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- W3100491381 abstract "Abstract The recent extension of human lifespan has not been matched by equivalent improvements in late-life health due to the global pandemic in type-2 diabetes, obesity and cardiovascular disease, ageing-associated conditions exacerbated by widespread adoption of the high calorie Western diet (HCD). As a novel therapeutic strategy, we have investigated the potential of ES-62, an immunomodulator secreted by the parasitic worm Acanthocheilonema viteae , to improve healthspan by targeting the chronic inflammation that drives metabolic dysregulation underpinning ageing-induced ill-health. We found that ES-62 improves a range of inflammatory but also pathophysiological, metabolic and microbiome parameters, when administered subcutaneously at only 1 µg/week throughout the lifespan of HCD-fed mice. Strikingly, ES-62 induced sex-specific healthspan signatures and indeed, it substantially increased the median survival of male, but not female, HCD-mice. Modelling of 113 responses contributing to these differential signatures by machine learning approaches now signposts candidate parameters key to promoting both healthspan and lifespan." @default.
- W3100491381 created "2020-11-23" @default.
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- W3100491381 date "2019-04-30" @default.
- W3100491381 modified "2023-09-27" @default.
- W3100491381 title "Parasitic worm-derived ES-62 promotes health- and life-span in high calorie diet-fed mice" @default.
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- W3100491381 doi "https://doi.org/10.1101/622753" @default.
- W3100491381 hasPublicationYear "2019" @default.
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