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• W3100488449 abstract "Perfluoroalkyl chemicals (PFCs) are widely detected in the environment and human body, and they have been linked to asthma and a number of respiratory responses in children and mice. However, no previous studies have investigated the association between exposure to PFCs and airway inflammation in adults. To evaluate the associations between serum PFCs and fractional exhaled nitric oxide (FeNO), a biomarker of airway inflammation, in adults. A cross-sectional study of 3630 adults aged 20–79 years who participated in the National Health and Nutrition Examination Survey (NHANES, 2007–2012) was conducted. Serum concentrations of five major PFCs were measured using SPE-HPLC-TIS-MS/MS method, including perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorodecanoic acid (PFDE). The detection rates of them were all >85%. Weighted multivariable linear regression and Bayesian kernel machine regression (BKMR) analyses were applied to examine the associations between serum PFCs and FeNO. After adjusted for potential confounding factors, linear regression analyses found that compared with their lowest tertiles, highest tertiles of PFOS, PFDE and PFOA were significantly associated with 5.02% (95% CI: 1.40%, 8.77%), 3.77% (95% CI: 0.30%, 7.36%) and 6.34% (95% CI: 2.81%, 10.01%) increases in FeNO, respectively. The second tertile of PFNA was significantly correlated with a 4.79% (95% CI: 1.41%, 8.29%) increase in FeNO compared with the lowest tertile. In the BKMR analysis, the mixture effect of PFCs on FeNO increased significantly when the PFC levels were at or above the 60th percentiles compared to those at their medians. PFOS and PFOA displayed significant positive single-exposure effects on FeNO when all the other PFCs are set at a particular threshold. This study provided preliminary evidence that serum PFCs were positively associated with increased FeNO in adults." @default.
• W3100488449 created "2020-11-23" @default.
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• W3100488449 date "2021-07-01" @default.
• W3100488449 modified "2023-10-02" @default.
• W3100488449 title "Association between exposure to polyfluoroalkyl chemicals and increased fractional exhaled nitric oxide in adults" @default.
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• W3100488449 doi "https://doi.org/10.1016/j.envres.2020.110450" @default.
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• W3100488449 hasPublicationYear "2021" @default.
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