FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100349144> ?p ?o ?g. }

• W3100349144 abstract "Abstract The Aedes aegypti mosquito is a major vector for arboviruses including dengue, chikungunya and Zika virus. Combating the spread of these viruses requires a more complete understanding of the mosquito immune system. Recent studies have implicated genomic endogenous viral elements (EVEs) derived from non-retroviral RNA viruses in insect immunity. Because these elements are inserted into repetitive regions of the mosquito genome, their large-scale structure and organization with respect to other genomic elements has been difficult to resolve with short-read sequencing. To better define the origin, diversity and biological role of EVEs, we employed single-molecule, real-time sequencing technology to generate a high quality, long-read assembly of the Ae . aegypti -derived Aag2 cell line genome. We leverage the quality and contiguity of this assembly to characterize the diversity and genomic context of EVEs in the genome of this important model system. We find that EVEs in the Aag2 genome are acquired through recombination by LTR retrotransposons, and organize into larger loci (>50kbp) characterized by high LTR density. These EVE containing loci are associated with increased transcription factor binding sight density and increased production of anti-genomic piRNAs. We also detected piRNA processing corresponding to on-going viral infection. This global view of EVEs and piRNA responses demonstrates the ubiquity and diversity of these heritable elements that define small-RNA mediated antiviral immunity in mosquitoes." @default.
• W3100349144 created "2020-11-23" @default.
• W3100349144 creator A5006463024 @default.
• W3100349144 creator A5022164242 @default.
• W3100349144 creator A5025129760 @default.
• W3100349144 creator A5041247375 @default.
• W3100349144 creator A5044865465 @default.
• W3100349144 creator A5058949709 @default.
• W3100349144 creator A5073608094 @default.
• W3100349144 creator A5075646787 @default.
• W3100349144 creator A5091829332 @default.
• W3100349144 date "2017-04-14" @default.
• W3100349144 modified "2023-09-28" @default.
• W3100349144 title "The diversity, structure and function of heritable adaptive immunity sequences in the Aedes aegypti genome" @default.
• W3100349144 cites W1857873485 @default.
• W3100349144 cites W1904534637 @default.
• W3100349144 cites W1908905777 @default.
• W3100349144 cites W1974332832 @default.
• W3100349144 cites W1984038745 @default.
• W3100349144 cites W1984072888 @default.
• W3100349144 cites W1991140321 @default.
• W3100349144 cites W1995808663 @default.
• W3100349144 cites W2029946299 @default.
• W3100349144 cites W2039337517 @default.
• W3100349144 cites W2055508399 @default.
• W3100349144 cites W2065461553 @default.
• W3100349144 cites W2065669787 @default.
• W3100349144 cites W2068955013 @default.
• W3100349144 cites W2074897380 @default.
• W3100349144 cites W2075827435 @default.
• W3100349144 cites W2076635391 @default.
• W3100349144 cites W2087808447 @default.
• W3100349144 cites W2104024599 @default.
• W3100349144 cites W2105329815 @default.
• W3100349144 cites W2107772251 @default.
• W3100349144 cites W2109387251 @default.
• W3100349144 cites W2114853012 @default.
• W3100349144 cites W2116790929 @default.
• W3100349144 cites W2124985265 @default.
• W3100349144 cites W2125233222 @default.
• W3100349144 cites W2131222241 @default.
• W3100349144 cites W2132926880 @default.
• W3100349144 cites W2136493438 @default.
• W3100349144 cites W2145081023 @default.
• W3100349144 cites W2155414577 @default.
• W3100349144 cites W2156597566 @default.
• W3100349144 cites W2159086136 @default.
• W3100349144 cites W2161207862 @default.
• W3100349144 cites W2170430743 @default.
• W3100349144 cites W2171158206 @default.
• W3100349144 cites W2171306775 @default.
• W3100349144 cites W2190876050 @default.
• W3100349144 cites W2279483750 @default.
• W3100349144 cites W2281309807 @default.
• W3100349144 cites W2290849670 @default.
• W3100349144 cites W2394600293 @default.
• W3100349144 cites W2406404683 @default.
• W3100349144 cites W2410616080 @default.
• W3100349144 cites W2509346014 @default.
• W3100349144 cites W2516217055 @default.
• W3100349144 cites W2564097357 @default.
• W3100349144 cites W2571283472 @default.
• W3100349144 cites W2576380273 @default.
• W3100349144 cites W2951102651 @default.
• W3100349144 cites W4236236547 @default.
• W3100349144 doi "https://doi.org/10.1101/127498" @default.
• W3100349144 hasPublicationYear "2017" @default.
• W3100349144 type Work @default.
• W3100349144 sameAs 3100349144 @default.
• W3100349144 citedByCount "0" @default.
• W3100349144 crossrefType "posted-content" @default.
• W3100349144 hasAuthorship W3100349144A5006463024 @default.
• W3100349144 hasAuthorship W3100349144A5022164242 @default.
• W3100349144 hasAuthorship W3100349144A5025129760 @default.
• W3100349144 hasAuthorship W3100349144A5041247375 @default.
• W3100349144 hasAuthorship W3100349144A5044865465 @default.
• W3100349144 hasAuthorship W3100349144A5058949709 @default.
• W3100349144 hasAuthorship W3100349144A5073608094 @default.
• W3100349144 hasAuthorship W3100349144A5075646787 @default.
• W3100349144 hasAuthorship W3100349144A5091829332 @default.
• W3100349144 hasBestOaLocation W31003491441 @default.
• W3100349144 hasConcept C104317684 @default.
• W3100349144 hasConcept C121346293 @default.
• W3100349144 hasConcept C141231307 @default.
• W3100349144 hasConcept C151730666 @default.
• W3100349144 hasConcept C173758957 @default.
• W3100349144 hasConcept C2777775583 @default.
• W3100349144 hasConcept C2779343474 @default.
• W3100349144 hasConcept C54355233 @default.
• W3100349144 hasConcept C59822182 @default.
• W3100349144 hasConcept C70721500 @default.
• W3100349144 hasConcept C78458016 @default.
• W3100349144 hasConcept C86803240 @default.
• W3100349144 hasConceptScore W3100349144C104317684 @default.
• W3100349144 hasConceptScore W3100349144C121346293 @default.
• W3100349144 hasConceptScore W3100349144C141231307 @default.
• W3100349144 hasConceptScore W3100349144C151730666 @default.
• W3100349144 hasConceptScore W3100349144C173758957 @default.
• W3100349144 hasConceptScore W3100349144C2777775583 @default.
• W3100349144 hasConceptScore W3100349144C2779343474 @default.

• next