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- W3100389481 abstract "Summary Many germ cells (GCs) are eliminated during development, long before differentiating to egg or sperm, but it is not clear why. Here, we examined how GC composition in the mouse fetal testis is altered by scheduled apoptosis during sex differentiation. Multicolored-lineage tracing revealed that apoptosis affects clonally-related GCs, suggesting that this fate decision occurs autonomously based on shared intrinsic properties. We identified extensive transcriptional heterogeneity among fetal GCs including an apoptosis-susceptible subpopulation delineated by high Trp53 and deviant differentiation. Alternatively, the GC subpopulation most likely to survive was advanced in differentiation. These results indicate that GC developmental fate is based upon discrete and cell-heritable fitnesses and imply that a dichotomy between sex-differentiation and apoptosis coordinates the removal of developmentally incompetent cells to improve gamete quality. Evidence that GC subpopulations are in different epigenetic states suggests that errors in epigenetic reprogramming form the basis of aberrant differentiation and apoptotic selection. One sentence summary Germ cells undergo autonomous selection in the fetal testis to promote male differentiation" @default.
- W3100389481 created "2020-11-23" @default.
- W3100389481 creator A5043899656 @default.
- W3100389481 creator A5080751444 @default.
- W3100389481 date "2019-04-05" @default.
- W3100389481 modified "2023-10-17" @default.
- W3100389481 title "Apoptosis in the fetal testis eliminates developmentally defective germ cell clones" @default.
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- W3100389481 doi "https://doi.org/10.1101/601013" @default.
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