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- W3100402633 abstract "Abstract The prokaryotic chemotaxis system is arguably the best-understood signaling pathway in biology. In all previously described species, chemoreceptors organize into a hexagonal (P6 symmetry) extended array. Here, we report an alternative symmetry (P2) of the chemotaxis apparatus that emerges from a strict linear organization of the histidine kinase CheA in Treponema denticola cells, which possesses arrays with the highest native curvature investigated thus far. Using cryo-ET, we reveal that Td chemoreceptor arrays assume an unusual arrangement of the supra-molecular protein assembly that has likely evolved to accommodate the high membrane curvature. The arrays have several atypical features, such as an extended dimerization domain of CheA and a variant CheW-CheR-like fusion protein that is critical for maintaining an ordered chemosensory apparatus. Furthermore, the previously characterized Td oxygen sensor ODP influences CheA ordering. These results suggest a greater diversity of the chemotaxis signaling system than previously thought." @default.
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- W3100402633 date "2020-11-13" @default.
- W3100402633 modified "2023-10-01" @default.
- W3100402633 title "Atypical chemoreceptor arrays accommodate high membrane curvature" @default.
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- W3100402633 doi "https://doi.org/10.1038/s41467-020-19628-6" @default.
- W3100402633 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7666581" @default.
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