Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100433141> ?p ?o ?g. }
- W3100433141 endingPage "476" @default.
- W3100433141 startingPage "464" @default.
- W3100433141 abstract "The single nucleotide polymorphism rs7804356 located in the Src kinase-associated phosphoprotein 2 (SKAP2) gene is associated with type 1 diabetes (T1D), suggesting SKAP2 as a causal candidate gene. The objective of the study was to investigate if SKAP2 has a functional role in the β-cells in relation to T1D. In a cohort of children with newly diagnosed T1D, rs7804356 predicted glycemic control and residual β-cell function during the 1st year after diagnosis. In INS-1E cells and rat and human islets, proinflammatory cytokines reduced the content of SKAP2. Functional studies revealed that knockdown of SKAP2 aggravated cytokine-induced apoptosis in INS-1E cells and primary rat β-cells, suggesting an antiapoptotic function of SKAP2. In support of this, overexpression of SKAP2 afforded protection against cytokine-induced apoptosis, which correlated with reduced nuclear content of S536-phosphorylated nuclear factor-κB (NF-κB) subunit p65, lower nitric oxide production, and diminished CHOP expression indicative of decreased endoplasmic reticulum stress. Knockdown of CHOP partially counteracted the increase in cytokine-induced apoptosis caused by SKAP2 knockdown. In conclusion, our results suggest that SKAP2 controls β-cell sensitivity to cytokines possibly by affecting the NF-κB–inducible nitric oxide synthase–endoplasmic reticulum stress pathway." @default.
- W3100433141 created "2020-11-23" @default.
- W3100433141 creator A5001781082 @default.
- W3100433141 creator A5005408832 @default.
- W3100433141 creator A5010645983 @default.
- W3100433141 creator A5015877599 @default.
- W3100433141 creator A5028557045 @default.
- W3100433141 creator A5028920939 @default.
- W3100433141 creator A5031070879 @default.
- W3100433141 creator A5037117098 @default.
- W3100433141 creator A5060488381 @default.
- W3100433141 creator A5077009996 @default.
- W3100433141 date "2020-11-17" @default.
- W3100433141 modified "2023-10-14" @default.
- W3100433141 title "<i>SKAP2</i>, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients" @default.
- W3100433141 cites W1518815928 @default.
- W3100433141 cites W1593385535 @default.
- W3100433141 cites W1891992783 @default.
- W3100433141 cites W1980059212 @default.
- W3100433141 cites W1988160514 @default.
- W3100433141 cites W1990410261 @default.
- W3100433141 cites W1995411333 @default.
- W3100433141 cites W2021830513 @default.
- W3100433141 cites W2024108088 @default.
- W3100433141 cites W2024853260 @default.
- W3100433141 cites W2025511820 @default.
- W3100433141 cites W2030234563 @default.
- W3100433141 cites W2032714982 @default.
- W3100433141 cites W2035253975 @default.
- W3100433141 cites W2043625554 @default.
- W3100433141 cites W2048018172 @default.
- W3100433141 cites W2059436317 @default.
- W3100433141 cites W2070665653 @default.
- W3100433141 cites W2070942920 @default.
- W3100433141 cites W2072738635 @default.
- W3100433141 cites W2077955816 @default.
- W3100433141 cites W2078296265 @default.
- W3100433141 cites W2087759407 @default.
- W3100433141 cites W2089560759 @default.
- W3100433141 cites W2089934054 @default.
- W3100433141 cites W2093090129 @default.
- W3100433141 cites W2100305481 @default.
- W3100433141 cites W2102909249 @default.
- W3100433141 cites W2107478456 @default.
- W3100433141 cites W2108234281 @default.
- W3100433141 cites W2112371420 @default.
- W3100433141 cites W2125871871 @default.
- W3100433141 cites W2133964808 @default.
- W3100433141 cites W2139279363 @default.
- W3100433141 cites W2146237406 @default.
- W3100433141 cites W2148270304 @default.
- W3100433141 cites W2154388604 @default.
- W3100433141 cites W2162000478 @default.
- W3100433141 cites W2174690782 @default.
- W3100433141 cites W2186803051 @default.
- W3100433141 cites W2191404924 @default.
- W3100433141 cites W2206697283 @default.
- W3100433141 cites W2287906200 @default.
- W3100433141 cites W2291768935 @default.
- W3100433141 cites W2414859413 @default.
- W3100433141 cites W2489743034 @default.
- W3100433141 cites W2588471422 @default.
- W3100433141 cites W2604286228 @default.
- W3100433141 doi "https://doi.org/10.2337/db20-0092" @default.
- W3100433141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7881866" @default.
- W3100433141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33203694" @default.
- W3100433141 hasPublicationYear "2020" @default.
- W3100433141 type Work @default.
- W3100433141 sameAs 3100433141 @default.
- W3100433141 citedByCount "7" @default.
- W3100433141 countsByYear W31004331412022 @default.
- W3100433141 countsByYear W31004331412023 @default.
- W3100433141 crossrefType "journal-article" @default.
- W3100433141 hasAuthorship W3100433141A5001781082 @default.
- W3100433141 hasAuthorship W3100433141A5005408832 @default.
- W3100433141 hasAuthorship W3100433141A5010645983 @default.
- W3100433141 hasAuthorship W3100433141A5015877599 @default.
- W3100433141 hasAuthorship W3100433141A5028557045 @default.
- W3100433141 hasAuthorship W3100433141A5028920939 @default.
- W3100433141 hasAuthorship W3100433141A5031070879 @default.
- W3100433141 hasAuthorship W3100433141A5037117098 @default.
- W3100433141 hasAuthorship W3100433141A5060488381 @default.
- W3100433141 hasAuthorship W3100433141A5077009996 @default.
- W3100433141 hasBestOaLocation W31004331411 @default.
- W3100433141 hasConcept C126322002 @default.
- W3100433141 hasConcept C134018914 @default.
- W3100433141 hasConcept C139447449 @default.
- W3100433141 hasConcept C153911025 @default.
- W3100433141 hasConcept C158617107 @default.
- W3100433141 hasConcept C164027704 @default.
- W3100433141 hasConcept C173396325 @default.
- W3100433141 hasConcept C190283241 @default.
- W3100433141 hasConcept C203014093 @default.
- W3100433141 hasConcept C2776914184 @default.
- W3100433141 hasConcept C2777622882 @default.
- W3100433141 hasConcept C2778690821 @default.
- W3100433141 hasConcept C2779725641 @default.
- W3100433141 hasConcept C502942594 @default.