Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100364089> ?p ?o ?g. }
- W3100364089 abstract "Abstract Excitatory amino acid carrier 1 (EAAC1) is an important subtype of excitatory amino acid transporters (EAATs) and is the route for neuronal cysteine uptake. CoCl 2 is not only a hypoxia-mimetic reagent but also an oxidative stress inducer. Here, we found that CoCl 2 induced significant EAAC1 overexpression in SH-SY5Y cells and the hippocampus of mice. Transient transfection of EAAC1 reduced CoCl 2 -induced cytotoxicity in SH-SY5Y cells. Based on this result, upregulation of EAAC1 expression by CoCl 2 is thought to represent a compensatory response against oxidative stress in an acute hypoxic state. We further demonstrated that pretreatment with Neuregulin-1 (NRG1) rescued CoCl 2 -induced upregulation of EAAC1 and tau expression. NRG1 plays a protective role in the CoCl 2 -induced accumulation of reactive oxygen species (ROS) and reduction in antioxidative enzyme (SOD and GPx) activity. Moreover, NRG1 attenuated CoCl 2 -induced apoptosis and cell death. NRG1 inhibited the CoCl 2 -induced release of cleaved caspase-3 and reduction in Bcl-X L levels. Our novel finding suggests that NRG1 may play a protective role in hypoxia through the inhibition of oxidative stress and thereby maintain normal EAAC1 expression levels." @default.
- W3100364089 created "2020-11-23" @default.
- W3100364089 creator A5014807064 @default.
- W3100364089 creator A5022255280 @default.
- W3100364089 creator A5044912860 @default.
- W3100364089 creator A5052297688 @default.
- W3100364089 creator A5060418943 @default.
- W3100364089 creator A5073695220 @default.
- W3100364089 creator A5085832747 @default.
- W3100364089 creator A5086603848 @default.
- W3100364089 date "2020-11-13" @default.
- W3100364089 modified "2023-10-12" @default.
- W3100364089 title "Neuregulin-1 inhibits CoCl2-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice" @default.
- W3100364089 cites W1533853049 @default.
- W3100364089 cites W1547863599 @default.
- W3100364089 cites W1585200182 @default.
- W3100364089 cites W1893543180 @default.
- W3100364089 cites W1899746275 @default.
- W3100364089 cites W1900227502 @default.
- W3100364089 cites W1956102933 @default.
- W3100364089 cites W1970292153 @default.
- W3100364089 cites W1978147734 @default.
- W3100364089 cites W1980155257 @default.
- W3100364089 cites W1980424928 @default.
- W3100364089 cites W1989953524 @default.
- W3100364089 cites W1991202992 @default.
- W3100364089 cites W1992423329 @default.
- W3100364089 cites W1999613366 @default.
- W3100364089 cites W2003410399 @default.
- W3100364089 cites W2010131630 @default.
- W3100364089 cites W2020124645 @default.
- W3100364089 cites W2023527463 @default.
- W3100364089 cites W2025452062 @default.
- W3100364089 cites W2028002685 @default.
- W3100364089 cites W2030352252 @default.
- W3100364089 cites W2035360955 @default.
- W3100364089 cites W2039096550 @default.
- W3100364089 cites W2051176464 @default.
- W3100364089 cites W2051861534 @default.
- W3100364089 cites W2053337885 @default.
- W3100364089 cites W2062148496 @default.
- W3100364089 cites W2062754118 @default.
- W3100364089 cites W2066760606 @default.
- W3100364089 cites W2074792377 @default.
- W3100364089 cites W2077504951 @default.
- W3100364089 cites W2080651153 @default.
- W3100364089 cites W2082180868 @default.
- W3100364089 cites W2085222910 @default.
- W3100364089 cites W2090148868 @default.
- W3100364089 cites W2091395194 @default.
- W3100364089 cites W2091505318 @default.
- W3100364089 cites W2099632176 @default.
- W3100364089 cites W2101146511 @default.
- W3100364089 cites W2101861123 @default.
- W3100364089 cites W2105697752 @default.
- W3100364089 cites W2125164919 @default.
- W3100364089 cites W2143027421 @default.
- W3100364089 cites W2276782826 @default.
- W3100364089 cites W2398568518 @default.
- W3100364089 cites W2590651547 @default.
- W3100364089 cites W2626554108 @default.
- W3100364089 cites W2791524452 @default.
- W3100364089 cites W2807139341 @default.
- W3100364089 cites W2807234846 @default.
- W3100364089 cites W2896262697 @default.
- W3100364089 cites W2910288080 @default.
- W3100364089 cites W2986012156 @default.
- W3100364089 cites W2990461425 @default.
- W3100364089 cites W2999071198 @default.
- W3100364089 cites W3022502074 @default.
- W3100364089 doi "https://doi.org/10.1186/s13041-020-00686-2" @default.
- W3100364089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7664014" @default.
- W3100364089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33187547" @default.
- W3100364089 hasPublicationYear "2020" @default.
- W3100364089 type Work @default.
- W3100364089 sameAs 3100364089 @default.
- W3100364089 citedByCount "9" @default.
- W3100364089 countsByYear W31003640892021 @default.
- W3100364089 countsByYear W31003640892022 @default.
- W3100364089 countsByYear W31003640892023 @default.
- W3100364089 crossrefType "journal-article" @default.
- W3100364089 hasAuthorship W3100364089A5014807064 @default.
- W3100364089 hasAuthorship W3100364089A5022255280 @default.
- W3100364089 hasAuthorship W3100364089A5044912860 @default.
- W3100364089 hasAuthorship W3100364089A5052297688 @default.
- W3100364089 hasAuthorship W3100364089A5060418943 @default.
- W3100364089 hasAuthorship W3100364089A5073695220 @default.
- W3100364089 hasAuthorship W3100364089A5085832747 @default.
- W3100364089 hasAuthorship W3100364089A5086603848 @default.
- W3100364089 hasBestOaLocation W31003640891 @default.
- W3100364089 hasConcept C104317684 @default.
- W3100364089 hasConcept C127561419 @default.
- W3100364089 hasConcept C178790620 @default.
- W3100364089 hasConcept C185592680 @default.
- W3100364089 hasConcept C190283241 @default.
- W3100364089 hasConcept C2776151105 @default.
- W3100364089 hasConcept C2778560701 @default.
- W3100364089 hasConcept C48349386 @default.
- W3100364089 hasConcept C540031477 @default.
- W3100364089 hasConcept C55493867 @default.