Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100344342> ?p ?o ?g. }
- W3100344342 endingPage "6059" @default.
- W3100344342 startingPage "6043" @default.
- W3100344342 abstract "Neuroglial activation has been recognized as a pathological hallmark of a variety of neurological diseases, yet the role of neuroglia in tinnitus hasn't been well established so far. To explore the potential roles of two types of glia cells (astrocyte and microglia) in the development of tinnitus, we examined markers associated with them in the primary auditory (A1) cortex and medial geniculate body (MGB) of rats with salicylate-induced tinnitus. The results demonstrated that acute and chronic administrations of salicylate could cause reversible tinnitus-like behavior in rats. The expression level of GFAP markedly increased in the A1 cortex of rats following acute and chronic treatments of salicylate, accompanied by increased endpoint and process length of astrocyte. The expression level of GFAP and the morphology of astrocyte in the rat MGB remained almost constant following salicylate treatment. On the other hand, the expression level of Iba1 markedly increased in the rat A1 cortex and MGB following acute and chronic treatments of salicylate, together with increased endpoint and process length of microglia in the MGB. Additionally, interleukin 1β (IL-1β), a pro-inflammatory cytokine released by activated glia was significantly up-regulated in the A1 cortex and MGB of rats after salicylate treatments. These findings highlight astrocyte activation and microglia proliferation in the central auditory system of rats experiencing tinnitus, which potently implicate an indispensable glial regulation in tinnitus development." @default.
- W3100344342 created "2020-11-23" @default.
- W3100344342 creator A5015943195 @default.
- W3100344342 creator A5074700160 @default.
- W3100344342 creator A5076523459 @default.
- W3100344342 creator A5081980183 @default.
- W3100344342 creator A5085580215 @default.
- W3100344342 date "2020-01-01" @default.
- W3100344342 modified "2023-10-01" @default.
- W3100344342 title "Neuroglial activation in the auditory cortex and medial geniculate body of salicylate-induced tinnitus rats." @default.
- W3100344342 cites W1501639594 @default.
- W3100344342 cites W1534620902 @default.
- W3100344342 cites W1775179554 @default.
- W3100344342 cites W1857150657 @default.
- W3100344342 cites W1965100042 @default.
- W3100344342 cites W1965640980 @default.
- W3100344342 cites W1970137351 @default.
- W3100344342 cites W1973458820 @default.
- W3100344342 cites W1976130530 @default.
- W3100344342 cites W1984089779 @default.
- W3100344342 cites W1990143453 @default.
- W3100344342 cites W1990445317 @default.
- W3100344342 cites W1992498333 @default.
- W3100344342 cites W1994247895 @default.
- W3100344342 cites W1994620975 @default.
- W3100344342 cites W1996313445 @default.
- W3100344342 cites W2010150006 @default.
- W3100344342 cites W2011362027 @default.
- W3100344342 cites W2018443255 @default.
- W3100344342 cites W2020777781 @default.
- W3100344342 cites W2035605437 @default.
- W3100344342 cites W2036960554 @default.
- W3100344342 cites W2040423913 @default.
- W3100344342 cites W2041918412 @default.
- W3100344342 cites W2045550001 @default.
- W3100344342 cites W2051019934 @default.
- W3100344342 cites W2058011139 @default.
- W3100344342 cites W2066389227 @default.
- W3100344342 cites W2066943555 @default.
- W3100344342 cites W2070625437 @default.
- W3100344342 cites W2074477628 @default.
- W3100344342 cites W2076871918 @default.
- W3100344342 cites W2077427534 @default.
- W3100344342 cites W2084899362 @default.
- W3100344342 cites W2090930997 @default.
- W3100344342 cites W2097853513 @default.
- W3100344342 cites W2117324900 @default.
- W3100344342 cites W2120259661 @default.
- W3100344342 cites W2120648097 @default.
- W3100344342 cites W2134557769 @default.
- W3100344342 cites W2143980831 @default.
- W3100344342 cites W2153026104 @default.
- W3100344342 cites W2157546454 @default.
- W3100344342 cites W2252713678 @default.
- W3100344342 cites W2287844411 @default.
- W3100344342 cites W2314484574 @default.
- W3100344342 cites W2336534940 @default.
- W3100344342 cites W2415005901 @default.
- W3100344342 cites W2521126349 @default.
- W3100344342 cites W2532468046 @default.
- W3100344342 cites W2589660261 @default.
- W3100344342 cites W2623532411 @default.
- W3100344342 cites W2728496947 @default.
- W3100344342 cites W2761242880 @default.
- W3100344342 cites W2778605439 @default.
- W3100344342 cites W2790149673 @default.
- W3100344342 cites W2806300791 @default.
- W3100344342 cites W2901096548 @default.
- W3100344342 cites W2905868894 @default.
- W3100344342 cites W2924535265 @default.
- W3100344342 cites W2950278201 @default.
- W3100344342 cites W2952323977 @default.
- W3100344342 cites W2984828548 @default.
- W3100344342 cites W3006397379 @default.
- W3100344342 cites W3007594722 @default.
- W3100344342 cites W3014950787 @default.
- W3100344342 cites W3014987272 @default.
- W3100344342 cites W4249561229 @default.
- W3100344342 cites W939949054 @default.
- W3100344342 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7653558" @default.
- W3100344342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33194013" @default.
- W3100344342 hasPublicationYear "2020" @default.
- W3100344342 type Work @default.
- W3100344342 sameAs 3100344342 @default.
- W3100344342 citedByCount "7" @default.
- W3100344342 countsByYear W31003443422021 @default.
- W3100344342 countsByYear W31003443422022 @default.
- W3100344342 countsByYear W31003443422023 @default.
- W3100344342 crossrefType "journal-article" @default.
- W3100344342 hasAuthorship W3100344342A5015943195 @default.
- W3100344342 hasAuthorship W3100344342A5074700160 @default.
- W3100344342 hasAuthorship W3100344342A5076523459 @default.
- W3100344342 hasAuthorship W3100344342A5081980183 @default.
- W3100344342 hasAuthorship W3100344342A5085580215 @default.
- W3100344342 hasConcept C126322002 @default.
- W3100344342 hasConcept C134018914 @default.
- W3100344342 hasConcept C169760540 @default.
- W3100344342 hasConcept C2775980177 @default.