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- W3100438405 abstract "Preexisting diabetes (PD) and post-transplant diabetes mellitus (PTDM) are common and severe comorbidities posttransplantation. The immunosuppressive regimens are modifiable risk factors.We reviewed Pubmed and Cochrane database and we summarize the mechanisms and impacts of available immunosuppressive treatments on the risk of PD and PTDM. We also assess the possible management of these drugs to improve glycemic parameters while considering risks inherent in transplantation.PD i) increases the risk of sepsis, ii) is an independent risk factor for infection-related mortality, and iii) increases acute rejection risk. Regarding PTDM development i) immunosuppressive strategies without corticosteroids significantly reduce the risk but the price may be a higher incidence of rejection; ii) minimization or rapid withdrawal of steroids are two valuable approaches; iii) the diabetogenic role of calcineurin inhibitors(CNIs) is also well-described and is more important for tacrolimus than for cyclosporine. Reducing tacrolimus-exposure may improve glycemic parameters but also has a higher risk of rejection. PTDM risk is higher in patients that receive sirolimus compared to mycophenolate mofetil. Finally, conversion from CNIs to belatacept may offer the best benefits to PTDM-recipients in terms of glycemic parameters, graft and patient-outcomes." @default.
- W3100438405 created "2020-11-23" @default.
- W3100438405 creator A5009177361 @default.
- W3100438405 creator A5033304061 @default.
- W3100438405 creator A5066608092 @default.
- W3100438405 creator A5077289325 @default.
- W3100438405 creator A5086033107 @default.
- W3100438405 date "2020-12-15" @default.
- W3100438405 modified "2023-10-13" @default.
- W3100438405 title "pre-existing diabetes and PTDM in kidney transplant recipients: how to handle immunosuppression" @default.
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