FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100482718> ?p ?o ?g. }

• W3100482718 abstract "SUMMARY Ionizing radiation stimulates nuclear accumulation of Abl tyrosine kinase that is required for directly irradiated cells to produce microRNA-34c-containing extracellular vesicles, which transfer the microRNA into non-irradiated cells to induce reactive oxygen species and bystander DNA damage. ABSTRACT Ionizing radiation (IR) activates an array of DNA damage response (DDR) that includes the induction of bystander effects (BE) in cells not targeted by radiation. How DDR pathways in irradiated cells stimulate BE in non-targeted cells is mostly unknown. We show here that extracellular vesicles from irradiated cells (EV-IR) induce reactive oxygen species (ROS) and DNA damage when internalized by un-irradiated cells. We found that EV-IR from Abl-NLS-mutated cells could not induce ROS or DNA damage, and restoration of nuclear Abl rescued those defects. Expanding a previous finding that Abl stimulates miR-34c expression, we show here that nuclear Abl also drives the vesicular secretion of miR-34c. Ectopic miR-34c expression, without irradiation, generated EV-miR-34c capable of inducing ROS and DNA damage. Furthermore, EV-IR from miR34-knockout cells could not induce ROS and raised γH2AX to lesser extent than EV-IR from miR34-wild type cells. These results establish a novel role for the Abl-miR-34c DDR pathway in stimulating radiation-induced bystander effects." @default.
• W3100482718 created "2020-11-23" @default.
• W3100482718 creator A5014479978 @default.
• W3100482718 creator A5070219936 @default.
• W3100482718 creator A5078367819 @default.
• W3100482718 creator A5088616406 @default.
• W3100482718 date "2017-10-26" @default.
• W3100482718 modified "2023-09-28" @default.
• W3100482718 title "Nuclear Abl Drives miR-34c Transfer by Extracellular Vesicles to Induce Radiation Bystander Effects" @default.
• W3100482718 cites W1551573586 @default.
• W3100482718 cites W1842148282 @default.
• W3100482718 cites W1877686344 @default.
• W3100482718 cites W1957311725 @default.
• W3100482718 cites W1965559955 @default.
• W3100482718 cites W1972710550 @default.
• W3100482718 cites W1973085375 @default.
• W3100482718 cites W1990903058 @default.
• W3100482718 cites W2009105537 @default.
• W3100482718 cites W2011465438 @default.
• W3100482718 cites W2014433188 @default.
• W3100482718 cites W2030075101 @default.
• W3100482718 cites W2031805423 @default.
• W3100482718 cites W2038540701 @default.
• W3100482718 cites W2039862710 @default.
• W3100482718 cites W2041816353 @default.
• W3100482718 cites W2045041347 @default.
• W3100482718 cites W2046758915 @default.
• W3100482718 cites W2051663161 @default.
• W3100482718 cites W2055313665 @default.
• W3100482718 cites W2063878022 @default.
• W3100482718 cites W2069201630 @default.
• W3100482718 cites W2071550135 @default.
• W3100482718 cites W2088930918 @default.
• W3100482718 cites W2094558289 @default.
• W3100482718 cites W2097942385 @default.
• W3100482718 cites W2120600243 @default.
• W3100482718 cites W2126787895 @default.
• W3100482718 cites W2132900511 @default.
• W3100482718 cites W2133900563 @default.
• W3100482718 cites W2144154026 @default.
• W3100482718 cites W2144958510 @default.
• W3100482718 cites W2150973377 @default.
• W3100482718 cites W2275333326 @default.
• W3100482718 cites W2283707038 @default.
• W3100482718 cites W2296538017 @default.
• W3100482718 cites W2327541311 @default.
• W3100482718 cites W2344300142 @default.
• W3100482718 cites W2614491298 @default.
• W3100482718 doi "https://doi.org/10.1101/209767" @default.
• W3100482718 hasPublicationYear "2017" @default.
• W3100482718 type Work @default.
• W3100482718 sameAs 3100482718 @default.
• W3100482718 citedByCount "0" @default.
• W3100482718 crossrefType "posted-content" @default.
• W3100482718 hasAuthorship W3100482718A5014479978 @default.
• W3100482718 hasAuthorship W3100482718A5070219936 @default.
• W3100482718 hasAuthorship W3100482718A5078367819 @default.
• W3100482718 hasAuthorship W3100482718A5088616406 @default.
• W3100482718 hasBestOaLocation W31004827181 @default.
• W3100482718 hasConcept C104317684 @default.
• W3100482718 hasConcept C143425029 @default.
• W3100482718 hasConcept C145059251 @default.
• W3100482718 hasConcept C153911025 @default.
• W3100482718 hasConcept C185592680 @default.
• W3100482718 hasConcept C19106626 @default.
• W3100482718 hasConcept C203014093 @default.
• W3100482718 hasConcept C20518536 @default.
• W3100482718 hasConcept C2908689518 @default.
• W3100482718 hasConcept C48349386 @default.
• W3100482718 hasConcept C54355233 @default.
• W3100482718 hasConcept C552990157 @default.
• W3100482718 hasConcept C55493867 @default.
• W3100482718 hasConcept C81885089 @default.
• W3100482718 hasConcept C86803240 @default.
• W3100482718 hasConcept C95444343 @default.
• W3100482718 hasConcept C97037327 @default.
• W3100482718 hasConceptScore W3100482718C104317684 @default.
• W3100482718 hasConceptScore W3100482718C143425029 @default.
• W3100482718 hasConceptScore W3100482718C145059251 @default.
• W3100482718 hasConceptScore W3100482718C153911025 @default.
• W3100482718 hasConceptScore W3100482718C185592680 @default.
• W3100482718 hasConceptScore W3100482718C19106626 @default.
• W3100482718 hasConceptScore W3100482718C203014093 @default.
• W3100482718 hasConceptScore W3100482718C20518536 @default.
• W3100482718 hasConceptScore W3100482718C2908689518 @default.
• W3100482718 hasConceptScore W3100482718C48349386 @default.
• W3100482718 hasConceptScore W3100482718C54355233 @default.
• W3100482718 hasConceptScore W3100482718C552990157 @default.
• W3100482718 hasConceptScore W3100482718C55493867 @default.
• W3100482718 hasConceptScore W3100482718C81885089 @default.
• W3100482718 hasConceptScore W3100482718C86803240 @default.
• W3100482718 hasConceptScore W3100482718C95444343 @default.
• W3100482718 hasConceptScore W3100482718C97037327 @default.
• W3100482718 hasLocation W31004827181 @default.
• W3100482718 hasLocation W31004827182 @default.
• W3100482718 hasOpenAccess W3100482718 @default.
• W3100482718 hasPrimaryLocation W31004827181 @default.
• W3100482718 hasRelatedWork W1248955089 @default.
• W3100482718 hasRelatedWork W1522324183 @default.
• W3100482718 hasRelatedWork W1818044769 @default.

• next