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• W3100475892 abstract "Abstract Lumpy skin disease virus (LSDV), a poxvirus that causes severe disease in cattle, has in the last few years rapidly extended its distribution from Africa and the Middle East into Europe, Russia, and across Asia. LSDV is believed to be primarily spread mechanically by blood-feeding arthropods, however the exact mode of arthropod transmission, the relative ability of different arthropod species to acquire and retain the virus, as well as their comparative importance for LSDV transmission, remain poorly characterised. Since the vector-borne nature of LSDV transmission is believed to have enabled the rapid geographic expansion of this virus, the lack of quantitative evidence on LSDV transmission has impeded effective control of the disease during the current epidemic. Obtaining high quality data on virus transmission by arthropods is challenging, and practical limitations often result in inadequate arthropod numbers or model hosts, limiting the transferability of experimental findings to the natural transmission scenario. We have addressed these limitations in this study. Using a highly representative bovine experimental model of lumpy skin disease we allowed four representative vector species ( Aedes aegypti, Culex quinquefasciatus, Stomoxys calcitrans and Culicoides nubeculosus ) to blood-feed on LSDV-inoculated cattle in order to examine the acquisition and retention of LSDV by these species in unprecedented detail. We found the probability of LSDV transmission from clinical cattle to vector correlated with disease severity. Subclinical disease was more common than clinical disease in the inoculated cattle, however the probability of vectors acquiring LSDV from subclinical animals was very low. All four potential vector species studied had a similar rate of acquisition of LSDV after feeding on the host, but Aedes aegypti and Stomoxys calcitrans retained the virus for a longer time, up to 8 days. There was no evidence of virus replication in the vector, consistent with mechanical rather than biological transmission. The parameters obtained in the in-vivo transmission experiments subsequently enabled enhanced modelling approaches to determine the basic reproduction number of LSDV in cattle mediated by each of the insect species. This was highest for Stomoxys calcitrans (19.1), C. nubeculosus (7.4), and Ae. aegypti (2.4), surprisingly indicating these three species are all potentially efficient transmitters of LSDV. These results reveal that currently applied LSDV control measures such as stamping out of all cattle on affected premises or insect control measures targeting single species need to be urgently reconsidered. Overall our studies have highlighted that the combination of highly relevant in-vivo experiments and mathematical modelling can be directly applied to devise evidence-based proportionate and targeted control programmes." @default.
• W3100475892 created "2020-11-23" @default.
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• W3100475892 date "2020-06-18" @default.
• W3100475892 modified "2023-09-26" @default.
• W3100475892 title "Quantifying and modelling the acquisition and retention of lumpy skin disease virus by haematophagus insects reveals clinically but not subclinically-affected cattle are promoters of viral transmission and key targets for control of disease outbreaks" @default.
• W3100475892 cites W1572499934 @default.
• W3100475892 cites W1957362763 @default.
• W3100475892 cites W1963600159 @default.
• W3100475892 cites W1963606948 @default.
• W3100475892 cites W1967462477 @default.
• W3100475892 cites W1974815428 @default.
• W3100475892 cites W1979864969 @default.
• W3100475892 cites W1980135548 @default.
• W3100475892 cites W1983876149 @default.
• W3100475892 cites W1992681962 @default.
• W3100475892 cites W1995780830 @default.
• W3100475892 cites W2000644613 @default.
• W3100475892 cites W2002620870 @default.
• W3100475892 cites W2011850230 @default.
• W3100475892 cites W2025236698 @default.
• W3100475892 cites W2034457575 @default.
• W3100475892 cites W2040025489 @default.
• W3100475892 cites W2044235106 @default.
• W3100475892 cites W2054130625 @default.
• W3100475892 cites W2057765075 @default.
• W3100475892 cites W2070377868 @default.
• W3100475892 cites W2113180976 @default.
• W3100475892 cites W2116975638 @default.
• W3100475892 cites W2121734930 @default.
• W3100475892 cites W2125454666 @default.
• W3100475892 cites W2129067001 @default.
• W3100475892 cites W2135973421 @default.
• W3100475892 cites W2140763962 @default.
• W3100475892 cites W2142725244 @default.
• W3100475892 cites W2144562734 @default.
• W3100475892 cites W2145555670 @default.
• W3100475892 cites W2147603964 @default.
• W3100475892 cites W2155742240 @default.
• W3100475892 cites W2157761374 @default.
• W3100475892 cites W2159819449 @default.
• W3100475892 cites W2164152339 @default.
• W3100475892 cites W2167315865 @default.
• W3100475892 cites W2170303106 @default.
• W3100475892 cites W2170930106 @default.
• W3100475892 cites W2176721523 @default.
• W3100475892 cites W2186869784 @default.
• W3100475892 cites W2278838769 @default.
• W3100475892 cites W2298073534 @default.
• W3100475892 cites W2320689954 @default.
• W3100475892 cites W2324604861 @default.
• W3100475892 cites W2330595200 @default.
• W3100475892 cites W2406587373 @default.
• W3100475892 cites W2519323818 @default.
• W3100475892 cites W2540095572 @default.
• W3100475892 cites W2561484000 @default.
• W3100475892 cites W2590220745 @default.
• W3100475892 cites W2600272795 @default.
• W3100475892 cites W268614176 @default.
• W3100475892 cites W2738111791 @default.
• W3100475892 cites W2752222182 @default.
• W3100475892 cites W2781716635 @default.
• W3100475892 cites W2801833826 @default.
• W3100475892 cites W2807198971 @default.
• W3100475892 cites W2829746041 @default.
• W3100475892 cites W2924058747 @default.
• W3100475892 cites W2947588729 @default.
• W3100475892 cites W2947651356 @default.
• W3100475892 cites W2950005378 @default.
• W3100475892 cites W2974575067 @default.
• W3100475892 cites W2994919490 @default.
• W3100475892 cites W2997973168 @default.
• W3100475892 cites W3000669330 @default.
• W3100475892 cites W3011204238 @default.
• W3100475892 cites W3012625630 @default.
• W3100475892 cites W3016297756 @default.
• W3100475892 cites W4211181162 @default.
• W3100475892 cites W4238834309 @default.
• W3100475892 cites W4302331569 @default.
• W3100475892 doi "https://doi.org/10.1101/2020.06.18.154252" @default.
• W3100475892 hasPublicationYear "2020" @default.
• W3100475892 type Work @default.

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