Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100370387> ?p ?o ?g. }
- W3100370387 abstract "E1 and E2 (E1E2), the entry proteins of Hepatitis C Virus (HCV), are unlike that of any other virus yet described, and the detailed molecular mechanisms of HCV entry/fusion remain unknown. Hypervariable region-1 (HVR-1) of E2 is a putative intrinsically disordered protein tail. Here, we demonstrate that HVR-1 has an autoinhibitory function that suppresses the activity of E1E2 on free virions; this is dependent on its conformational entropy. Crucially, to allow entry, this mechanism is turned off by host receptor interactions at the cell surface. Thus, HVR-1 is akin to a safety catch on E1E2 activity. Mutations that reduce conformational entropy in HVR-1, or genetic deletion of HVR-1, turn off the safety catch to generate hyper-reactive HCV that exhibits enhanced virus entry but is thermally unstable and acutely sensitive to neutralising antibodies. Therefore, the HVR-1 safety catch controls the efficiency of virus entry and maintains resistance to neutralising antibodies." @default.
- W3100370387 created "2020-11-23" @default.
- W3100370387 creator A5001972889 @default.
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- W3100370387 date "2020-11-11" @default.
- W3100370387 modified "2023-09-26" @default.
- W3100370387 title "An Entropic Safety Catch Controls Hepatitis C Virus Entry and Antibody Resistance" @default.
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