FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100376592> ?p ?o ?g. }

• W3100376592 abstract "Transport of colloid particles through narrow channels is ubiquitous in cell biology as well as becoming increasingly important for microfluidic applications or targeted drug delivery. Membrane channels in cells are useful models for artificial designs because of their high efficiency, selectivity, and robustness to external fluctuations. Here, we model the passive channels that let cargo simply diffuse through them, affected by a potential profile along the way. Passive transporters achieve high levels of efficiency and specificity from binding interactions with the cargo inside the channel. This however leads to a paradox: why should channels which are so narrow that they are blocked by their cargo evolve to have binding regions for their cargo if that will effectively block them? Using Brownian dynamics simulations, we show that different potentials, notably symmetric, increase the flux through narrow passive channels – and investigate how shape and depth of potentials influence the flux. We find that there exist optimal depths for certain potential shapes and that it is most efficient to apply a small force over an extended region of the channel. On the other hand, having several spatially discrete binding pockets will not alter the flux significantly. We also explore the role of many-particle effects arising from pairwise particle interactions with their neighbours and demonstrate that the relative changes in flux can be accounted for by the kinetics of the absorption reaction at the end of the channel." @default.
• W3100376592 created "2020-11-23" @default.
• W3100376592 creator A5057039281 @default.
• W3100376592 creator A5088132879 @default.
• W3100376592 date "2014-12-09" @default.
• W3100376592 modified "2023-09-27" @default.
• W3100376592 title "Role of the potential landscape on the single-file diffusion through channels" @default.
• W3100376592 cites W1755259150 @default.
• W3100376592 cites W1967160844 @default.
• W3100376592 cites W1969479499 @default.
• W3100376592 cites W1969555676 @default.
• W3100376592 cites W1972074942 @default.
• W3100376592 cites W1978514520 @default.
• W3100376592 cites W1984717522 @default.
• W3100376592 cites W1991041048 @default.
• W3100376592 cites W1992595792 @default.
• W3100376592 cites W1995204686 @default.
• W3100376592 cites W1997230748 @default.
• W3100376592 cites W2007898019 @default.
• W3100376592 cites W2017957151 @default.
• W3100376592 cites W2019465613 @default.
• W3100376592 cites W2029672283 @default.
• W3100376592 cites W2031323040 @default.
• W3100376592 cites W2031576029 @default.
• W3100376592 cites W2033813683 @default.
• W3100376592 cites W2048263330 @default.
• W3100376592 cites W2049959402 @default.
• W3100376592 cites W2079228930 @default.
• W3100376592 cites W2079685391 @default.
• W3100376592 cites W2082267050 @default.
• W3100376592 cites W2084405546 @default.
• W3100376592 cites W2091467493 @default.
• W3100376592 cites W2131067557 @default.
• W3100376592 cites W2132168998 @default.
• W3100376592 cites W2141841057 @default.
• W3100376592 cites W2273121504 @default.
• W3100376592 cites W3100086548 @default.
• W3100376592 doi "https://doi.org/10.1063/1.4903175" @default.
• W3100376592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25494767" @default.
• W3100376592 hasPublicationYear "2014" @default.
• W3100376592 type Work @default.
• W3100376592 sameAs 3100376592 @default.
• W3100376592 citedByCount "5" @default.
• W3100376592 countsByYear W31003765922017 @default.
• W3100376592 countsByYear W31003765922019 @default.
• W3100376592 countsByYear W31003765922020 @default.
• W3100376592 countsByYear W31003765922021 @default.
• W3100376592 countsByYear W31003765922022 @default.
• W3100376592 crossrefType "journal-article" @default.
• W3100376592 hasAuthorship W3100376592A5057039281 @default.
• W3100376592 hasAuthorship W3100376592A5088132879 @default.
• W3100376592 hasBestOaLocation W31003765922 @default.
• W3100376592 hasConcept C104317684 @default.
• W3100376592 hasConcept C112401455 @default.
• W3100376592 hasConcept C121332964 @default.
• W3100376592 hasConcept C121864883 @default.
• W3100376592 hasConcept C12554922 @default.
• W3100376592 hasConcept C127162648 @default.
• W3100376592 hasConcept C130603088 @default.
• W3100376592 hasConcept C159467904 @default.
• W3100376592 hasConcept C171250308 @default.
• W3100376592 hasConcept C178790620 @default.
• W3100376592 hasConcept C185592680 @default.
• W3100376592 hasConcept C186060115 @default.
• W3100376592 hasConcept C192562407 @default.
• W3100376592 hasConcept C41008148 @default.
• W3100376592 hasConcept C55493867 @default.
• W3100376592 hasConcept C62520636 @default.
• W3100376592 hasConcept C63479239 @default.
• W3100376592 hasConcept C68709404 @default.
• W3100376592 hasConcept C69357855 @default.
• W3100376592 hasConcept C76155785 @default.
• W3100376592 hasConcept C8673954 @default.
• W3100376592 hasConcept C86803240 @default.
• W3100376592 hasConcept C97355855 @default.
• W3100376592 hasConceptScore W3100376592C104317684 @default.
• W3100376592 hasConceptScore W3100376592C112401455 @default.
• W3100376592 hasConceptScore W3100376592C121332964 @default.
• W3100376592 hasConceptScore W3100376592C121864883 @default.
• W3100376592 hasConceptScore W3100376592C12554922 @default.
• W3100376592 hasConceptScore W3100376592C127162648 @default.
• W3100376592 hasConceptScore W3100376592C130603088 @default.
• W3100376592 hasConceptScore W3100376592C159467904 @default.
• W3100376592 hasConceptScore W3100376592C171250308 @default.
• W3100376592 hasConceptScore W3100376592C178790620 @default.
• W3100376592 hasConceptScore W3100376592C185592680 @default.
• W3100376592 hasConceptScore W3100376592C186060115 @default.
• W3100376592 hasConceptScore W3100376592C192562407 @default.
• W3100376592 hasConceptScore W3100376592C41008148 @default.
• W3100376592 hasConceptScore W3100376592C55493867 @default.
• W3100376592 hasConceptScore W3100376592C62520636 @default.
• W3100376592 hasConceptScore W3100376592C63479239 @default.
• W3100376592 hasConceptScore W3100376592C68709404 @default.
• W3100376592 hasConceptScore W3100376592C69357855 @default.
• W3100376592 hasConceptScore W3100376592C76155785 @default.
• W3100376592 hasConceptScore W3100376592C8673954 @default.
• W3100376592 hasConceptScore W3100376592C86803240 @default.
• W3100376592 hasConceptScore W3100376592C97355855 @default.
• W3100376592 hasIssue "22" @default.
• W3100376592 hasLocation W31003765921 @default.

• next