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- W3100448104 abstract "Astaxanthin is a natural lipid-soluble and red-orange carotenoid. Due to its strong antioxidant property, anti-inflammatory, anti-apoptotic, and immune modulation, astaxanthin has gained growing interest as a multi-target pharmacological agent against various diseases. In the current review, the anti-inflammation mechanisms of astaxanthin involved in targeting for inflammatory biomarkers and multiple signaling pathways, including PI3K/AKT, Nrf2, NF-κB, ERK1/2, JNK, p38 MAPK, and JAK-2/STAT-3, have been described. Furthermore, the applications of anti-inflammatory effects of astaxanthin in neurological diseases, diabetes, gastrointestinal diseases, hepatic and renal diseases, eye and skin disorders, are highlighted. In addition to the protective effects of astaxanthin in various chronic and acute diseases, we also summarize recent advances for the inconsistent roles of astaxanthin in infectious diseases, and give our view that the exact function of astaxanthin in response to different pathogen infection and the potential protective effects of astaxanthin in viral infectious diseases should be important research directions in the future." @default.
- W3100448104 created "2020-11-23" @default.
- W3100448104 creator A5026684908 @default.
- W3100448104 creator A5045887396 @default.
- W3100448104 date "2020-11-16" @default.
- W3100448104 modified "2023-10-06" @default.
- W3100448104 title "Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions" @default.
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- W3100448104 doi "https://doi.org/10.3390/molecules25225342" @default.
- W3100448104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7696511" @default.
- W3100448104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33207669" @default.
- W3100448104 hasPublicationYear "2020" @default.
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