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- W3100391307 startingPage "3319" @default.
- W3100391307 abstract "Mutations in mismatch repair genes leading to mismatch repair (MMR) deficiency (dMMR) and microsatellite instability (MSI) have been implicated in multiple types of gynecologic malignancies. Endometrial carcinoma represents the largest group, with approximately 30% of these cancers caused by dMMR/MSI. Thus, testing for dMMR is now routine for endometrial cancer. Somatic mutations leading to dMMR account for approximately 90% of these cancers. However, in 5–10% of cases, MMR protein deficiency is due to a germline mutation in the mismatch repair genes MLH1, MSH2, MSH6, PMS2, or EPCAM. These germline mutations, known as Lynch syndrome, are associated with an increased risk of both endometrial and ovarian cancer, in addition to colorectal, gastric, urinary tract, and brain malignancies. So far, gynecological cancers with dMMR/MSI are not well characterized and markers for detection of MSI in gynecological cancers are not well defined. In addition, currently advanced endometrial cancers have a poor prognosis and are treated without regard to MSI status. Elucidation of the mechanism causing dMMR/MSI gynecological cancers would aid in diagnosis and therapeutic intervention. Recently, a new immunotherapy was approved for the treatment of solid tumors with MSI that have recurred or progressed after failing traditional treatment strategies. In this review, we summarize the MMR defects and MSI observed in gynecological cancers, their prognostic value, and advances in therapeutic strategies to treat these cancers." @default.
- W3100391307 created "2020-11-23" @default.
- W3100391307 creator A5007649659 @default.
- W3100391307 creator A5007724400 @default.
- W3100391307 creator A5036543946 @default.
- W3100391307 creator A5050775432 @default.
- W3100391307 date "2020-11-10" @default.
- W3100391307 modified "2023-10-05" @default.
- W3100391307 title "Gynecological Cancers Caused by Deficient Mismatch Repair and Microsatellite Instability" @default.
- W3100391307 cites W1493791851 @default.
- W3100391307 cites W1504535992 @default.
- W3100391307 cites W1506338733 @default.
- W3100391307 cites W1651950734 @default.
- W3100391307 cites W1663153674 @default.
- W3100391307 cites W1718266024 @default.
- W3100391307 cites W1893792948 @default.
- W3100391307 cites W1926715094 @default.
- W3100391307 cites W1963877113 @default.
- W3100391307 cites W1964858952 @default.
- W3100391307 cites W1968357712 @default.
- W3100391307 cites W1970499787 @default.
- W3100391307 cites W1972254989 @default.
- W3100391307 cites W1973244269 @default.
- W3100391307 cites W1974631966 @default.
- W3100391307 cites W1974737241 @default.
- W3100391307 cites W1975800190 @default.
- W3100391307 cites W1980480427 @default.
- W3100391307 cites W1981355745 @default.
- W3100391307 cites W1984642649 @default.
- W3100391307 cites W1984963774 @default.
- W3100391307 cites W1987246047 @default.
- W3100391307 cites W1989950905 @default.
- W3100391307 cites W1993051520 @default.
- W3100391307 cites W1998655295 @default.
- W3100391307 cites W2007788356 @default.
- W3100391307 cites W2011367808 @default.
- W3100391307 cites W2012331065 @default.
- W3100391307 cites W2013321862 @default.
- W3100391307 cites W2017237069 @default.
- W3100391307 cites W2025366879 @default.
- W3100391307 cites W2026035097 @default.
- W3100391307 cites W2029499348 @default.
- W3100391307 cites W2032348811 @default.
- W3100391307 cites W2032613104 @default.
- W3100391307 cites W2035685670 @default.
- W3100391307 cites W2037606715 @default.
- W3100391307 cites W2039164450 @default.
- W3100391307 cites W2041086704 @default.
- W3100391307 cites W2041440766 @default.
- W3100391307 cites W2042160009 @default.
- W3100391307 cites W2044088718 @default.
- W3100391307 cites W2044142706 @default.
- W3100391307 cites W2047067156 @default.
- W3100391307 cites W2051052655 @default.
- W3100391307 cites W2065635506 @default.
- W3100391307 cites W2067210754 @default.
- W3100391307 cites W2073549025 @default.
- W3100391307 cites W2074295060 @default.
- W3100391307 cites W2077059059 @default.
- W3100391307 cites W2077640472 @default.
- W3100391307 cites W2078391975 @default.
- W3100391307 cites W2081560420 @default.
- W3100391307 cites W2082255272 @default.
- W3100391307 cites W2092513068 @default.
- W3100391307 cites W2094792254 @default.
- W3100391307 cites W2094884044 @default.
- W3100391307 cites W2096731080 @default.
- W3100391307 cites W2098074852 @default.
- W3100391307 cites W2101653483 @default.
- W3100391307 cites W2101810235 @default.
- W3100391307 cites W2102767793 @default.
- W3100391307 cites W2113194569 @default.
- W3100391307 cites W2113215973 @default.
- W3100391307 cites W2115237139 @default.
- W3100391307 cites W2115258708 @default.
- W3100391307 cites W2115292353 @default.
- W3100391307 cites W2115606719 @default.
- W3100391307 cites W2119360625 @default.
- W3100391307 cites W2121123497 @default.
- W3100391307 cites W2121968591 @default.
- W3100391307 cites W2123017921 @default.
- W3100391307 cites W2123305974 @default.
- W3100391307 cites W2123709855 @default.
- W3100391307 cites W2126273255 @default.
- W3100391307 cites W2128793721 @default.
- W3100391307 cites W2131173813 @default.
- W3100391307 cites W2131346206 @default.
- W3100391307 cites W2132173772 @default.
- W3100391307 cites W2132604268 @default.
- W3100391307 cites W2134179374 @default.
- W3100391307 cites W2134846672 @default.
- W3100391307 cites W2135810600 @default.
- W3100391307 cites W2139015332 @default.
- W3100391307 cites W2139353300 @default.
- W3100391307 cites W2143895061 @default.
- W3100391307 cites W2147925506 @default.
- W3100391307 cites W2151472138 @default.
- W3100391307 cites W2153217893 @default.