Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100417091> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3100417091 abstract "Objectives Investigate the importance of a set of easy accessible biomarkers besides lymphnode(LN) status within the ESMO risk stratification for optimizing adjuvant treatment in endometrial cancer. Methods Within the European Network for Individualized Treatment of Endometrial Cancer (ENITEC), a retrospective multicenter cohort study was performed with a median follow-up of 5.5-years. Immunohistochemical analysis of tumor protein 53(p53), estrogen receptor(ER), progesterone receptor(PR) and L1 cell-adhesion molecule(L1CAM) expression were analyzed on pre-operative specimens. Biomarker expression was related to LN status, defined as positive(N1), negative(N0) or unknown(Nx). Correlations and Cox regression analysis were performed. Results A total of 763 EC patients were included. Lymphadenectomy was performed in 493(64.6%) patients of whom 53(6.9%) had N1. Adjuvant treatment was applied in 347(46.5%) patients. Abnormal p53(p53-abn) expression was observed in 14.7%, L1CAM expression in 10.4%, loss of ER in 10.0%, and loss of PR in 18.1%. Significant reduced disease specific survival(DSS) and/or recurrence free survival(RFS) was observed within patients with N1 and 53-abn, L1CAM positive expression, or loss of ER/PR. N1 and normal biomarkers show the same prognosis as patients with N0 or Nx, and abnormal biomarkers. In the multivariate Cox regression analysis loss of ER/PR and p53-abn were in addition to the ESMO classification ‘high-intermediate and high’ significantly associated with decreased DSS (HR 2.47[CI 1.20–5.07]p=0.013, HR 2.13[CI 1.02–4.41]p=0.043, HR 3.93[CI 1.98–7.81]p Conclusions We have shown that abnormal biomarker expression in addition to N1 or N0, is highly relevant in survival analysis and could potentially complement the ESMO risk stratification and therefore optimize adjuvant treatment." @default.
- W3100417091 created "2020-11-23" @default.
- W3100417091 creator A5010254927 @default.
- W3100417091 creator A5010836364 @default.
- W3100417091 creator A5028608453 @default.
- W3100417091 creator A5034308086 @default.
- W3100417091 creator A5045042294 @default.
- W3100417091 creator A5061676684 @default.
- W3100417091 creator A5064807039 @default.
- W3100417091 creator A5064832407 @default.
- W3100417091 creator A5066547884 @default.
- W3100417091 creator A5080083223 @default.
- W3100417091 creator A5083376344 @default.
- W3100417091 date "2020-11-01" @default.
- W3100417091 modified "2023-09-23" @default.
- W3100417091 title "295 The importance of biomarker expression in addition to lymph node status in the ESMO risk stratification of endometrial cancer" @default.
- W3100417091 doi "https://doi.org/10.1136/ijgc-2020-igcs.254" @default.
- W3100417091 hasPublicationYear "2020" @default.
- W3100417091 type Work @default.
- W3100417091 sameAs 3100417091 @default.
- W3100417091 citedByCount "0" @default.
- W3100417091 crossrefType "proceedings-article" @default.
- W3100417091 hasAuthorship W3100417091A5010254927 @default.
- W3100417091 hasAuthorship W3100417091A5010836364 @default.
- W3100417091 hasAuthorship W3100417091A5028608453 @default.
- W3100417091 hasAuthorship W3100417091A5034308086 @default.
- W3100417091 hasAuthorship W3100417091A5045042294 @default.
- W3100417091 hasAuthorship W3100417091A5061676684 @default.
- W3100417091 hasAuthorship W3100417091A5064807039 @default.
- W3100417091 hasAuthorship W3100417091A5064832407 @default.
- W3100417091 hasAuthorship W3100417091A5066547884 @default.
- W3100417091 hasAuthorship W3100417091A5080083223 @default.
- W3100417091 hasAuthorship W3100417091A5083376344 @default.
- W3100417091 hasBestOaLocation W31004170911 @default.
- W3100417091 hasConcept C121608353 @default.
- W3100417091 hasConcept C126322002 @default.
- W3100417091 hasConcept C143998085 @default.
- W3100417091 hasConcept C167135981 @default.
- W3100417091 hasConcept C185592680 @default.
- W3100417091 hasConcept C204232928 @default.
- W3100417091 hasConcept C2777088508 @default.
- W3100417091 hasConcept C2777863537 @default.
- W3100417091 hasConcept C2780824555 @default.
- W3100417091 hasConcept C2780849966 @default.
- W3100417091 hasConcept C2781197716 @default.
- W3100417091 hasConcept C50382708 @default.
- W3100417091 hasConcept C55493867 @default.
- W3100417091 hasConcept C71924100 @default.
- W3100417091 hasConcept C72563966 @default.
- W3100417091 hasConceptScore W3100417091C121608353 @default.
- W3100417091 hasConceptScore W3100417091C126322002 @default.
- W3100417091 hasConceptScore W3100417091C143998085 @default.
- W3100417091 hasConceptScore W3100417091C167135981 @default.
- W3100417091 hasConceptScore W3100417091C185592680 @default.
- W3100417091 hasConceptScore W3100417091C204232928 @default.
- W3100417091 hasConceptScore W3100417091C2777088508 @default.
- W3100417091 hasConceptScore W3100417091C2777863537 @default.
- W3100417091 hasConceptScore W3100417091C2780824555 @default.
- W3100417091 hasConceptScore W3100417091C2780849966 @default.
- W3100417091 hasConceptScore W3100417091C2781197716 @default.
- W3100417091 hasConceptScore W3100417091C50382708 @default.
- W3100417091 hasConceptScore W3100417091C55493867 @default.
- W3100417091 hasConceptScore W3100417091C71924100 @default.
- W3100417091 hasConceptScore W3100417091C72563966 @default.
- W3100417091 hasLocation W31004170911 @default.
- W3100417091 hasOpenAccess W3100417091 @default.
- W3100417091 hasPrimaryLocation W31004170911 @default.
- W3100417091 hasRelatedWork W12982117 @default.
- W3100417091 hasRelatedWork W14127037 @default.
- W3100417091 hasRelatedWork W17257946 @default.
- W3100417091 hasRelatedWork W17844780 @default.
- W3100417091 hasRelatedWork W18255528 @default.
- W3100417091 hasRelatedWork W20365122 @default.
- W3100417091 hasRelatedWork W20874565 @default.
- W3100417091 hasRelatedWork W2953784 @default.
- W3100417091 hasRelatedWork W7720014 @default.
- W3100417091 hasRelatedWork W9424455 @default.
- W3100417091 isParatext "false" @default.
- W3100417091 isRetracted "false" @default.
- W3100417091 magId "3100417091" @default.
- W3100417091 workType "article" @default.