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- W3100355993 abstract "Abstract The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show that cigarette smoke causes a dose-dependent upregulation of Angiotensin Converting Enzyme 2 (ACE2), the SARS-CoV-2 receptor, in rodent and human lungs. Using single-cell sequencing data, we demonstrate that ACE2 is expressed in a subset of secretory cells in the respiratory tract. Chronic smoke exposure triggers the expansion of this cell population and a concomitant increase in ACE2 expression. In contrast, quitting smoking decreases the abundance of these secretory cells and reduces ACE2 levels. Finally, we demonstrate that ACE2 expression is responsive to inflammatory signaling and can be upregulated by viral infections or interferon treatment. Taken together, these results may partially explain why smokers are particularly susceptible to severe SARS-CoV-2 infections. Furthermore, our work identifies ACE2 as an interferon-stimulated gene in lung cells, suggesting that SARS-CoV-2 infections could create positive-feedback loops that increase ACE2 levels and facilitate viral dissemination." @default.
- W3100355993 created "2020-11-23" @default.
- W3100355993 creator A5035920679 @default.
- W3100355993 creator A5036040347 @default.
- W3100355993 creator A5047464324 @default.
- W3100355993 creator A5070507037 @default.
- W3100355993 creator A5076579781 @default.
- W3100355993 creator A5091662869 @default.
- W3100355993 date "2020-03-31" @default.
- W3100355993 modified "2023-09-23" @default.
- W3100355993 title "Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract" @default.
- W3100355993 cites W1589010135 @default.
- W3100355993 cites W1845641771 @default.
- W3100355993 cites W1921824630 @default.
- W3100355993 cites W1964982019 @default.
- W3100355993 cites W1966238900 @default.
- W3100355993 cites W1973221350 @default.
- W3100355993 cites W1974431676 @default.
- W3100355993 cites W1976761409 @default.
- W3100355993 cites W1976848056 @default.
- W3100355993 cites W1978746689 @default.
- W3100355993 cites W1994123173 @default.
- W3100355993 cites W1994915168 @default.
- W3100355993 cites W1997814296 @default.
- W3100355993 cites W1999322594 @default.
- W3100355993 cites W2000571026 @default.
- W3100355993 cites W2001411396 @default.
- W3100355993 cites W2001634286 @default.
- W3100355993 cites W2007610579 @default.
- W3100355993 cites W2012034410 @default.
- W3100355993 cites W2018838463 @default.
- W3100355993 cites W2020541351 @default.
- W3100355993 cites W2021442163 @default.
- W3100355993 cites W2023080320 @default.
- W3100355993 cites W2023833569 @default.
- W3100355993 cites W2025072503 @default.
- W3100355993 cites W2026364528 @default.
- W3100355993 cites W2035756448 @default.
- W3100355993 cites W2036582717 @default.
- W3100355993 cites W2037902955 @default.
- W3100355993 cites W2043343078 @default.
- W3100355993 cites W2043398720 @default.
- W3100355993 cites W2043767564 @default.
- W3100355993 cites W2045651193 @default.
- W3100355993 cites W2047598336 @default.
- W3100355993 cites W2059121736 @default.
- W3100355993 cites W2061210530 @default.
- W3100355993 cites W2067973725 @default.
- W3100355993 cites W2068859304 @default.
- W3100355993 cites W2075383643 @default.
- W3100355993 cites W2089417149 @default.
- W3100355993 cites W2091107271 @default.
- W3100355993 cites W2091671824 @default.
- W3100355993 cites W2099156318 @default.
- W3100355993 cites W2101594367 @default.
- W3100355993 cites W2102042645 @default.
- W3100355993 cites W2103568386 @default.
- W3100355993 cites W2103649986 @default.
- W3100355993 cites W2105068554 @default.
- W3100355993 cites W2106579714 @default.
- W3100355993 cites W2108067828 @default.
- W3100355993 cites W2108859738 @default.
- W3100355993 cites W2110020755 @default.
- W3100355993 cites W2114634897 @default.
- W3100355993 cites W2122225224 @default.
- W3100355993 cites W2126557512 @default.
- W3100355993 cites W2137064182 @default.
- W3100355993 cites W2150736550 @default.
- W3100355993 cites W2152329221 @default.
- W3100355993 cites W2153310848 @default.
- W3100355993 cites W2153349010 @default.
- W3100355993 cites W2157685336 @default.
- W3100355993 cites W2158485828 @default.
- W3100355993 cites W2160103276 @default.
- W3100355993 cites W2160707122 @default.
- W3100355993 cites W2166617377 @default.
- W3100355993 cites W2167384912 @default.
- W3100355993 cites W2170478549 @default.
- W3100355993 cites W2172937773 @default.
- W3100355993 cites W2181523240 @default.
- W3100355993 cites W2342127666 @default.
- W3100355993 cites W2417018059 @default.
- W3100355993 cites W2598516749 @default.
- W3100355993 cites W2742995736 @default.
- W3100355993 cites W2747597014 @default.
- W3100355993 cites W2765822532 @default.
- W3100355993 cites W2793568682 @default.
- W3100355993 cites W2800392236 @default.
- W3100355993 cites W2802058961 @default.
- W3100355993 cites W2857568261 @default.
- W3100355993 cites W2885396126 @default.
- W3100355993 cites W2885499809 @default.
- W3100355993 cites W2887886950 @default.
- W3100355993 cites W2891636773 @default.
- W3100355993 cites W2900535696 @default.
- W3100355993 cites W2909923677 @default.
- W3100355993 cites W2940045913 @default.
- W3100355993 cites W2944545583 @default.
- W3100355993 cites W2949025403 @default.
- W3100355993 cites W2962549599 @default.