Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100366281> ?p ?o ?g. }
- W3100366281 abstract "Abstract eIF2α phosphorylation-mediated translational regulation is crucial for global translation repression by various stresses, including the unfolded protein response (UPR). However, translational control during UPR has not been demonstrated in yeast. This study investigated ribosome ubiquitination-mediated translational controls during UPR. Tunicamycin-induced ER stress enhanced the levels of ubiquitination of the ribosomal proteins uS10, uS3 and eS7. Not4-mediated monoubiquitination of eS7A was required for resistance to tunicamycin, whereas E3 ligase Hel2-mediated ubiquitination of uS10 was not. Ribosome profiling showed that the monoubiquitination of eS7A was crucial for translational regulation, including the upregulation of the spliced form of HAC1 ( HAC1i ) mRNA and the downregulation of Histidine triad NucleoTide-binding 1 ( HNT1 ) mRNA. Downregulation of the deubiquitinating enzyme complex Upb3-Bre5 increased the levels of ubiquitinated eS7A during UPR in an Ire1-independent manner. These findings suggest that the monoubiquitination of ribosomal protein eS7A plays a crucial role in translational controls during the ER stress response in yeast." @default.
- W3100366281 created "2020-11-23" @default.
- W3100366281 creator A5005744006 @default.
- W3100366281 creator A5013768648 @default.
- W3100366281 creator A5014737668 @default.
- W3100366281 creator A5015429318 @default.
- W3100366281 creator A5016282453 @default.
- W3100366281 creator A5018866207 @default.
- W3100366281 creator A5025748633 @default.
- W3100366281 creator A5030338003 @default.
- W3100366281 creator A5036640655 @default.
- W3100366281 creator A5061533640 @default.
- W3100366281 creator A5064957769 @default.
- W3100366281 creator A5072883823 @default.
- W3100366281 date "2020-11-12" @default.
- W3100366281 modified "2023-10-16" @default.
- W3100366281 title "Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome" @default.
- W3100366281 cites W1517086909 @default.
- W3100366281 cites W1705731262 @default.
- W3100366281 cites W1966072209 @default.
- W3100366281 cites W1968002307 @default.
- W3100366281 cites W1970090817 @default.
- W3100366281 cites W1980271811 @default.
- W3100366281 cites W1982193860 @default.
- W3100366281 cites W1986290768 @default.
- W3100366281 cites W1989768108 @default.
- W3100366281 cites W1990136127 @default.
- W3100366281 cites W1990400035 @default.
- W3100366281 cites W1993697882 @default.
- W3100366281 cites W2000789682 @default.
- W3100366281 cites W2010691148 @default.
- W3100366281 cites W2031291041 @default.
- W3100366281 cites W2036379661 @default.
- W3100366281 cites W2037786814 @default.
- W3100366281 cites W2048086508 @default.
- W3100366281 cites W2078212551 @default.
- W3100366281 cites W2083445344 @default.
- W3100366281 cites W2091544975 @default.
- W3100366281 cites W2096697497 @default.
- W3100366281 cites W2103334789 @default.
- W3100366281 cites W2106983618 @default.
- W3100366281 cites W2120736516 @default.
- W3100366281 cites W2127848114 @default.
- W3100366281 cites W2137755719 @default.
- W3100366281 cites W2140717971 @default.
- W3100366281 cites W2152239989 @default.
- W3100366281 cites W2153074213 @default.
- W3100366281 cites W2154046032 @default.
- W3100366281 cites W2155552623 @default.
- W3100366281 cites W2157495054 @default.
- W3100366281 cites W2168092724 @default.
- W3100366281 cites W2540126827 @default.
- W3100366281 cites W2544234056 @default.
- W3100366281 cites W2568866823 @default.
- W3100366281 cites W2580905939 @default.
- W3100366281 cites W2582200059 @default.
- W3100366281 cites W2589978322 @default.
- W3100366281 cites W2621281388 @default.
- W3100366281 cites W2730564452 @default.
- W3100366281 cites W2738059873 @default.
- W3100366281 cites W2775215876 @default.
- W3100366281 cites W2883606517 @default.
- W3100366281 cites W2895153371 @default.
- W3100366281 cites W2903508759 @default.
- W3100366281 cites W2908095537 @default.
- W3100366281 cites W2922547250 @default.
- W3100366281 cites W3029236991 @default.
- W3100366281 doi "https://doi.org/10.1038/s41598-020-76239-3" @default.
- W3100366281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7661504" @default.
- W3100366281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33184379" @default.
- W3100366281 hasPublicationYear "2020" @default.
- W3100366281 type Work @default.
- W3100366281 sameAs 3100366281 @default.
- W3100366281 citedByCount "16" @default.
- W3100366281 countsByYear W31003662812021 @default.
- W3100366281 countsByYear W31003662812022 @default.
- W3100366281 countsByYear W31003662812023 @default.
- W3100366281 crossrefType "journal-article" @default.
- W3100366281 hasAuthorship W3100366281A5005744006 @default.
- W3100366281 hasAuthorship W3100366281A5013768648 @default.
- W3100366281 hasAuthorship W3100366281A5014737668 @default.
- W3100366281 hasAuthorship W3100366281A5015429318 @default.
- W3100366281 hasAuthorship W3100366281A5016282453 @default.
- W3100366281 hasAuthorship W3100366281A5018866207 @default.
- W3100366281 hasAuthorship W3100366281A5025748633 @default.
- W3100366281 hasAuthorship W3100366281A5030338003 @default.
- W3100366281 hasAuthorship W3100366281A5036640655 @default.
- W3100366281 hasAuthorship W3100366281A5061533640 @default.
- W3100366281 hasAuthorship W3100366281A5064957769 @default.
- W3100366281 hasAuthorship W3100366281A5072883823 @default.
- W3100366281 hasBestOaLocation W31003662811 @default.
- W3100366281 hasConcept C104317684 @default.
- W3100366281 hasConcept C105580179 @default.
- W3100366281 hasConcept C127561419 @default.
- W3100366281 hasConcept C134459356 @default.
- W3100366281 hasConcept C139447449 @default.
- W3100366281 hasConcept C149364088 @default.
- W3100366281 hasConcept C153911025 @default.
- W3100366281 hasConcept C158617107 @default.
- W3100366281 hasConcept C182325514 @default.