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- W3100349899 abstract "Significance Carbapenem-resistant Enterobacteriaceae (CRE) are multidrug-resistant bacterial pathogens designated as urgent threats by the US Centers for Disease Control and Prevention. Resistance to carbapenems and other antibiotics is usually carried on diverse large, low-copy-number plasmids. Interfering with the replication of such resistance plasmids could potentially restore antibiotic susceptibility. Therefore, we designed a high-throughput screen to identify compounds with anti-CRE plasmid activity. We identified several compounds which by blocking plasmid replication and/or evicting a representative IncFIA CRE plasmid potentiated carbapenem activity, thereby providing proof of principle for our approach. Our findings underscore the potential of antiplasmid therapeutics to restore treatment options for highly drug-resistant pathogens and validate a high-throughput screening approach to identify these agents." @default.
- W3100349899 created "2020-11-23" @default.
- W3100349899 creator A5016768442 @default.
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- W3100349899 date "2020-11-09" @default.
- W3100349899 modified "2023-09-23" @default.
- W3100349899 title "Discovery of small-molecule inhibitors of multidrug-resistance plasmid maintenance using a high-throughput screening approach" @default.
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- W3100349899 doi "https://doi.org/10.1073/pnas.2005948117" @default.
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