Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100377366> ?p ?o ?g. }
- W3100377366 abstract "Summary Synaptic diversity is a key feature of neural circuits. The structural and functional diversity of closely spaced inputs converging on the same neuron suggests that cell-surface interactions are essential in organizing input properties. Here, we analyzed the cell-surface protein (CSP) composition of hippocampal mossy fiber (MF) inputs on CA3 pyramidal neurons to identify regulators of MF-CA3 synapse properties. We uncover a rich cell-surface repertoire that includes adhesion proteins, guidance cue receptors, extracellular matrix (ECM) proteins, and uncharacterized CSPs. Interactome screening reveals multiple ligand-receptor modules and identifies ECM protein Tenascin-R (TenR) as a ligand of the uncharacterized neuronal receptor IgSF8. Presynaptic Igsf8 deletion impairs MF-CA3 synaptic architecture and robustly decreases the density of bouton filopodia that provide feedforward inhibition of CA3 neurons. Consequently, loss of IgSF8 increases CA3 neuron excitability. Our findings identify IgSF8 as a regulator of CA3 microcircuit development and suggest that combinations of CSP modules define input identity." @default.
- W3100377366 created "2020-11-23" @default.
- W3100377366 creator A5007195843 @default.
- W3100377366 creator A5022967767 @default.
- W3100377366 creator A5023697901 @default.
- W3100377366 creator A5026312702 @default.
- W3100377366 creator A5035691434 @default.
- W3100377366 creator A5043338272 @default.
- W3100377366 creator A5043904534 @default.
- W3100377366 creator A5049350479 @default.
- W3100377366 creator A5053093737 @default.
- W3100377366 creator A5058257370 @default.
- W3100377366 creator A5058308160 @default.
- W3100377366 creator A5064584062 @default.
- W3100377366 creator A5074891349 @default.
- W3100377366 creator A5089865373 @default.
- W3100377366 date "2019-11-18" @default.
- W3100377366 modified "2023-09-30" @default.
- W3100377366 title "Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer" @default.
- W3100377366 cites W1554753026 @default.
- W3100377366 cites W1600525795 @default.
- W3100377366 cites W1670369629 @default.
- W3100377366 cites W1850233136 @default.
- W3100377366 cites W1961476520 @default.
- W3100377366 cites W1965831612 @default.
- W3100377366 cites W1966776414 @default.
- W3100377366 cites W1967324141 @default.
- W3100377366 cites W1967963204 @default.
- W3100377366 cites W1969650326 @default.
- W3100377366 cites W1969878270 @default.
- W3100377366 cites W1976750232 @default.
- W3100377366 cites W1976786580 @default.
- W3100377366 cites W1979586234 @default.
- W3100377366 cites W1979763911 @default.
- W3100377366 cites W1983555571 @default.
- W3100377366 cites W1984875318 @default.
- W3100377366 cites W1990299806 @default.
- W3100377366 cites W1995852110 @default.
- W3100377366 cites W1996405595 @default.
- W3100377366 cites W1997218140 @default.
- W3100377366 cites W2005352118 @default.
- W3100377366 cites W2008760033 @default.
- W3100377366 cites W2012448906 @default.
- W3100377366 cites W2014379663 @default.
- W3100377366 cites W2016441660 @default.
- W3100377366 cites W2018930713 @default.
- W3100377366 cites W2019173591 @default.
- W3100377366 cites W2023556856 @default.
- W3100377366 cites W2024015768 @default.
- W3100377366 cites W2026465178 @default.
- W3100377366 cites W2026717174 @default.
- W3100377366 cites W2026917639 @default.
- W3100377366 cites W2028474009 @default.
- W3100377366 cites W2033470434 @default.
- W3100377366 cites W2041971833 @default.
- W3100377366 cites W2042397395 @default.
- W3100377366 cites W2042984003 @default.
- W3100377366 cites W2047394367 @default.
- W3100377366 cites W2048361100 @default.
- W3100377366 cites W2050032667 @default.
- W3100377366 cites W2050566021 @default.
- W3100377366 cites W2053115172 @default.
- W3100377366 cites W2053894359 @default.
- W3100377366 cites W2055775269 @default.
- W3100377366 cites W2062744640 @default.
- W3100377366 cites W2063298068 @default.
- W3100377366 cites W2064532472 @default.
- W3100377366 cites W2069186913 @default.
- W3100377366 cites W2069597067 @default.
- W3100377366 cites W2070372183 @default.
- W3100377366 cites W2070661052 @default.
- W3100377366 cites W2081608180 @default.
- W3100377366 cites W2100591877 @default.
- W3100377366 cites W2122955107 @default.
- W3100377366 cites W2123848124 @default.
- W3100377366 cites W2125095601 @default.
- W3100377366 cites W2129972752 @default.
- W3100377366 cites W2140262688 @default.
- W3100377366 cites W2142686469 @default.
- W3100377366 cites W2143454033 @default.
- W3100377366 cites W2152438166 @default.
- W3100377366 cites W2153124044 @default.
- W3100377366 cites W2155870242 @default.
- W3100377366 cites W2157140132 @default.
- W3100377366 cites W2158166672 @default.
- W3100377366 cites W2161176515 @default.
- W3100377366 cites W2167279371 @default.
- W3100377366 cites W2169063473 @default.
- W3100377366 cites W2169423035 @default.
- W3100377366 cites W2170893097 @default.
- W3100377366 cites W2182963873 @default.
- W3100377366 cites W2185034389 @default.
- W3100377366 cites W2191037482 @default.
- W3100377366 cites W2265732655 @default.
- W3100377366 cites W2343439038 @default.
- W3100377366 cites W2344649716 @default.
- W3100377366 cites W2414948043 @default.
- W3100377366 cites W2465176360 @default.
- W3100377366 cites W2469527727 @default.
- W3100377366 cites W2470853836 @default.