FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100366352> ?p ?o ?g. }

• W3100366352 abstract "Our understanding of genetic mechanisms driving early embryonic development is primarily based on experiments conducted on mice, however translation of findings can be limited by physiological differences between mice and humans. To address this, we investigated whether the spiny mouse ( Acomys cahirinus ) is a closer model of early human embryonic development due to their more human-like endocrine profile. We therefore characterised the initiation of gene transcription in the spiny mouse embryo and compared the pattern of gene expression during the embryonic genome activation (EGA) with common mouse and human embryos. Naturally-mated spiny mouse embryos were obtained at the 2-cell, 4-cell and 8-cell stages of development (n=4 biological replicates per stage). RNA-Seq of these samples produced 709.1M paired-end reads in total. De novo assembly of reads was conducted using Trinity. Embryo-specific transcripts were extracted from the de novo assembly and added to the reference spiny mouse transcriptome. Transcription was first detected between the 2-cell and 4-cell stages for the majority of genes (n=3,428), with fewer genes first transcribed between the 4-cell and 8-cell stages (n=1,150). The pattern of gene expression in spiny mouse embryos during this period of development is more human-like than common mouse embryos. This is the first evidence the spiny mouse may provide a more suitable model of human embryonic development. The improved reference Acomys cahirinus transcriptome is publically accessible, further increasing the value of this tool for ongoing research. Further investigation into early development in the spiny mouse is warranted." @default.
• W3100366352 created "2020-11-23" @default.
• W3100366352 creator A5026576520 @default.
• W3100366352 creator A5050479075 @default.
• W3100366352 creator A5054517578 @default.
• W3100366352 creator A5079238845 @default.
• W3100366352 date "2018-03-12" @default.
• W3100366352 modified "2023-09-23" @default.
• W3100366352 title "Embryonic gene transcription in the spiny mouse (<i>Acomys cahirinus</i>): an investigtion into the embryonic genome activation" @default.
• W3100366352 cites W1205396264 @default.
• W3100366352 cites W1536601791 @default.
• W3100366352 cites W1544206819 @default.
• W3100366352 cites W1580854767 @default.
• W3100366352 cites W1970857759 @default.
• W3100366352 cites W1972377244 @default.
• W3100366352 cites W1980424546 @default.
• W3100366352 cites W1990498979 @default.
• W3100366352 cites W1991845838 @default.
• W3100366352 cites W1998496693 @default.
• W3100366352 cites W2002982523 @default.
• W3100366352 cites W2007439698 @default.
• W3100366352 cites W2011657487 @default.
• W3100366352 cites W2021262032 @default.
• W3100366352 cites W2028630156 @default.
• W3100366352 cites W2031221239 @default.
• W3100366352 cites W2039483600 @default.
• W3100366352 cites W2040235353 @default.
• W3100366352 cites W2041784602 @default.
• W3100366352 cites W2045204781 @default.
• W3100366352 cites W2047784091 @default.
• W3100366352 cites W2056397474 @default.
• W3100366352 cites W2063337177 @default.
• W3100366352 cites W2068227428 @default.
• W3100366352 cites W2075511135 @default.
• W3100366352 cites W2084793610 @default.
• W3100366352 cites W2086277161 @default.
• W3100366352 cites W2090935343 @default.
• W3100366352 cites W2104052851 @default.
• W3100366352 cites W2107018762 @default.
• W3100366352 cites W2108234281 @default.
• W3100366352 cites W2108445577 @default.
• W3100366352 cites W2108567637 @default.
• W3100366352 cites W2114104545 @default.
• W3100366352 cites W2130116522 @default.
• W3100366352 cites W2131271579 @default.
• W3100366352 cites W2133237718 @default.
• W3100366352 cites W2146767125 @default.
• W3100366352 cites W2146984594 @default.
• W3100366352 cites W2157524927 @default.
• W3100366352 cites W2158714788 @default.
• W3100366352 cites W2159066033 @default.
• W3100366352 cites W2164359007 @default.
• W3100366352 cites W2164883482 @default.
• W3100366352 cites W2169278987 @default.
• W3100366352 cites W2170551349 @default.
• W3100366352 cites W2171199014 @default.
• W3100366352 cites W2171291396 @default.
• W3100366352 cites W2182005855 @default.
• W3100366352 cites W2223836536 @default.
• W3100366352 cites W2299074704 @default.
• W3100366352 cites W2338259409 @default.
• W3100366352 cites W2345160986 @default.
• W3100366352 cites W2432815617 @default.
• W3100366352 cites W2465681871 @default.
• W3100366352 cites W2556072506 @default.
• W3100366352 cites W2563535135 @default.
• W3100366352 cites W2571745526 @default.
• W3100366352 cites W2578505993 @default.
• W3100366352 cites W2591197791 @default.
• W3100366352 cites W2615328847 @default.
• W3100366352 cites W2624605702 @default.
• W3100366352 cites W2625650362 @default.
• W3100366352 cites W2626267370 @default.
• W3100366352 cites W2746098516 @default.
• W3100366352 cites W2753775066 @default.
• W3100366352 cites W2950869193 @default.
• W3100366352 doi "https://doi.org/10.1101/280412" @default.
• W3100366352 hasPublicationYear "2018" @default.
• W3100366352 type Work @default.
• W3100366352 sameAs 3100366352 @default.
• W3100366352 citedByCount "3" @default.
• W3100366352 countsByYear W31003663522020 @default.
• W3100366352 countsByYear W31003663522022 @default.
• W3100366352 crossrefType "posted-content" @default.
• W3100366352 hasAuthorship W3100366352A5026576520 @default.
• W3100366352 hasAuthorship W3100366352A5050479075 @default.
• W3100366352 hasAuthorship W3100366352A5054517578 @default.
• W3100366352 hasAuthorship W3100366352A5079238845 @default.
• W3100366352 hasBestOaLocation W31003663521 @default.
• W3100366352 hasConcept C104317684 @default.
• W3100366352 hasConcept C138885662 @default.
• W3100366352 hasConcept C141231307 @default.
• W3100366352 hasConcept C145103041 @default.
• W3100366352 hasConcept C150194340 @default.
• W3100366352 hasConcept C162317418 @default.
• W3100366352 hasConcept C17341445 @default.
• W3100366352 hasConcept C179926584 @default.
• W3100366352 hasConcept C196843134 @default.
• W3100366352 hasConcept C28748434 @default.
• W3100366352 hasConcept C41895202 @default.

• next