Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100352788> ?p ?o ?g. }
- W3100352788 abstract "Summary Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains superficial. Here, we firstly provide a transcriptional map of single leukocytes in CSF compared to blood. Leukocyte composition and transcriptome were compartment-specific with CSF-enrichment of myeloid dendritic cells and a border-associated phenotype of monocytes. We secondly tested how multiple sclerosis (MS) - an autoimmune disease of the CNS - affected both compartments. MS increased transcriptional diversity in blood, while it preferentially increased cell type diversity in CSF. In addition to the known expansion of B lineage cells, we identified an increase of cytotoxic-phenotype and follicular T helper (TFH) cells in the CSF. In mice, TFH cells accordingly promoted B cell infiltration into the CNS and severity of MS animal models. Immune mechanisms in MS are thus highly compartmentalized and indicate local T/B cell interaction." @default.
- W3100352788 created "2020-11-23" @default.
- W3100352788 creator A5004905245 @default.
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- W3100352788 creator A5076180609 @default.
- W3100352788 creator A5089846075 @default.
- W3100352788 creator A5091824135 @default.
- W3100352788 date "2018-08-29" @default.
- W3100352788 modified "2023-09-23" @default.
- W3100352788 title "Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis" @default.
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