FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100494655> ?p ?o ?g. }

• W3100494655 endingPage "145" @default.
• W3100494655 startingPage "132" @default.
• W3100494655 abstract "Keloid disorder, a group of fibroproliferative skin diseases, is characterized by unremitting accumulation of the extracellular matrix (ECM) of connective tissue, primarily collagen, to develop cutaneous tumors on the predilection sites of skin. There is a strong genetic predisposition for keloid formation, and individuals of African and Asian ancestry are particularly prone. The principal cell type responsible for ECM accumulation is the myofibroblast derived from quiescent resident skin fibroblasts either through trans-differentiation or from keloid progenitor stem cells with capacity for multi-lineage differentiation and self-renewal. The biosynthetic pathways leading to ECM accumulation are activated by several cytokines, but particularly by TGF-β signalling. The mechanical properties of the cellular microenvironment also play a critical role in the cell's response to TGF-β, as demonstrated by culturing of fibroblasts derived from keloids and control skin on substrata with different degrees of stiffness. These studies also demonstrated that culturing of fibroblasts on tissue culture plastic in vitro does not reflect their biosynthetic capacity in vivo. Collectively, our current understanding of the pathogenesis of keloids suggests a complex network of interacting cellular, molecular and mechanical factors, with distinct pathways leading to myofibroblast differentiation and activation. Keloids can serve as a model system of fibrotic diseases, a group of currently intractable disorders, and deciphering of the critical pathogenetic steps leading to ECM accumulation is expected to identify targets for pharmacologic intervention, not only for keloids but also for a number of other, both genetic and acquired, fibrotic diseases." @default.
• W3100494655 created "2020-11-23" @default.
• W3100494655 creator A5032533037 @default.
• W3100494655 creator A5036646549 @default.
• W3100494655 creator A5064610064 @default.
• W3100494655 creator A5088529813 @default.
• W3100494655 date "2020-12-20" @default.
• W3100494655 modified "2023-09-24" @default.
• W3100494655 title "Keloid disorder: Fibroblast differentiation and gene expression profile in fibrotic skin diseases" @default.
• W3100494655 cites W1491436476 @default.
• W3100494655 cites W1561185557 @default.
• W3100494655 cites W1588127651 @default.
• W3100494655 cites W1892883644 @default.
• W3100494655 cites W1895277992 @default.
• W3100494655 cites W1906450972 @default.
• W3100494655 cites W1950808465 @default.
• W3100494655 cites W1964195356 @default.
• W3100494655 cites W1965588383 @default.
• W3100494655 cites W1969183806 @default.
• W3100494655 cites W1969565221 @default.
• W3100494655 cites W1975142493 @default.
• W3100494655 cites W1977437151 @default.
• W3100494655 cites W1977815598 @default.
• W3100494655 cites W1980193533 @default.
• W3100494655 cites W1980325398 @default.
• W3100494655 cites W1985760249 @default.
• W3100494655 cites W1986297742 @default.
• W3100494655 cites W1989412685 @default.
• W3100494655 cites W1990574061 @default.
• W3100494655 cites W1991095357 @default.
• W3100494655 cites W1994553956 @default.
• W3100494655 cites W1996708329 @default.
• W3100494655 cites W1997064567 @default.
• W3100494655 cites W1997832474 @default.
• W3100494655 cites W2003331504 @default.
• W3100494655 cites W2008204899 @default.
• W3100494655 cites W2011093418 @default.
• W3100494655 cites W2012452602 @default.
• W3100494655 cites W2013026724 @default.
• W3100494655 cites W2018128871 @default.
• W3100494655 cites W2018544300 @default.
• W3100494655 cites W2021113111 @default.
• W3100494655 cites W2028548574 @default.
• W3100494655 cites W2028828450 @default.
• W3100494655 cites W2032013289 @default.
• W3100494655 cites W2035653659 @default.
• W3100494655 cites W2037618281 @default.
• W3100494655 cites W2040992047 @default.
• W3100494655 cites W2042606264 @default.
• W3100494655 cites W2043898918 @default.
• W3100494655 cites W2044008951 @default.
• W3100494655 cites W2048035811 @default.
• W3100494655 cites W2048055673 @default.
• W3100494655 cites W2048339727 @default.
• W3100494655 cites W2050742799 @default.
• W3100494655 cites W2052147002 @default.
• W3100494655 cites W2052806727 @default.
• W3100494655 cites W2064682352 @default.
• W3100494655 cites W2066188919 @default.
• W3100494655 cites W2066422411 @default.
• W3100494655 cites W2067399742 @default.
• W3100494655 cites W2068508458 @default.
• W3100494655 cites W2069995585 @default.
• W3100494655 cites W2072369387 @default.
• W3100494655 cites W2076896780 @default.
• W3100494655 cites W2079907174 @default.
• W3100494655 cites W2086706655 @default.
• W3100494655 cites W2093136003 @default.
• W3100494655 cites W2095718854 @default.
• W3100494655 cites W2110586785 @default.
• W3100494655 cites W2110658593 @default.
• W3100494655 cites W2112365941 @default.
• W3100494655 cites W2112541119 @default.
• W3100494655 cites W2115785626 @default.
• W3100494655 cites W2116043657 @default.
• W3100494655 cites W2122808924 @default.
• W3100494655 cites W2125874167 @default.
• W3100494655 cites W2131432937 @default.
• W3100494655 cites W2131845382 @default.
• W3100494655 cites W2133860937 @default.
• W3100494655 cites W2134164289 @default.
• W3100494655 cites W2136445803 @default.
• W3100494655 cites W2138577363 @default.
• W3100494655 cites W2138871107 @default.
• W3100494655 cites W2141310245 @default.
• W3100494655 cites W2141768942 @default.
• W3100494655 cites W2144449878 @default.
• W3100494655 cites W2145568812 @default.
• W3100494655 cites W2145570488 @default.
• W3100494655 cites W2146337514 @default.
• W3100494655 cites W2147209470 @default.
• W3100494655 cites W2147673404 @default.
• W3100494655 cites W2151878020 @default.
• W3100494655 cites W2153763131 @default.
• W3100494655 cites W2159731793 @default.
• W3100494655 cites W2163036793 @default.
• W3100494655 cites W2165653104 @default.
• W3100494655 cites W2166224134 @default.

• next