552 @default.
• W3100342314 cites W4211048507 @default.
• W3100342314 cites W4211254511 @default.
• W3100342314 doi "https://doi.org/10.3389/fneur.2020.600401" @default.
• W3100342314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7693436" @default.
• W3100342314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33304315" @default.
• W3100342314 hasPublicationYear "2020" @default.
• W3100342314 type Work @default.
• W3100342314 sameAs 3100342314 @default.
• W3100342314 citedByCount "3" @default.
• W3100342314 countsByYear W31003423142021 @default.
• W3100342314 countsByYear W31003423142022 @default.
• W3100342314 crossrefType "journal-article" @default.
• W3100342314 hasAuthorship W3100342314A5006927570 @default.
• W3100342314 hasAuthorship W3100342314A5009452994 @default.
• W3100342314 hasAuthorship W3100342314A5013185418 @default.
• W3100342314 hasAuthorship W3100342314A5013215896 @default.
• W3100342314 hasAuthorship W3100342314A5015275115 @default.
• W3100342314 hasAuthorship W3100342314A5023029929 @default.
• W3100342314 hasAuthorship W3100342314A5038894883 @default.
• W3100342314 hasAuthorship W3100342314A5045148813 @default.
• W3100342314 hasAuthorship W3100342314A5059653212 @default.
• W3100342314 hasAuthorship W3100342314A5081657251 @default.
• W3100342314 hasAuthorship W3100342314A5082826347 @default.
• W3100342314 hasAuthorship W3100342314A5089309483 @default.
• W3100342314 hasBestOaLocation W31003423141 @default.
• W3100342314 hasConcept C104317684 @default.
• W3100342314 hasConcept C124490489 @default.
• W3100342314 hasConcept C134018914 @default.
• W3100342314 hasConcept C203014093 @default.
• W3100342314 hasConcept C207936829 @default.
• W3100342314 hasConcept C2775890610 @default.
• W3100342314 hasConcept C2776914184 @default.
• W3100342314 hasConcept C2778486448 @default.
• W3100342314 hasConcept C2778609137 @default.
• W3100342314 hasConcept C2778814158 @default.
• W3100342314 hasConcept C2779357208 @default.
• W3100342314 hasConcept C2780640218 @default.
• W3100342314 hasConcept C529278444 @default.
• W3100342314 hasConcept C54355233 @default.
• W3100342314 hasConcept C84951073 @default.
• W3100342314 hasConcept C86803240 @default.
• W3100342314 hasConcept C87753298 @default.
• W3100342314 hasConcept C8891405 @default.

• next