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- W3100464437 abstract "APLN, APELA and their common receptor APLNR (composing the apelinergic axis) have been described in various species with extensive body distribution and multiple physiological functions. Recent studies have witnessed emerging intracellular cascades triggered by APLN and APELA which play crucial roles in female reproductive organs, including hypothalamus-pituitary-gonadal axis, ovary, oviduct, uterus and placenta. However, a comprehensive summary of APLN and APELA roles in physiology and pathology of female reproductive system has not been reported to date. In this review, we aim to concentrate on the general characteristics of APLN and APELA, as well as their specific physiological roles in female reproductive system. Meanwhile, the pathological contexts of apelinergic axis dysregulation in the obstetrics and gynecology are also summarized here, suggesting its potential prospect as a diagnostic biomarker and/or therapeutic intervention in the polycystic ovary syndrome, ovarian cancer, preeclampsia and gestational diabetes mellitus." @default.
- W3100464437 created "2020-11-23" @default.
- W3100464437 creator A5027249460 @default.
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- W3100464437 creator A5085116395 @default.
- W3100464437 date "2020-11-11" @default.
- W3100464437 modified "2023-10-03" @default.
- W3100464437 title "Emerging roles of APLN and APELA in the physiology and pathology of the female reproductive system" @default.
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